SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4icq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		3 / 3 ALA A  42
HIS A  43
VAL A  46
 None
 0.45A 1lqtB-4icqA:
undetectable		 1lqtB-4icqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		3 / 3 ALA A  42
HIS A  43
VAL A  46
 None
 0.47A 1lquB-4icqA:
undetectable		 1lquB-4icqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 LEU A 349
GLU A 319
ILE A 386
TYR A 215
 None
ZN  A 502 ( 2.5A)
None
None
 1.10A 1qvtA-4icqA:
undetectable		 1qvtA-4icqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 LEU A 226
THR A 223
CYH A 320
TYR A 215
 None
 1.38A 1uw6P-4icqA:
undetectable
1uw6T-4icqA:
undetectable		 1uw6P-4icqA:
18.25
1uw6T-4icqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 12 PHE A 341
TRP A 154
LEU A  17
ALA A  14
ILE A  45
 None
 1.21A 2bxpA-4icqA:
undetectable		 2bxpA-4icqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 TYR A 266
SER A 346
LEU A 213
THR A 335
 None
 0.95A 2v0zO-4icqA:
undetectable		 2v0zO-4icqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 12 GLY A 318
LEU A 222
VAL A 267
SER A 269
ASP A 383
 None
None
None
None
ZN  A 501 (-2.2A)
 1.42A 2vqyA-4icqA:
undetectable		 2vqyA-4icqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 6 ILE A  87
MET A 133
PRO A 132
VAL A  46
 None
 1.12A 2ygoA-4icqA:
undetectable		 2ygoA-4icqA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 8 GLU A 319
HIS A 348
ASP A 383
HIS A 381
GLU A 343
 ZN  A 502 ( 2.5A)
ZN  A 502 (-3.5A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.4A)
ZN  A 502 ( 4.2A)
 1.21A 3a6jA-4icqA:
undetectable		 3a6jA-4icqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 7 GLU A 319
HIS A 348
ASP A 383
HIS A 381
GLU A 343
 ZN  A 502 ( 2.5A)
ZN  A 502 (-3.5A)
ZN  A 501 (-2.2A)
ZN  A 501 (-3.4A)
ZN  A 502 ( 4.2A)
 1.21A 3a6jB-4icqA:
undetectable		 3a6jB-4icqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 12 ILE A 292
SER A 269
LEU A 273
VAL A 382
MET A 304
 None
 1.24A 3adsB-4icqA:
undetectable		 3adsB-4icqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		3 / 3 ASP A  64
ASN A  67
SER A 105
 None
 0.94A 3lslA-4icqA:
undetectable
3lslD-4icqA:
undetectable		 3lslA-4icqA:
20.50
3lslD-4icqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		3 / 3 SER A 105
ASP A  64
ASN A  67
 None
 0.95A 3lslA-4icqA:
undetectable
3lslD-4icqA:
undetectable		 3lslA-4icqA:
20.50
3lslD-4icqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 ZN  A 501 (-2.2A)
ZN  A 502 ( 2.5A)
None
ZN  A 502 (-3.5A)
ZN  A 501 (-4.8A)
 1.47A 3o94A-4icqA:
undetectable		 3o94A-4icqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 ZN  A 501 (-2.2A)
ZN  A 502 ( 2.5A)
None
ZN  A 502 (-3.5A)
ZN  A 501 (-4.8A)
 1.47A 3o94B-4icqA:
undetectable		 3o94B-4icqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 ZN  A 501 (-2.2A)
ZN  A 502 ( 2.5A)
None
ZN  A 502 (-3.5A)
ZN  A 501 (-4.8A)
 1.46A 3o94C-4icqA:
undetectable		 3o94C-4icqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 11 ASP A 383
GLU A 319
PHE A 255
HIS A 348
TYR A 355
 ZN  A 501 (-2.2A)
ZN  A 502 ( 2.5A)
None
