SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ifp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A29_A_TFPA154_1 (CALMODULIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 10	GLU A 131 GLU A 132 LEU A 136 MET A 225 LEU A 116	None	1.47A	1a29A-4ifpA: undetectable	1a29A-4ifpA: 14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C4D_B_DVAB8_0 (GRAMICIDIN A)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	3 / 3	TRP A 159 VAL A 260 TRP A 341	None None MAL A 501 (-3.7A)	1.28A	1c4dA-4ifpA: undetectable 1c4dB-4ifpA: undetectable	1c4dA-4ifpA: 2.78 1c4dB-4ifpA: 2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E06_A_IPBA600_0 (ODORANT-BINDING PROTEIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 6	VAL A 9 VAL A 51 ILE A 61 ASN A 268	None	0.94A	1e06A-4ifpA: undetectable	1e06A-4ifpA: 14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HSH_A_MK1A401_2 (HIV-II PROTEASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	6 / 9	ALA A 277 ILE A 10 VAL A 36 ILE A 3 ILE A 61 ILE A 60	None	1.48A	1hshB-4ifpA: undetectable	1hshB-4ifpA: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE9_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	TYR A 342 LEU A 441 VAL A 375 VAL A 392 LEU A 401	None	1.39A	1ie9A-4ifpA: undetectable	1ie9A-4ifpA: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN0_B_T44B602_1 (TRANSTHYRETIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 7	LYS A 278 GLU A 282 ALA A 277 ALA A 78	None	1.06A	1sn0B-4ifpA: undetectable 1sn0D-4ifpA: undetectable	1sn0B-4ifpA: 15.25 1sn0D-4ifpA: 15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN5_D_T3D602_1 (TRANSTHYRETIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	LEU A 393 LEU A 396 LYS A 421 LEU A 425 VAL A 389	None	0.95A	1sn5B-4ifpA: undetectable 1sn5D-4ifpA: undetectable	1sn5B-4ifpA: 15.25 1sn5D-4ifpA: 15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN5_D_T3D602_1 (TRANSTHYRETIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	LYS A 421 LEU A 425 VAL A 389 LEU A 393 LEU A 396	None	0.94A	1sn5B-4ifpA: undetectable 1sn5D-4ifpA: undetectable	1sn5B-4ifpA: 15.25 1sn5D-4ifpA: 15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDT_A_VIAA1000_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	HIS A 445 ILE A 383 VAL A 389 LEU A 396 PHE A 423	MLI A 502 (-4.1A) None None None None	1.32A	1udtA-4ifpA: undetectable	1udtA-4ifpA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J2P_E_SC2E1289_1 (FICOLIN-2)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 6	ASP A 198 THR A 194 LYS A 201 ASP A 359	None	1.21A	2j2pE-4ifpA: undetectable 2j2pF-4ifpA: undetectable	2j2pE-4ifpA: 20.06 2j2pF-4ifpA: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VE3_A_REAA1445_1 (PUTATIVE CYTOCHROME P450 120)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	ALA A 265 LEU A 281 PHE A 280 VAL A 294 GLY A 17	None	1.10A	2ve3A-4ifpA: undetectable	2ve3A-4ifpA: 22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZW9_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 2)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 8	THR A 94 LEU A 286 ASP A 288 GLU A 112	None None None MAL A 501 (-3.0A)	1.01A	2zw9A-4ifpA: undetectable	