SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4idm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 406
ASN A 364
ILE A 359
ASP A 361
 None
 1.13A 1yc2D-4idmA:
4.0		 1yc2D-4idmA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 406
ASN A 364
ILE A 359
ASP A 361
 None
 0.97A 1yc2E-4idmA:
2.4		 1yc2E-4idmA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 230
TRP A 118
LEU A 114
ALA A 231
 None
 1.19A 2jstA-4idmA:
undetectable
2jstB-4idmA:
undetectable		 2jstA-4idmA:
7.87
2jstB-4idmA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 183
PRO A 178
THR A 520
TRP A 519
 None
 1.45A 2q6oB-4idmA:
2.1		 2q6oB-4idmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 320
LEU A 412
LEU A 348
ALA A 351
 None
 0.99A 2vcvB-4idmA:
undetectable		 2vcvB-4idmA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 320
LEU A 412
LEU A 348
ALA A 351
 None
 1.02A 2vcvG-4idmA:
undetectable		 2vcvG-4idmA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 355
ASP A 361
ILE A 359
GLN A  62
 None
 1.41A 2ya7C-4idmA:
undetectable		 2ya7C-4idmA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 215
PHE A 246
PRO A 213
PHE A 263
 None
 1.10A 2ygnA-4idmA:
undetectable		 2ygnA-4idmA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 240
GLY A 196
PRO A 199
ILE A 146
LEU A 227
 None
 1.18A 2zzmA-4idmA:
4.3		 2zzmA-4idmA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 147
ILE A 139
TYR A 135
VAL A  15
ASN A  12
 None
 1.46A 3a8iA-4idmA:
undetectable		 3a8iA-4idmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 147
ILE A 139
TYR A 135
VAL A  15
ASN A  12
 None
 1.46A 3a8iB-4idmA:
undetectable		 3a8iB-4idmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 147
ILE A 139
TYR A 135
VAL A  15
ASN A  12
 None
 1.46A 3a8iD-4idmA:
undetectable		 3a8iD-4idmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 140
THR A 126
ILE A 122
LEU A 114
THR A 224
 None
 1.29A 3bexC-4idmA:
2.4
3bexD-4idmA:
2.3		 3bexC-4idmA:
18.02
3bexD-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 114
THR A 224
ASP A 140
THR A 126
ILE A 122
 None
 1.28A 3bexC-4idmA:
undetectable
3bexD-4idmA:
2.3		 3bexC-4idmA:
18.02
3bexD-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 140
THR A 126
ILE A 122
LEU A 114
THR A 224
 None
 1.28A 3bexE-4idmA:
undetectable
3bexF-4idmA:
2.4		 3bexE-4idmA:
18.02
3bexF-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 114
THR A 224
ASP A 140
THR A 126
ILE A 122
 None
 1.29A 3bexE-4idmA:
undetectable
3bexF-4idmA:
2.4		 3bexE-4idmA:
18.02
3bexF-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 140
THR A 126
ILE A 122
LEU A 114
THR A 224
 None
 1.27A 3bf1A-4idmA:
2.4
3bf1B-4idmA:
2.3		 3bf1A-4idmA:
18.02
3bf1B-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 140
THR A 126
ILE A 122
LEU A 114
THR A 224
 None
 1.27A 3bf1C-4idmA:
2.3
3bf1D-4idmA:
2.3		 3bf1C-4idmA:
18.02
3bf1D-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 114
THR A 224
ASP A 140
THR A 126
ILE A 122
 None
 1.27A 3bf1C-4idmA:
2.3
3bf1D-4idmA:
2.3		 3bf1C-4idmA:
18.02
3bf1D-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 140
THR A 126
ILE A 122
LEU A 114
THR A 224
 None
 1.28A 3bf1E-4idmA:
2.4
3bf1F-4idmA:
undetectable		 3bf1E-4idmA:
18.02
3bf1F-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 114
THR A 224
ASP A 140
THR A 126
ILE A 122
 None
 1.24A 3bf1E-4idmA:
2.4
3bf1F-4idmA:
undetectable		 3bf1E-4idmA:
18.02
3bf1F-4idmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 427
GLY A 324
ALA A 329
LEU A 430
 None
 0.96A 3bgdA-4idmA:
3.0		 3bgdA-4idmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 215
SER A 214
PRO A 213
PRO A 188
 None
 1.40A 3bjwC-4idmA:
undetectable		 3bjwC-4idmA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  84
VAL A 248
ILE A 238
PRO A 213
THR A 242
 None
 1.14A 3el5A-4idmA:
undetectable		 3el5A-4idmA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 442
ASP A 446
ASP A 473
 None
 0.68A 3jb2A-4idmA:
3.4		 3jb2A-4idmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  84
VAL A 248
ILE A 238
PRO A 213
THR A 242
 None
 1.11A 3spkA-4idmA:
undetectable		 3spkA-4idmA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 283
GLY A 181
PHE A 182
SER A 286
 None
 0.91A 3tzfB-4idmA:
undetectable		 3tzfB-4idmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 471
THR A 470
LEU A 445
GLY A 458
ALA A 478
 None
 1.13A 4ypmA-4idmA:
2.8		 4ypmA-4idmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 206
LEU A 228
ILE A 122
THR A 187
THR A 208
 None
 1.13A 4ze2A-4idmA:
undetectable		 4ze2A-4idmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 201
THR A 200
VAL A 209
HIS A 262
 None
 1.11A 5ecnA-4idmA:
undetectable		 5ecnA-4idmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 206
LEU A 228
ILE A 122
THR A 187
THR A 208
 None
 1.09A 5eskA-4idmA:
undetectable		 5eskA-4idmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 519
THR A 200
VAL A 209
HIS A 262
 None
 0.94A 5ewuB-4idmA:
1.8		 5ewuB-4idmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 262
ALA A 201
VAL A 183
GLY A 181
ALA A 259
 None
 1.08A 5jw1B-4idmA:
0.5		 5jw1B-4idmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 198
PHE A 191
GLU A 144
THR A 457
GLY A 480
 None
 1.20A 5xiqA-4idmA:
2.0		 5xiqA-4idmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 198
PHE A 191
GLU A 144
THR A 457
GLY A 480
 None
 1.20A 5xiqD-4idmA:
2.7		 5xiqD-4idmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 429
VAL A 407
GLY A 387
VAL A 393
 None
 1.07A 6ak3B-4idmA:
undetectable		 6ak3B-4idmA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 466
GLU A 442
HIS A 303
ALA A 467
 None
 1.44A 6f6jC-4idmA:
undetectable
6f6jD-4idmA:
undetectable		 6f6jC-4idmA:
22.36
6f6jD-4idmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 121
LEU A  35
ALA A 123
LEU A 128
 None
 1.50A 6gnrA-4idmA:
undetectable		 6gnrA-4idmA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 121
LEU A  35
ALA A 123
LEU A 128
 None
 1.49A 6gnrB-4idmA:
undetectable		 6gnrB-4idmA:
14.29