ZN  A 502 (-3.5A)
ZN  A 501 (-4.8A)
 1.47A 3o94D-4icqA:
undetectable		 3o94D-4icqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 ZN  A 502 ( 4.2A)
ZN  A 502 ( 2.5A)
ZN  A 501 (-4.8A)
None
 1.11A 3rqwC-4icqA:
undetectable
3rqwD-4icqA:
undetectable		 3rqwC-4icqA:
21.14
3rqwD-4icqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 ZN  A 502 ( 4.2A)
ZN  A 502 ( 2.5A)
ZN  A 501 (-4.8A)
None
 1.13A 3rqwF-4icqA:
undetectable
3rqwJ-4icqA:
undetectable		 3rqwF-4icqA:
21.14
3rqwJ-4icqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 5 LEU A 222
GLY A 265
ILE A 292
VAL A 293
 None
 0.92A 3wriB-4icqA:
undetectable		 3wriB-4icqA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 7 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 ZN  A 502 ( 4.2A)
ZN  A 502 ( 2.5A)
ZN  A 501 (-4.8A)
None
 1.06A 4a97H-4icqA:
undetectable		 4a97H-4icqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		3 / 3 LYS A 156
LEU A 152
ALA A 168
 None
 0.72A 4ikiA-4icqA:
undetectable		 4ikiA-4icqA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 12 ASN A  67
GLY A 109
ILE A 280
GLY A 300
ASN A 276
 None
 1.23A 4obwC-4icqA:
2.9		 4obwC-4icqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 7 ALA A 202
GLY A 236
ALA A 235
THR A 251
 None
 0.85A 4r1zB-4icqA:
undetectable		 4r1zB-4icqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 5 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 ZN  A 502 ( 4.2A)
ZN  A 502 ( 2.5A)
ZN  A 501 (-4.8A)
None
 1.12A 4twdA-4icqA:
undetectable
4twdE-4icqA:
undetectable		 4twdA-4icqA:
22.25
4twdE-4icqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 7 GLU A 343
GLU A 319
TYR A 355
PHE A 255
 ZN  A 502 ( 4.2A)
ZN  A 502 ( 2.5A)
ZN  A 501 (-4.8A)
None
 1.16A 4twdF-4icqA:
undetectable
4twdJ-4icqA:
undetectable		 4twdF-4icqA:
22.25
4twdJ-4icqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		3 / 3 VAL A 238
LEU A 370
MET A 365
 None
 0.90A 5ikrA-4icqA:
undetectable		 5ikrA-4icqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 THR A 223
CYH A 320
TYR A 215
LEU A 226
 None
 1.15A 5kxiD-4icqA:
undetectable
5kxiE-4icqA:
undetectable		 5kxiD-4icqA:
22.49
5kxiE-4icqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 12 SER A 358
ARG A 377
SER A 378
GLY A 352
ALA A 354
 None
 1.12A 5l5zH-4icqA:
undetectable
5l5zN-4icqA:
undetectable		 5l5zH-4icqA:
19.81
5l5zN-4icqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		5 / 12 ALA A  42
GLU A  48
LEU A  17
ILE A  22
VAL A  57
 None
 1.04A 5vlmB-4icqA:
undetectable		 5vlmB-4icqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 8 THR A 223
CYH A 320
TYR A 215
LEU A 226
 None
 1.32A 6cnjD-4icqA:
undetectable
6cnjE-4icqA:
undetectable		 6cnjD-4icqA:
14.76
6cnjE-4icqA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 5 ILE A 283
SER A 269
ALA A 350
LEU A 307
 None
None
ZN  A 501 ( 4.3A)
None
 1.04A 6dwnA-4icqA:
undetectable		 6dwnA-4icqA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4icq AMINOPEPTIDASE PEPS
(Streptococcus
pneumoniae) 		4 / 7 GLY A 300
LYS A 299
ASN A 112
GLY A 277
 None
 0.92A 6n7fA-4icqA:
undetectable		 6n7fA-4icqA:
12.96