2zw9A-4ifpA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A35_A_RBFA191_1 (LUMAZINE PROTEIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	LEU A 193 THR A 194 ALA A 347 THR A 346 ILE A 349	None	1.21A	3a35A-4ifpA: undetectable	3a35A-4ifpA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BGD_A_PM6A301_1 (THIOPURINE S-METHYLTRANSFERASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 6	PHE A 259 ALA A 163 LEU A 248 PRO A 160	None	0.95A	3bgdA-4ifpA: undetectable	3bgdA-4ifpA: 19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_C_SVRC507_1 (PHOSPHOLIPASE A2)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 7	VAL A 111 GLY A 301 PRO A 230 LYS A 306	None	0.70A	3bjwC-4ifpA: undetectable	3bjwC-4ifpA: 13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_A_EPAA1_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	VAL A 344 GLY A 188 ALA A 189 LEU A 193 LEU A 161	None	1.05A	3hs6A-4ifpA: undetectable	3hs6A-4ifpA: 21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3JYR_A_ACRA371_1 (MALTOSE-BINDING PERIPLASMIC PROTEIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	9 / 12	ASP A 15 LYS A 16 LYS A 43 GLU A 45 GLU A 46 ALA A 64 ASP A 66 ARG A 67 GLU A 112	MAL A 501 (-3.0A) MAL A 501 (-2.6A) None None None MAL A 501 (-3.3A) MAL A 501 (-2.9A) MAL A 501 (-3.8A) MAL A 501 (-3.0A)	0.73A	3jyrA-4ifpA: 61.5	3jyrA-4ifpA: 81.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3JYR_A_ACRA371_1 (MALTOSE-BINDING PERIPLASMIC PROTEIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	10 / 12	ASP A 15 LYS A 16 LYS A 43 GLU A 45 GLU A 46 ALA A 64 ASP A 66 GLU A 112 PRO A 155 TRP A 231	MAL A 501 (-3.0A) MAL A 501 (-2.6A) None None None MAL A 501 (-3.3A) MAL A 501 (-2.9A) MAL A 501 (-3.0A) MAL A 501 (-3.4A) MAL A 501 (-4.4A)	0.41A	3jyrA-4ifpA: 61.5	3jyrA-4ifpA: 81.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3JYR_A_ACRA371_2 (MALTOSE-BINDING PERIPLASMIC PROTEIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	6 / 7	ASN A 13 TRP A 63 GLU A 154 TYR A 156 MET A 331 TRP A 341	MAL A 501 ( 4.8A) MAL A 501 (-4.4A) MAL A 501 (-3.7A) MAL A 501 (-3.8A) MAL A 501 (-4.2A) MAL A 501 (-3.7A)	0.20A	3jyrA-4ifpA: 61.5	3jyrA-4ifpA: 81.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3JYR_A_ACRA371_2 (MALTOSE-BINDING PERIPLASMIC PROTEIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 7	TRP A 63 TYR A 156 MET A 331 TRP A 341 ARG A 345	MAL A 501 (-4.4A) MAL A 501 (-3.8A) MAL A 501 (-4.2A) MAL A 501 (-3.7A) None	0.68A	3jyrA-4ifpA: 61.5	3jyrA-4ifpA: 81.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_B_ROCB201_4 (HIV-1 PROTEASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 4	ARG A 345 ASP A 185 GLY A 167 THR A 158	None	1.17A	3k4vB-4ifpA: undetectable	3k4vB-4ifpA: 14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LCV_B_SAMB301_1 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	3 / 3	ARG A 415 ASP A 394 GLN A 403	None	0.85A	3lcvB-4ifpA: undetectable	3lcvB-4ifpA: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Y_B_DIFB585_1 (PROSTAGLANDIN G/H SYNTHASE 1)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	VAL A 197 LEU A 161 GLY A 188 ALA A 189 LEU A 362	None	0.98A	3n8yB-4ifpA: undetectable	3n8yB-4ifpA: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O7W_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 