SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ieg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		3 / 3 ALA A 262
VAL A 141
TRP A 139
 None
 0.95A 1c4dC-4iegA:
undetectable
1c4dD-4iegA:
undetectable		 1c4dC-4iegA:
2.48
1c4dD-4iegA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		5 / 8 ASN A 466
TRP A 329
GLY A 468
TRP A 432
VAL A 438
 None
 1.23A 1dbbH-4iegA:
undetectable
1dbbL-4iegA:
undetectable		 1dbbH-4iegA:
16.23
1dbbL-4iegA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 ASN A 246
ASN A 544
ASN A 200
THR A 192
 None
 1.24A 1h7xA-4iegA:
undetectable		 1h7xA-4iegA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 ASN A 246
ASN A 544
ASN A 200
THR A 192
 None
 1.23A 1h7xB-4iegA:
undetectable		 1h7xB-4iegA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 ASN A 246
ASN A 544
ASN A 200
THR A 192
 None
 1.24A 1h7xC-4iegA:
undetectable		 1h7xC-4iegA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 ASN A 246
ASN A 544
ASN A 200
THR A 192
 None
 1.24A 1h7xD-4iegA:
undetectable		 1h7xD-4iegA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		5 / 11 LEU A  52
GLU A 238
ALA A 224
GLY A 220
ARG A  21
 None
 1.33A 1l5rA-4iegA:
undetectable		 1l5rA-4iegA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 TRP A 549
GLY A 590
PHE A 588
SER A 587
 None
 1.18A 2a3cA-4iegA:
undetectable		 2a3cA-4iegA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 TRP A 549
GLY A 590
PHE A 588
SER A 587
 None
 1.20A 2a3cB-4iegA:
undetectable		 2a3cB-4iegA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		5 / 11 TYR A 353
VAL A 434
ILE A 435
ILE A 362
PHE A 498
 None
 1.32A 2dg3A-4iegA:
undetectable		 2dg3A-4iegA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 PRO A 537
LEU A  84
ARG A 533
GLY A 552
 None
 1.24A 2hs2B-4iegA:
undetectable		 2hs2B-4iegA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 LYS A 186
ASN A 319
GLY A 316
PRO A 312
 None
 1.06A 2ys6A-4iegA:
undetectable		 2ys6A-4iegA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 7 PHE A 646
MET A 649
PHE A 650
ILE A 185
 None
 1.19A 2zseA-4iegA:
undetectable		 2zseA-4iegA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 LEU A 380
SER A 383
ALA A 239
ALA A 240
 None
 0.86A 3ax9B-4iegA:
undetectable		 3ax9B-4iegA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 VAL A 167
VAL A 166
GLN A 158
ARG A 170
 None
 1.20A 3bjwF-4iegA:
undetectable		 3bjwF-4iegA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 SER A 383
LEU A 410
TYR A 409
PHE A 233
 None
 0.93A 3i45A-4iegA:
undetectable		 3i45A-4iegA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 PHE A  97
GLY A  86
PHE A 531
PHE A 101
 None
 1.06A 3ko0B-4iegA:
undetectable
3ko0J-4iegA:
undetectable		 3ko0B-4iegA:
9.77
3ko0J-4iegA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		5 / 10 PHE A 650
PHE A 313
ALA A 314
ILE A 185
PHE A 646
 None
 1.30A 3t3qA-4iegA:
undetectable		 3t3qA-4iegA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		3 / 3 PRO A 502
ASP A 349
GLU A 504
 None
 0.88A 3v4tC-4iegA:
undetectable		 3v4tC-4iegA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 PHE A 291
SER A  89
ARG A  99
VAL A  94
 None
 1.33A 4d32A-4iegA:
undetectable
4d32B-4iegA:
undetectable		 4d32A-4iegA:
20.71
4d32B-4iegA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 PHE A 291
SER A  89
ARG A  99
VAL A  94
 None
 1.38A 4v3yA-4iegA:
undetectable
4v3yB-4iegA:
undetectable		 4v3yA-4iegA:
20.71
4v3yB-4iegA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 6 LEU A 380
ILE A 377
LEU A 222
TYR A 221
 None
 0.96A 4w5nA-4iegA:
1.3		 4w5nA-4iegA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 4 GLY A 510
LEU A 340
PHE A 339
ILE A 465
 None
 0.93A 4xv2A-4iegA:
1.5		 4xv2A-4iegA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 5 LEU A 212
TYR A 208
ALA A 239
ILE A 306
 None
 1.18A 4y03B-4iegA:
undetectable		 4y03B-4iegA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 8 ASN A 307
PHE A 385
HIS A 622
THR A 245
 None
 1.44A 5hqaA-4iegA:
undetectable		 5hqaA-4iegA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		5 / 8 TYR A 353
VAL A 434
ILE A 435
ILE A 362
PHE A 498
 None
 1.23A 5hw8H-4iegA:
undetectable		 5hw8H-4iegA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		3 / 3 HIS A  38
HIS A  37
HIS A  29
 None
 0.59A 5oexA-4iegA:
undetectable		 5oexA-4iegA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 7 ARG A 556
GLU A 525
TRP A 608
ARG A 623
 None
 1.14A 5umwB-4iegA:
undetectable
5umwE-4iegA:
undetectable		 5umwB-4iegA:
8.56
5umwE-4iegA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 7 ALA A 224
GLY A 220
TYR A 221
TYR A 218
 None
 1.01A 5uxdA-4iegA:
undetectable		 5uxdA-4iegA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 5 PHE A 347
ASP A 469
GLU A 503
ASN A 253
 None
None
MG  A1001 (-2.3A)
None
 1.48A 5ybbA-4iegA:
0.4		 5ybbA-4iegA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		5 / 12 ILE A 130
LEU A 554
PHE A 588
PHE A 573
LEU A 589
 None
 1.39A 6a93A-4iegA:
undetectable		 6a93A-4iegA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		3 / 3 ARG A 526
ARG A 623
ARG A 533
 None
 1.06A 6bplA-4iegA:
undetectable
6bplB-4iegA:
undetectable		 6bplA-4iegA:
8.86
6bplB-4iegA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4ieg RNA-DEPENDENT RNA
POLYMERASE P2
(Pseudomonas
phage
phi12) 		4 / 5 SER A 351
VAL A 350
LYS A 499
PRO A 502
 None
 1.18A 6fi4A-4iegA:
undetectable
6fi4B-4iegA:
undetectable		 6fi4A-4iegA:
15.49
6fi4B-4iegA:
0.76