SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ife'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 ASP A 244
ASP A 251
ASP A 298
None
0.73A 1eizA-4ifeA:
4.3
1eizA-4ifeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 ASP A 244
ASP A 251
ASP A 298
None
0.73A 1ej0A-4ifeA:
3.7
1ej0A-4ifeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 SER A 241
TYR A 293
HIS A 292
None
0.55A 2r2vD-4ifeA:
undetectable
2r2vD-4ifeA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
5 / 12 VAL A 208
ASP A 212
GLN A 414
ALA A 214
ILE A 216
None
1.06A 3a35B-4ifeA:
undetectable
3a35B-4ifeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
5 / 12 VAL A 208
ASP A 212
GLN A 414
ALA A 214
ILE A 216
None
1.07A 3ddyA-4ifeA:
undetectable
3ddyA-4ifeA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 ASP A 244
ASP A 251
ASP A 298
None
0.69A 3douA-4ifeA:
4.1
3douA-4ifeA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
4 / 7 VAL A 160
TYR A 156
GLU A 206
PRO A 207
None
1.07A 3hs4A-4ifeA:
undetectable
3hs4A-4ifeA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_D_ACTD601_0
(CHOLINE OXIDASE)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
4 / 5 TRP A 143
ILE A  47
TRP A 116
VAL A  37
None
1.29A 3nneD-4ifeA:
0.0
3nneD-4ifeA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_E_ACTE601_0
(CHOLINE OXIDASE)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
4 / 4 TRP A 143
ILE A  47
TRP A 116
VAL A  37
None
1.33A 3nneE-4ifeA:
0.0
3nneE-4ifeA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 LYS A 434
SER A 211
GLN A 414
None
0.76A 3si7A-4ifeA:
4.3
3si7A-4ifeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
4 / 5 LEU A 403
ALA A 408
THR A 411
ILE A 216
None
0.94A 4xe3B-4ifeA:
undetectable
4xe3B-4ifeA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 GLU A 121
LYS A 149
ASN A 147
None
None
ATP  A 800 (-3.0A)
0.99A 4y1dA-4ifeA:
2.2
4y1dD-4ifeA:
undetectable
4y1dA-4ifeA:
15.71
4y1dD-4ifeA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
3 / 3 PHE A 139
ASP A 113
LYS A 137
None
0.80A 6awtD-4ifeA:
undetectable
6awtD-4ifeA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4ife GENE 2 PROTEIN
(Shigella
virus
Sf6)
4 / 7 ALA A 281
THR A 282
ILE A 274
TRP A 295
None
0.89A 6cduF-4ifeA:
undetectable
6cduJ-4ifeA:
undetectable
6cduF-4ifeA:
20.80
6cduJ-4ifeA:
20.80