SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ich'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 4ich TRANSCRIPTIONAL
REGULATOR
(Saccharomonospor
a
viridis) 		3 / 3 ALA A 147
VAL A 152
TRP A 194
 None
None
B3P  A 302 (-4.2A)
 0.86A 1nt5A-4ichA:
undetectable		 1nt5A-4ichA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 4ich TRANSCRIPTIONAL
REGULATOR
(Saccharomonospor
a
viridis) 		3 / 3 ALA A 147
VAL A 152
TRP A 194
 None
None
B3P  A 302 (-4.2A)
 0.86A 1nt5B-4ichA:
undetectable		 1nt5B-4ichA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4ich TRANSCRIPTIONAL
REGULATOR
(Saccharomonospor
a
viridis) 		5 / 11 VAL A 258
LEU A 259
GLY A 255
ILE A 251
THR A 183
 BME  A 301 (-4.6A)
None
None
B3P  A 302 ( 4.9A)
None
 1.31A 3bjwH-4ichA:
undetectable		 3bjwH-4ichA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4ich TRANSCRIPTIONAL
REGULATOR
(Saccharomonospor
a
viridis) 		4 / 7 VAL A 177
ILE A 278
ILE A 282
THR A 225
 None
 0.87A 3deuA-4ichA:
3.0		 3deuA-4ichA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ich TRANSCRIPTIONAL
REGULATOR
(Saccharomonospor
a
viridis) 		5 / 12 ILE A 119
LEU A 126
ARG A 107
LEU A 108
THR A 132
 None
None
EDO  A 304 (-3.6A)
EDO  A 304 (-4.7A)
None
 1.15A 5e8qB-4ichA:
undetectable		 5e8qB-4ichA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ich TRANSCRIPTIONAL
REGULATOR
(Saccharomonospor
a
viridis) 		5 / 12 ILE A 119
LEU A 126
ARG A 107
LEU A 108
THR A 132
 None
None
EDO  A 304 (-3.6A)
EDO  A 304 (-4.7A)
None
 1.10A 5ujxB-4ichA:
undetectable		 5ujxB-4ichA:
19.49