SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 PHE A 152
TYR A 188
LEU A 192
THR A 159
 None
 1.13A 1rmtB-4ielA:
undetectable		 1rmtB-4ielA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 PHE A 152
TYR A 188
LEU A 192
THR A 159
 None
 1.07A 1rmtD-4ielA:
undetectable		 1rmtD-4ielA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 LYS A  15
ASP A  94
ASN A  67
 GSH  A 301 ( 4.3A)
None
None
 1.07A 2bm9A-4ielA:
undetectable		 2bm9A-4ielA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 6 LEU A  52
PRO A  54
GLU A  65
SER A  66
 GSH  A 301 (-3.9A)
GSH  A 301 (-4.5A)
GSH  A 301 (-3.1A)
GSH  A 301 (-2.6A)
 0.46A 3vlnA-4ielA:
20.1		 3vlnA-4ielA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 5 ALA A 202
ILE A 189
LEU A 192
ASN A 170
 None
 0.95A 4g19A-4ielA:
13.2		 4g19A-4ielA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 5 ASP A  98
TRP A  96
VAL A  93
ALA A 161
 None
 1.46A 5dl9A-4ielA:
undetectable		 5dl9A-4ielA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4iel GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 TRP A 108
GLY A 134
GLN A 130
PHE A 177
 None
 0.98A 6eqpA-4ielA:
undetectable		 6eqpA-4ielA:
15.86