SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ici'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4ici PUTATIVE
FLAVOPROTEIN
(Bacteroides
eggerthii) 		5 / 10 LEU A 164
VAL A 139
ASP A 163
ALA A 121
ASN A 126
 None
 1.41A 1fpqA-4iciA:
undetectable		 1fpqA-4iciA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4ici PUTATIVE
FLAVOPROTEIN
(Bacteroides
eggerthii) 		4 / 4 GLY A 151
ASP A 119
GLY A 146
THR A  46
 None
None
FMN  A 200 (-3.3A)
FMN  A 200 (-3.6A)
 0.82A 1hxbB-4iciA:
undetectable		 1hxbB-4iciA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4ici PUTATIVE
FLAVOPROTEIN
(Bacteroides
eggerthii) 		4 / 7 ILE A 129
LYS A 100
ILE A  64
TYR A 114
 None
 1.17A 3eteD-4iciA:
2.1
3eteF-4iciA:
2.1		 3eteD-4iciA:
17.68
3eteF-4iciA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4ici PUTATIVE
FLAVOPROTEIN
(Bacteroides
eggerthii) 		4 / 4 GLY A 151
ASP A 119
GLY A 146
THR A  46
 None
None
FMN  A 200 (-3.3A)
FMN  A 200 (-3.6A)
 0.77A 3k4vC-4iciA:
undetectable		 3k4vC-4iciA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 4ici PUTATIVE
FLAVOPROTEIN
(Bacteroides
eggerthii) 		5 / 11 ALA A  49
VAL A  37
GLY A  54
ALA A  55
LEU A 172
 None
 1.00A 3sm2B-4iciA:
undetectable		 3sm2B-4iciA:
20.45