1)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	3 / 3	LYS A 421 ARG A 408 ASP A 208	None	1.29A	3o7wA-4ifpA: undetectable	3o7wA-4ifpA: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZV_B_ECNB411_1 (FLAVOHEMOGLOBIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 9	ILE A 162 GLN A 366 ALA A 363 LEU A 362 ALA A 163	None	1.09A	3ozvB-4ifpA: undetectable	3ozvB-4ifpA: 23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGH_A_FLPA701_1 (CYCLOOXYGENASE-2)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	VAL A 344 LEU A 161 GLY A 188 ALA A 189 LEU A 362	None	1.27A	3pghA-4ifpA: undetectable	3pghA-4ifpA: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_B_RTZB1_1 (CYTOCHROME P450 2D6)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	PHE A 157 GLY A 301 LEU A 300 GLU A 112 ALA A 232	None None None MAL A 501 (-3.0A) None	0.82A	3tbgB-4ifpA: undetectable	3tbgB-4ifpA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_D_RTZD1_1 (CYTOCHROME P450 2D6)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	PHE A 157 GLY A 301 LEU A 300 GLU A 112 ALA A 232	None None None MAL A 501 (-3.0A) None	0.80A	3tbgD-4ifpA: undetectable	3tbgD-4ifpA: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VWQ_A_ACAA601_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	ALA A 232 TYR A 18 TYR A 211 ASN A 235 GLY A 229	None	1.37A	3vwqA-4ifpA: undetectable	3vwqA-4ifpA: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VWR_A_ACAA601_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 11	ALA A 232 ASP A 297 TYR A 211 ASN A 235 GLY A 229	None	1.30A	3vwrA-4ifpA: undetectable	3vwrA-4ifpA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4N48_A_SAMA601_1 (CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-M ETHYLTRANSFERASE 1)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 5	ASN A 268 ALA A 52 GLY A 57 ASP A 15	None None None MAL A 501 (-3.0A)	0.96A	4n48A-4ifpA: undetectable	4n48A-4ifpA: 21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_B_NPSB602_1 (SERUM ALBUMIN)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 9	ALA A 265 ALA A 106 LEU A 104 LEU A 263 VAL A 262	None	1.16A	4or0B-4ifpA: undetectable	4or0B-4ifpA: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R87_J_SPMJ202_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	4 / 7	TYR A 342 GLU A 380 GLU A 46 ARG A 345	None	1.29A	4r87J-4ifpA: undetectable 4r87L-4ifpA: undetectable	4r87J-4ifpA: 16.48 4r87L-4ifpA: 16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_B_TLFB601_0 (PROSTAGLANDIN G/H SYNTHASE 2)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 12	VAL A 344 LEU A 161 GLY A 188 ALA A 189 LEU A 362	None	1.18A	5iktB-4ifpA: undetectable	5iktB-4ifpA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W4Z_A_RBFA502_1 (RIBOFLAVIN LYASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	6 / 12	ALA A 343 ALA A 339 GLY A 167 ALA A 189 PHE A 170 VAL A 182	None	1.38A	5w4zA-4ifpA: undetectable	5w4zA-4ifpA: 10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W4Z_B_RBFB502_1 (RIBOFLAVIN LYASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	6 / 12	ALA A 343 ALA A 339 GLY A 167 ALA A 189 PHE A 170 VAL A 182	None	1.40A	