SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ied'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
 0.61A 1ghmA-4iedA:
18.2		 1ghmA-4iedA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		5 / 11 GLY A 213
ARG A 244
GLU A 240
PHE A 211
GLU A 186
 None
 1.16A 2fl5A-4iedA:
undetectable
2fl5B-4iedA:
0.5
2fl5F-4iedA:
0.6		 2fl5A-4iedA:
22.26
2fl5B-4iedA:
21.46
2fl5F-4iedA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		3 / 3 ASP A  96
TYR A  81
LYS A 113
 EDO  A 305 (-3.2A)
None
None
 1.18A 2othA-4iedA:
undetectable		 2othA-4iedA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
None
 1.07A 3ny4A-4iedA:
19.0		 3ny4A-4iedA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		4 / 8 PHE A  80
ILE A 182
TYR A 111
LEU A 114
 None
None
KCX  A  60 ( 3.8A)
None
 0.79A 3rqwI-4iedA:
undetectable
3rqwJ-4iedA:
undetectable		 3rqwI-4iedA:
22.45
3rqwJ-4iedA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.63A 3sh8A-4iedA:
19.8		 3sh8A-4iedA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
 0.62A 3sh8B-4iedA:
19.9		 3sh8B-4iedA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		5 / 10 SER A 106
LYS A 196
THR A 197
GLY A 198
ARG A 239
 KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.88A 4fh2A-4iedA:
18.6		 4fh2A-4iedA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.63A 4n9kA-4iedA:
19.8		 4n9kA-4iedA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.62A 4n9kB-4iedA:
19.7		 4n9kB-4iedA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 209
PHE A  31
GLY A  29
ILE A  21
TYR A 246
 None
 1.25A 4rtsA-4iedA:
undetectable		 4rtsA-4iedA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		3 / 3 ASN A  75
PHE A  80
TYR A 111
 None
None
KCX  A  60 ( 3.8A)
 0.85A 4u15A-4iedA:
undetectable		 4u15A-4iedA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
 0.61A 5ghyA-4iedA:
19.9		 5ghyA-4iedA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 ALA A  56
SER A  57
SER A 106
LYS A 196
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
 0.60A 5ghyB-4iedA:
19.9		 5ghyB-4iedA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 11 ALA A  56
SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.61A 5ghzA-4iedA:
19.8		 5ghzA-4iedA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 10 ALA A  56
SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ARG A 239
 None
KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.63A 5ghzB-4iedA:
19.8		 5ghzB-4iedA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		5 / 10 VAL A 108
LEU A  90
PHE A  89
GLY A 198
ALA A  56
 KCX  A  60 ( 3.9A)
CL  A 303 ( 4.1A)
None
None
None
 1.19A 5mxbA-4iedA:
1.9		 5mxbA-4iedA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		4 / 6 LYS A  19
ARG A  24
GLU A  23
LYS A  25
 None
 1.23A 6an0A-4iedA:
undetectable		 6an0A-4iedA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
None
 1.10A 6b5yB-4iedA:
19.1		 6b5yB-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.97A 6b5yD-4iedA:
19.2		 6b5yD-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.87A 6b68B-4iedA:
19.0		 6b68B-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
 1.12A 6b68D-4iedA:
19.2		 6b68D-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
None
 0.83A 6b69A-4iedA:
19.2
6b69B-4iedA:
19.2		 6b69A-4iedA:
15.51
6b69B-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
 0.72A 6b69D-4iedA:
18.9		 6b69D-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
None
 1.05A 6b6aB-4iedA:
19.0		 6b6aB-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		7 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
ASP A 202
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
None
 1.01A 6b6aD-4iedA:
19.0		 6b6aD-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
 0.79A 6b6cA-4iedA:
19.2		 6b6cA-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		6 / 12 SER A  57
SER A 106
ARG A 239
LYS A 196
THR A 197
GLY A 198
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
None
KCX  A  60 ( 4.5A)
None
None
 0.80A 6b6eA-4iedA:
19.3		 6b6eA-4iedA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6F_A_9F2A301_1
(BETA-LACTAMASE)		 4ied CLASS D
BETA-LACTAMASE
(Fusobacterium
nucleatum) 		5 / 12 SER A  57
SER A 106
LYS A 196
THR A 197
GLY A 198
 KCX  A  60 ( 2.7A)
KCX  A  60 ( 3.4A)
KCX  A  60 ( 4.5A)
None
None
 0.48A 6b6fA-4iedA:
19.1		 6b6fA-4iedA:
15.51