SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4if2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 6 HIS A  22
HIS A  24
HIS A 178
HIS A 207
ASP A 264
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 (-2.4A)
 0.85A 1fweC-4if2A:
13.7		 1fweC-4if2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 144
VAL A  93
ILE A 139
GLY A 138
GLY A 133
 KCX  A 145 ( 4.1A)
None
None
None
None
 0.84A 1k6cA-4if2A:
undetectable		 1k6cA-4if2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 264
HIS A 207
HIS A  22
 ZN  A 401 (-2.4A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.4A)
 0.67A 1oe1A-4if2A:
undetectable		 1oe1A-4if2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 264
HIS A 207
HIS A  22
 ZN  A 401 (-2.4A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.4A)
 0.67A 1oe3A-4if2A:
undetectable		 1oe3A-4if2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  20
LEU A  57
ARG A  53
LEU A  54
ALA A 265
 None
 1.28A 2bxeA-4if2A:
undetectable		 2bxeA-4if2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 206
GLY A 186
ASP A  67
LEU A  73
TYR A 216
 None
 0.97A 2hmyB-4if2A:
undetectable		 2hmyB-4if2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 264
HIS A 207
HIS A  22
 ZN  A 401 (-2.4A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.4A)
 0.69A 2xxgA-4if2A:
undetectable		 2xxgA-4if2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 264
HIS A 207
HIS A  22
 ZN  A 401 (-2.4A)
ZN  A 402 (-3.4A)
ZN  A 401 (-3.4A)
 0.70A 2xxgC-4if2A:
undetectable		 2xxgC-4if2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 237
VAL A 234
ARG A 243
 None
 0.76A 3p73A-4if2A:
undetectable		 3p73A-4if2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 147
GLY A 156
LEU A 161
VAL A 160
 None
 1.01A 4dubA-4if2A:
undetectable		 4dubA-4if2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 HIS A  22
HIS A 178
HIS A 207
ASP A 264
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 (-2.4A)
 0.80A 4h9mA-4if2A:
5.2		 4h9mA-4if2A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  22
TRP A 284
SER A 176
 ZN  A 401 (-3.4A)
None
None
 1.16A 4lrhD-4if2A:
undetectable		 4lrhD-4if2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  96
ILE A  27
VAL A  66
ILE A 205
THR A 148
 KCX  A 145 ( 3.4A)
None
None
None
None
 1.03A 4q5mA-4if2A:
undetectable		 4q5mA-4if2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 6 HIS A  22
HIS A  24
HIS A 178
HIS A 207
ASP A 264
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.4A)
ZN  A 401 (-2.4A)
 0.68A 4ubpC-4if2A:
13.3		 4ubpC-4if2A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 THR A 179
SER A 225
LEU A 220
LEU A 227
 None
 0.89A 4wozA-4if2A:
4.1
4wozB-4if2A:
4.0		 4wozA-4if2A:
22.28
4wozB-4if2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 HIS A 285
GLY A 233
ASN A 283
HIS A 263
 None
 1.39A 5a5zC-4if2A:
undetectable		 5a5zC-4if2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  72
ASP A 264
HIS A  24
ALA A  94
TYR A 100
 None
ZN  A 401 (-2.4A)
ZN  A 401 (-3.2A)
KCX  A 145 ( 4.6A)
None
 1.22A 5igvA-4if2A:
undetectable		 5igvA-4if2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 159
ALA A 147
ASP A 149
GLY A  72
ILE A  71
 None
 0.92A 5kr1A-4if2A:
undetectable		 5kr1A-4if2A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 220
CYH A 146
LEU A 161
ASP A 188
 None
KCX  A 145 ( 4.0A)
None
None
 1.21A 5mafA-4if2A:
undetectable		 5mafA-4if2A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 312
GLY A  17
ASP A  63
ASP A  15
 None
 1.44A 6cjkC-4if2A:
undetectable		 6cjkC-4if2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 THR A 179
ASP A 264
HIS A  22
ARG A 231
 None
ZN  A 401 (-2.4A)
ZN  A 401 (-3.4A)
ZN  A 402 (-4.1A)
 1.48A 6dchA-4if2A:
undetectable		 6dchA-4if2A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Mycobacterium
tuberculosis) 		4 / 6 VAL A  66
ASN A 314
PRO A 315
ILE A 318
 None
 1.11A 6h7uA-4if2A:
undetectable		 6h7uA-4if2A:
20.68