SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4id9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 11 LEU A 237
LEU A 238
ALA A 239
LEU A 157
LEU A  62
 None
 1.16A 1g50A-4id9A:
undetectable		 1g50A-4id9A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 156
LEU A 157
TYR A 110
SER A 106
GLU A 140
 None
None
None
NAD  A 403 (-3.6A)
None
 1.24A 2a58A-4id9A:
2.2
2a58B-4id9A:
2.3		 2a58A-4id9A:
20.13
2a58B-4id9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 156
LEU A 157
TYR A 110
SER A 106
GLU A 140
 None
None
None
NAD  A 403 (-3.6A)
None
 1.23A 2a58B-4id9A:
2.3
2a58C-4id9A:
3.2		 2a58B-4id9A:
20.13
2a58C-4id9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 156
LEU A 157
TYR A 110
SER A 106
GLU A 140
 None
None
None
NAD  A 403 (-3.6A)
None
 1.24A 2a58D-4id9A:
3.4
2a58E-4id9A:
3.0		 2a58D-4id9A:
20.13
2a58E-4id9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 VAL A  15
ILE A   2
VAL A  58
ILE A  55
LEU A  64
 None
None
None
None
NAD  A 403 (-4.6A)
 1.27A 4a84A-4id9A:
undetectable		 4a84A-4id9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 VAL A  98
ARG A  99
MET A 152
GLU A 153
 None
 0.84A 4hojA-4id9A:
undetectable		 4hojA-4id9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 THR A  86
HIS A  63
THR A 135
ALA A  66
LEU A  45
 None
None
None
NAD  A 403 (-3.3A)
NAD  A 403 (-3.7A)
 1.38A 4pbhA-4id9A:
undetectable		 4pbhA-4id9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 7 PRO A  33
GLU A  40
ASP A 170
THR A 166
 None
 1.28A 4uacA-4id9A:
undetectable		 4uacA-4id9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 MET A 152
VAL A  61
ALA A  54
ALA A  92
ASP A  91
 None
 0.81A 4v01B-4id9A:
undetectable		 4v01B-4id9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 GLY A   6
ASP A  30
LEU A  31
SER A  44
VAL A  81
 NAD  A 403 ( 3.8A)
NAD  A 403 (-2.8A)
NAD  A 403 (-3.9A)
NAD  A 403 (-3.1A)
NAD  A 403 (-4.0A)
 0.65A 5dpdB-4id9A:
4.8		 5dpdB-4id9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 104
THR A 289
PHE A 159
GLY A 107
TYR A 110
 NAD  A 403 ( 3.8A)
None
NAD  A 403 (-3.9A)
None
None
 1.15A 5hfjC-4id9A:
undetectable		 5hfjC-4id9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 104
THR A 289
PHE A 159
GLY A 107
TYR A 110
 NAD  A 403 ( 3.8A)
None
NAD  A 403 (-3.9A)
None
None
 1.16A 5hfjF-4id9A:
undetectable		 5hfjF-4id9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 104
THR A 289
PHE A 159
GLY A 107
TYR A 110
 NAD  A 403 ( 3.8A)
None
NAD  A 403 (-3.9A)
None
None
 1.17A 5hfjG-4id9A:
undetectable		 5hfjG-4id9A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.86A 5hm8A-4id9A:
7.1		 5hm8A-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.87A 5hm8B-4id9A:
7.2		 5hm8B-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.87A 5hm8C-4id9A:
7.2		 5hm8C-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.87A 5hm8D-4id9A:
7.1		 5hm8D-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.87A 5hm8E-4id9A:
6.7		 5hm8E-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.87A 5hm8F-4id9A:
6.7		 5hm8F-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.87A 5hm8H-4id9A:
undetectable		 5hm8H-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 252
MET A 232
VAL A 233
GLY A 235
LEU A 240
 None
 1.08A 5iktA-4id9A:
undetectable		 5iktA-4id9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		4 / 5 THR A 289
GLU A 122
THR A 249
LEU A 126
 None
 0.83A 5utuH-4id9A:
7.5		 5utuH-4id9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 247
ALA A 246
SER A  94
HIS A  63
GLU A 140
 None
 1.25A 5wbvA-4id9A:
undetectable		 5wbvA-4id9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 10 VAL A 155
GLY A 248
ALA A 239
LEU A 157
ASN A 251
 None
 1.09A 5x6yB-4id9A:
2.6		 5x6yB-4id9A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 THR A 289
VAL A 120
LEU A 126
ARG A 158
SER A 106
 None
None
None
None
NAD  A 403 (-3.6A)
 1.27A 6ak3A-4id9A:
undetectable		 6ak3A-4id9A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Agrobacterium
fabrum) 		5 / 12 HIS A 146
SER A  94
HIS A  63
LEU A 142
LEU A  89
 None
 1.34A 6chgC-4id9A:
undetectable		 6chgC-4id9A:
17.02