5w4zB-4ifpA: undetectable	5w4zB-4ifpA: 10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA603_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	3 / 3	TYR A 156 ASN A 228 LEU A 114	MAL A 501 (-3.8A) None None	0.82A	6b58A-4ifpA: undetectable	6b58A-4ifpA: 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BM5_A_SAMA1301_0 (METHIONINE SYNTHASE)	4ifp	MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 (Escherichia coli; Homo sapiens)	5 / 11	PRO A 134 GLU A 131 PRO A 255 ALA A 164 PRO A 160	None	1.38A	6bm5A-4ifpA: undetectable	6bm5A-4ifpA: 22.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A29_A_TFPA154_1","CALMODULIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"GLU A 131;GLU A 132;LEU A 136;MET A 225;LEU A 116","None","1.47A","1a29A-4ifpA:undetectable","1a29A-4ifpA:14.32"],["1C4D_B_DVAB8_0","GRAMICIDIN A","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",3,"TRP A 159;VAL A 260;TRP A 341","None;None;MAL A 501 (-3.7A)","1.28A","1c4dA-4ifpA:undetectable;1c4dB-4ifpA:undetectable","1c4dA-4ifpA:2.78;1c4dB-4ifpA:2.78"],["1E06_A_IPBA600_0","ODORANT-BINDING PROTEIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"VAL A   9;VAL A  51;ILE A  61;ASN A 268","None","0.94A","1e06A-4ifpA:undetectable","1e06A-4ifpA:14.88"],["1HSH_A_MK1A401_2","HIV-II PROTEASE;HIV-II PROTEASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",6,"ALA A 277;ILE A  10;VAL A  36;ILE A   3;ILE A  61;ILE A  60","None","1.48A","1hshB-4ifpA:undetectable","1hshB-4ifpA:12.86"],["1IE9_A_VDXA500_1","VITAMIN D3 RECEPTOR","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"TYR A 342;LEU A 441;VAL A 375;VAL A 392;LEU A 401","None","1.39A","1ie9A-4ifpA:undetectable","1ie9A-4ifpA:20.26"],["1SN0_B_T44B602_1","TRANSTHYRETIN;TRANSTHYRETIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"LYS A 278;GLU A 282;ALA A 277;ALA A  78","None","1.06A","1sn0B-4ifpA:undetectable;1sn0D-4ifpA:undetectable","1sn0B-4ifpA:15.25;1sn0D-4ifpA:15.25"],["1SN5_D_T3D602_1","TRANSTHYRETIN;TRANSTHYRETIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"LEU A 393;LEU A 396;LYS A 421;LEU A 425;VAL A 389","None","0.95A","1sn5B-4ifpA:undetectable;1sn5D-4ifpA:undetectable","1sn5B-4ifpA:15.25;1sn5D-4ifpA:15.25"],["1SN5_D_T3D602_1","TRANSTHYRETIN;TRANSTHYRETIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"LYS A 421;LEU A 425;VAL A 389;LEU A 393;LEU A 396","None","0.94A","1sn5B-4ifpA:undetectable;1sn5D-4ifpA:undetectable","1sn5B-4ifpA:15.25;1sn5D-4ifpA:15.25"],["1UDT_A_VIAA1000_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"HIS A 445;ILE A 383;VAL A 389;LEU A 396;PHE A 423","MLI A 502 (-4.1A);None;None;None;None","1.32A","1udtA-4ifpA:undetectable","1udtA-4ifpA:20.67"],["2J2P_E_SC2E1289_1","FICOLIN-2;FICOLIN-2","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"ASP A 198;THR A 194;LYS A 201;ASP A 359","None","1.21A","2j2pE-4ifpA:undetectable;2j2pF-4ifpA:undetectable","2j2pE-4ifpA:20.06;2j2pF-4ifpA:20.06"],["2VE3_A_REAA1445_1","PUTATIVE CYTOCHROME P450 120","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"ALA A 265;LEU A 281;PHE A 280;VAL A 294;GLY A  17","None","1.10A","2ve3A-4ifpA:undetectable","2ve3A-4ifpA:22.18"],["2ZW9_A_SAMA801_1","LEUCINE CARBOXYL METHYLTRANSFERASE 