SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ic6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 ALA A 292
PHE A 311
ARG A 211
ASN A 169
 None
 1.19A 1t9wA-4ic6A:
undetectable		 1t9wA-4ic6A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 290
GLY A 157
GLY A 294
ILE A 166
VAL A 131
 None
 0.96A 2oxtA-4ic6A:
undetectable		 2oxtA-4ic6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 296
GLY A 294
VAL A 158
ILE A 281
ALA A 323
 None
 0.99A 2yy8A-4ic6A:
undetectable
2yy8B-4ic6A:
undetectable		 2yy8A-4ic6A:
21.05
2yy8B-4ic6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASN A 132
VAL A 131
GLY A 293
ILE A 287
ASN A 288
 None
 1.30A 3bwmA-4ic6A:
undetectable		 3bwmA-4ic6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 381
ARG A 432
GLU A 378
LEU A 439
ILE A 430
 None
 1.17A 3kvrA-4ic6A:
undetectable		 3kvrA-4ic6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 381
ARG A 432
GLU A 378
LEU A 439
ILE A 430
 None
 1.09A 3kvrB-4ic6A:
undetectable		 3kvrB-4ic6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 GLY A 381
ARG A 432
GLU A 378
LEU A 439
ILE A 430
 None
 1.18A 3nbqA-4ic6A:
undetectable		 3nbqA-4ic6A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ILE A 262
ILE A 304
VAL A 232
LEU A 303
VAL A 158
 None
 1.16A 3w67A-4ic6A:
undetectable		 3w67A-4ic6A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 293
ASN A 169
ILE A 230
SER A 129
ASN A 291
 None
 1.04A 4pooA-4ic6A:
undetectable		 4pooA-4ic6A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 SER A 327
GLY A 280
ASN A 266
ILE A 304
 None
 1.04A 5j4nA-4ic6A:
undetectable		 5j4nA-4ic6A:
24.11