SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ifd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		4 / 6 ILE C 299
GLU C 339
LEU C  31
LEU C 302
 None
 1.01A 1mt1B-4ifdC:
undetectable
1mt1C-4ifdC:
undetectable		 1mt1B-4ifdC:
16.25
1mt1C-4ifdC:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		4 / 8 ASN C 296
LEU C 334
ASP C 333
GLU C 339
 None
 1.21A 1mxgA-4ifdC:
undetectable		 1mxgA-4ifdC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 130
LEU C  75
ALA C 215
THR C  89
LEU C 238
 None
 1.07A 1r9oA-4ifdC:
undetectable		 1r9oA-4ifdC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 TYR C 189
ARG C  61
GLN C 278
 None
 0.89A 1tw4A-4ifdC:
undetectable		 1tw4A-4ifdC:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 GLY C  94
GLY C  93
VAL C 241
SER C 129
LEU C 284
 None
 1.14A 1ya4B-4ifdC:
undetectable		 1ya4B-4ifdC:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 291
ALA C 352
PHE C 293
ALA C 351
ILE C 394
 None
 1.15A 2aclC-4ifdC:
undetectable		 2aclC-4ifdC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 THR C 184
ASP C 249
SER C 253
 None
 0.78A 2nxeA-4ifdC:
undetectable		 2nxeA-4ifdC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 THR C 184
ASP C 249
SER C 253
 None
 0.78A 2nxeB-4ifdC:
undetectable		 2nxeB-4ifdC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 LEU C  37
ARG C  33
ILE C  39
 None
 0.63A 2xn5B-4ifdC:
undetectable		 2xn5B-4ifdC:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		4 / 4 PRO C 244
TYR C 211
GLY C  93
THR C  92
 None
 1.37A 3ib0A-4ifdC:
undetectable		 3ib0A-4ifdC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		4 / 6 ILE C 274
ILE C  91
GLY C  93
VAL C 282
 None
 0.58A 3n3iA-4ifdC:
undetectable		 3n3iA-4ifdC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 TYR C  46
SER C  36
ASP K 582
ILE K 599
 None
 1.35A 3uj7B-4ifdC:
undetectable		 3uj7B-4ifdC:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 ARG C  40
ARG K 602
ILE C 331
 None
 0.82A 4b7qA-4ifdC:
undetectable		 4b7qA-4ifdC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
EXOSOME COMPLEX
EXONUCLEASE RRP6
(Saccharomyces
cerevisiae) 		3 / 3 ARG C  40
ARG K 602
ILE C 331
 None
 0.79A 4b7qC-4ifdC:
undetectable		 4b7qC-4ifdC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 11 GLY C 364
ILE C 299
ILE C 331
LEU C 334
ILE C 343
 None
 1.01A 4dt8A-4ifdC:
undetectable		 4dt8A-4ifdC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 10 GLY C 364
ILE C 299
ILE C 331
LEU C 334
ILE C 343
 None
 0.99A 4dt8B-4ifdC:
undetectable		 4dt8B-4ifdC:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		4 / 8 ILE C 299
ILE C 331
LEU C 334
ILE C 343
 None
 0.95A 4dtaB-4ifdC:
undetectable		 4dtaB-4ifdC:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 282
LEU C 213
LEU C 170
ILE C  95
TYR C  62
 None
 1.17A 4q0dA-4ifdC:
undetectable		 4q0dA-4ifdC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 282
LEU C 213
LEU C 170
ILE C  95
TYR C  62
 None
 1.17A 4q0dB-4ifdC:
undetectable		 4q0dB-4ifdC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 VAL C 282
LEU C 213
LEU C 170
ILE C  95
TYR C  62
 None
 1.17A 4q0dE-4ifdC:
undetectable		 4q0dE-4ifdC:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 SER C 158
SER C 162
PHE C 227
 None
 0.87A 5mugA-4ifdC:
undetectable		 5mugA-4ifdC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 339
GLY C 224
GLY C 298
ARG C  44
ILE C 343
 None
 1.19A 5vooA-4ifdC:
undetectable		 5vooA-4ifdC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 339
GLY C 224
GLY C 298
ARG C  44
ILE C 343
 None
 1.16A 5vooC-4ifdC:
undetectable		 5vooC-4ifdC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 339
GLY C 224
GLY C 298
ARG C  44
ILE C 343
 None
 1.11A 5vooE-4ifdC:
undetectable		 5vooE-4ifdC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 339
GLY C 224
GLY C 298
ARG C  44
ILE C 343
 None
 1.18A 5vooF-4ifdC:
undetectable		 5vooF-4ifdC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 12 GLU C 339
GLY C 224
GLY C 298
ARG C  44
ILE C 343
 None
 1.15A 5vopB-4ifdC:
undetectable		 5vopB-4ifdC:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 THR C 223
THR C  85
ARG C  50
 None
 1.04A 5wm2A-4ifdC:
undetectable		 5wm2A-4ifdC:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		3 / 3 LYS C 358
ASN C 356
SER C 354
 None
 1.09A 5yw0A-4ifdC:
undetectable		 5yw0A-4ifdC:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 9 ARG C 391
ALA C 385
VAL C 383
SER C 381
ASP C 387
 None
 1.46A 6c2mA-4ifdC:
undetectable		 6c2mA-4ifdC:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 10 LEU C  31
SER C 342
ILE C 331
SER C 345
GLY C 298
 None
 1.35A 6dlzA-4ifdC:
undetectable
6dlzD-4ifdC:
undetectable		 6dlzA-4ifdC:
11.73
6dlzD-4ifdC:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 331
SER C 345
GLY C 298
LEU C  31
SER C 342
 None
 1.36A 6dlzB-4ifdC:
undetectable
6dlzC-4ifdC:
undetectable		 6dlzB-4ifdC:
11.73
6dlzC-4ifdC:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 10 LEU C  31
SER C 342
ILE C 331
SER C 345
GLY C 298
 None
 1.35A 6dm1A-4ifdC:
undetectable
6dm1D-4ifdC:
undetectable		 6dm1A-4ifdC:
11.73
6dm1D-4ifdC:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4ifd EXOSOME COMPLEX
COMPONENT RRP43
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 331
SER C 345
GLY C 298
LEU C  31
SER C 342
 None
 1.36A 6dm1B-4ifdC:
undetectable
6dm1C-4ifdC:
undetectable		 6dm1B-4ifdC:
11.73
6dm1C-4ifdC:
11.73