2","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"THR A  94;LEU A 286;ASP A 288;GLU A 112","None;None;None;MAL A 501 (-3.0A)","1.01A","2zw9A-4ifpA:undetectable","2zw9A-4ifpA:20.67"],["3A35_A_RBFA191_1","LUMAZINE PROTEIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"LEU A 193;THR A 194;ALA A 347;THR A 346;ILE A 349","None","1.21A","3a35A-4ifpA:undetectable","3a35A-4ifpA:17.89"],["3BGD_A_PM6A301_1","THIOPURINE S-METHYLTRANSFERASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"PHE A 259;ALA A 163;LEU A 248;PRO A 160","None","0.95A","3bgdA-4ifpA:undetectable","3bgdA-4ifpA:19.17"],["3BJW_C_SVRC507_1","PHOSPHOLIPASE A2","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"VAL A 111;GLY A 301;PRO A 230;LYS A 306","None","0.70A","3bjwC-4ifpA:undetectable","3bjwC-4ifpA:13.13"],["3HS6_A_EPAA1_1","PROSTAGLANDIN G\/H SYNTHASE 2","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"VAL A 344;GLY A 188;ALA A 189;LEU A 193;LEU A 161","None","1.05A","3hs6A-4ifpA:undetectable","3hs6A-4ifpA:21.05"],["3JYR_A_ACRA371_1","MALTOSE-BINDING PERIPLASMIC PROTEIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",9,"ASP A  15;LYS A  16;LYS A  43;GLU A  45;GLU A  46;ALA A  64;ASP A  66;ARG A  67;GLU A 112","MAL A 501 (-3.0A);MAL A 501 (-2.6A);None;None;None;MAL A 501 (-3.3A);MAL A 501 (-2.9A);MAL A 501 (-3.8A);MAL A 501 (-3.0A)","0.73A","3jyrA-4ifpA:61.5","3jyrA-4ifpA:81.67"],["3JYR_A_ACRA371_1","MALTOSE-BINDING PERIPLASMIC PROTEIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",10,"ASP A  15;LYS A  16;LYS A  43;GLU A  45;GLU A  46;ALA A  64;ASP A  66;GLU A 112;PRO A 155;TRP A 231","MAL A 501 (-3.0A);MAL A 501 (-2.6A);None;None;None;MAL A 501 (-3.3A);MAL A 501 (-2.9A);MAL A 501 (-3.0A);MAL A 501 (-3.4A);MAL A 501 (-4.4A)","0.41A","3jyrA-4ifpA:61.5","3jyrA-4ifpA:81.67"],["3JYR_A_ACRA371_2","MALTOSE-BINDING PERIPLASMIC PROTEIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",6,"ASN A  13;TRP A  63;GLU A 154;TYR A 156;MET A 331;TRP A 341","MAL A 501 ( 4.8A);MAL A 501 (-4.4A);MAL A 501 (-3.7A);MAL A 501 (-3.8A);MAL A 501 (-4.2A);MAL A 501 (-3.7A)","0.20A","3jyrA-4ifpA:61.5","3jyrA-4ifpA:81.67"],["3JYR_A_ACRA371_2","MALTOSE-BINDING PERIPLASMIC PROTEIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"TRP A  63;TYR A 156;MET A 331;TRP A 341;ARG A 345","MAL A 501 (-4.4A);MAL A 501 (-3.8A);MAL A 501 (-4.2A);MAL A 501 (-3.7A);None","0.68A","3jyrA-4ifpA:61.5","3jyrA-4ifpA:81.67"],["3K4V_B_ROCB201_4","HIV-1 PROTEASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"ARG A 345;ASP A 185;GLY A 167;THR A 158","None","1.17A","3k4vB-4ifpA:undetectable","3k4vB-4ifpA:14.55"],["3LCV_B_SAMB301_1","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",3,"ARG A 415;ASP A 394;GLN A 403","None","0.85A","3lcvB-4ifpA:undetectable","3lcvB-4ifpA:22.00"],["3N8Y_B_DIFB585_1","PROSTAGLANDIN G\/H SYNTHASE 1","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"VAL A 197;LEU A 161;GLY A 188;ALA A 189;LEU A 362","None","0.98A","3n8yB-4ifpA:undetectable","3n8yB-4ifpA:20.77"],["3O7W_A_SAMA801_1","LEUCINE CARBOXYL METHYLTRANSFERASE 1","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",3,"LYS A 421;ARG A 408;ASP A 208","None","1.29A","3o7wA-4ifpA:undetectable","3o7wA-4ifpA:20.84"],["3OZV_B_ECNB411_1","FLAVOHEMOGLOBIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"ILE A 162;GLN A 366;ALA A 363;LEU A 362;ALA A 163","None","1.09A","3ozvB-4ifpA:undetectable","3ozvB-4ifpA:23.42"],["3PGH_A_FLPA701_1","CYCLOOXYGENASE-2","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"VAL A 344;LEU A 161;GLY A 188;ALA A 189;LEU A 362","None","1.27A","3pghA-4ifpA:undetectable","3pghA-4ifpA:21.12"],["3TBG_B_RTZB1_1","CYTOCHROME P450 2D6","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"PHE A 157;GLY A 301;LEU A 300;GLU A 112;ALA A 232","None;None;None;MAL A 501 (-3.0A);None","0.82A","3tbgB-4ifpA:undetectable","3tbgB-4ifpA:21.58"],["3TBG_D_RTZD1_1","CYTOCHROME P450 2D6","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"PHE A 157;GLY A 301;LEU A 300;GLU A 112;ALA A 232","None;None;None;MAL A 501 (-3.0A);None","0.80A","3tbgD-4ifpA:undetectable","3tbgD-4ifpA:21.58"],["3VWQ_A_ACAA601_1","6-AMINOHEXANOATE-DIMER HYDROLASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"ALA A 232;TYR A  18;TYR A 211;ASN A 235;GLY A 229","None","1.37A","3vwqA-4ifpA:undetectable","3vwqA-4ifpA:21.55"],["3VWR_A_ACAA601_1","6-AMINOHEXANOATE-DIMER HYDROLASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"ALA A 232;ASP A 297;TYR A 211;ASN A 235;GLY A 229","None","1.30A","3vwrA-4ifpA:undetectable","3vwrA-4ifpA:21.34"],["4N48_A_SAMA601_1","CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"ASN A 268;ALA A  52;GLY A  57;ASP A  15","None;None;None;MAL A 501 (-3.0A)","0.96A","4n48A-4ifpA:undetectable","4n48A-4ifpA:21.17"],["4OR0_B_NPSB602_1","SERUM ALBUMIN","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"ALA A 265;ALA A 106;LEU A 104;LEU A 263;VAL A 262","None","1.16A","4or0B-4ifpA:undetectable","4or0B-4ifpA:22.76"],["4R87_J_SPMJ202_1","SPERMIDINE N1-ACETYLTRANSFERASE;SPERMIDINE N1-ACETYLTRANSFERASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",4,"TYR A 342;GLU A 380;GLU A  46;ARG A 345","None","1.29A","4r87J-4ifpA:undetectable;4r87L-4ifpA:undetectable","4r87J-4ifpA:16.48;4r87L-4ifpA:16.48"],["5IKT_B_TLFB601_0","PROSTAGLANDIN G\/H SYNTHASE 2","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"VAL A 344;LEU A 161;GLY A 188;ALA A 189;LEU A 362","None","1.18A","5iktB-4ifpA:undetectable","5iktB-4ifpA:20.55"],["5W4Z_A_RBFA502_1","RIBOFLAVIN LYASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",6,"ALA A 343;ALA A 339;GLY A 167;ALA A 189;PHE A 170;VAL A 182","None","1.38A","5w4zA-4ifpA:undetectable","5w4zA-4ifpA:10.57"],["5W4Z_B_RBFB502_1","RIBOFLAVIN LYASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",6,"ALA A 343;ALA A 339;GLY A 167;ALA A 189;PHE A 170;VAL A 182","None","1.40A","5w4zB-4ifpA:undetectable","5w4zB-4ifpA:10.57"],["6B58_A_ACTA603_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",3,"TYR A 156;ASN A 228;LEU A 114","MAL A 501 (-3.8A);None;None","0.82A","6b58A-4ifpA:undetectable","6b58A-4ifpA:23.14"],["6BM5_A_SAMA1301_0","METHIONINE SYNTHASE","4ifp","MALTOSE-BINDING PERIPLASMIC PROTEIN,NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1","Escherichia coli;Homo sapiens",5,"PRO A 134;GLU A 131;PRO A 255;ALA A 164;PRO A 160","None","1.38A","6bm5A-4ifpA:undetectable","6bm5A-4ifpA:22.00"]]