SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ifq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 784
ILE A 831
LEU A 876
ILE A 944
PHE A 832
 None
 1.15A 1bsxA-4ifqA:
undetectable		 1bsxA-4ifqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 784
ILE A 831
LEU A 876
ILE A 944
PHE A 832
 None
 1.15A 1bsxB-4ifqA:
undetectable		 1bsxB-4ifqA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  32
LEU A  29
LEU A  11
ILE A 135
LEU A 140
 None
 1.10A 1tw4B-4ifqA:
undetectable		 1tw4B-4ifqA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.97A 1v54A-4ifqA:
2.7
1v54J-4ifqA:
undetectable		 1v54A-4ifqA:
17.79
1v54J-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		6 / 12 PHE A 828
ILE A 783
ILE A 871
PHE A 713
PRO A 826
ALA A 824
 None
 1.49A 1vq1B-4ifqA:
undetectable		 1vq1B-4ifqA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 144
ALA A 147
LEU A  37
VAL A 121
LEU A 114
 None
 1.03A 1xiuB-4ifqA:
undetectable		 1xiuB-4ifqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.95A 2dyrA-4ifqA:
undetectable
2dyrJ-4ifqA:
undetectable		 2dyrA-4ifqA:
17.79
2dyrJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 1.00A 2dyrN-4ifqA:
3.5
2dyrW-4ifqA:
undetectable		 2dyrN-4ifqA:
17.79
2dyrW-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.92A 2dysA-4ifqA:
undetectable
2dysJ-4ifqA:
undetectable		 2dysA-4ifqA:
17.79
2dysJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 1.01A 2eijA-4ifqA:
2.6
2eijJ-4ifqA:
undetectable		 2eijA-4ifqA:
17.79
2eijJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.97A 2eilA-4ifqA:
undetectable
2eilJ-4ifqA:
undetectable		 2eilA-4ifqA:
17.79
2eilJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 836
PHE A 713
ILE A 717
ILE A 749
LEU A 788
 None
 1.08A 2rlcA-4ifqA:
undetectable		 2rlcA-4ifqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 546
TYR A 508
SER A 505
GLN A 440
 None
 1.14A 2xz5B-4ifqA:
undetectable
2xz5E-4ifqA:
undetectable		 2xz5B-4ifqA:
12.92
2xz5E-4ifqA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.91A 2zxwA-4ifqA:
undetectable
2zxwJ-4ifqA:
undetectable		 2zxwA-4ifqA:
17.79
2zxwJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.86A 3ablA-4ifqA:
2.6
3ablJ-4ifqA:
undetectable		 3ablA-4ifqA:
17.79
3ablJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.90A 3abmA-4ifqA:
undetectable
3abmJ-4ifqA:
undetectable		 3abmA-4ifqA:
17.79
3abmJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.94A 3ag3N-4ifqA:
undetectable
3ag3W-4ifqA:
undetectable		 3ag3N-4ifqA:
17.79
3ag3W-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.94A 3asnA-4ifqA:
2.6
3asnJ-4ifqA:
undetectable		 3asnA-4ifqA:
17.79
3asnJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 0.93A 3asoA-4ifqA:
undetectable
3asoJ-4ifqA:
undetectable		 3asoA-4ifqA:
17.79
3asoJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  56
LEU A  93
ILE A  92
ILE A  75
PHE A  70
 None
 1.07A 3b2rA-4ifqA:
undetectable		 3b2rA-4ifqA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  56
LEU A  93
ILE A  92
ILE A  75
PHE A  70
 None
 1.05A 3b2rB-4ifqA:
undetectable		 3b2rB-4ifqA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 556
LYS A 633
VAL A 634
 None
 1.11A 3brfA-4ifqA:
undetectable		 3brfA-4ifqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 263
GLY A 317
LEU A 355
ILE A 278
ILE A 231
 None
 1.07A 3frqB-4ifqA:
undetectable		 3frqB-4ifqA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 SER A 433
PHE A 430
ASP A 202
TYR A 198
 None
 1.18A 3jq7B-4ifqA:
undetectable		 3jq7B-4ifqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 SER A 433
PHE A 430
ASP A 202
TYR A 198
 None
 1.16A 3jqaA-4ifqA:
undetectable		 3jqaA-4ifqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 SER A 433
PHE A 430
ASP A 202
TYR A 198
 None
 1.13A 3jqaB-4ifqA:
undetectable		 3jqaB-4ifqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 SER A 433
PHE A 430
ASP A 202
TYR A 198
 None
 1.13A 3jqaC-4ifqA:
undetectable		 3jqaC-4ifqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 SER A 433
PHE A 430
ASP A 202
TYR A 198
 None
 1.12A 3jqaD-4ifqA:
undetectable		 3jqaD-4ifqA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 141
LEU A 140
TYR A 131
ILE A 196
GLY A 199
 None
 1.18A 3n8yA-4ifqA:
0.6		 3n8yA-4ifqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 113
LEU A  32
LEU A  11
ILE A 206
GLY A 199
 None
 1.13A 3ozwB-4ifqA:
2.1		 3ozwB-4ifqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 788
CYH A 789
PHE A 828
TYR A 793
 None
 0.99A 3po7A-4ifqA:
undetectable		 3po7A-4ifqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 133
PHE A  25
GLN A  33
 None
 0.68A 3r55A-4ifqA:
undetectable		 3r55A-4ifqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 238
PHE A 325
ALA A 326
THR A 329
 None
 1.15A 3t3sB-4ifqA:
undetectable		 3t3sB-4ifqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 440
PHE A 499
TYR A 489
 None
 0.87A 3ucjB-4ifqA:
undetectable		 3ucjB-4ifqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 440
PHE A 499
TYR A 489
 None
 0.87A 3ucjA-4ifqA:
undetectable		 3ucjA-4ifqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 449
ALA A 283
ILE A 286
LYS A 452
 None
None
None
SO4  A1003 (-3.3A)
 1.37A 4eixA-4ifqA:
undetectable		 4eixA-4ifqA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 713
PHE A 709
PHE A 753
LEU A 675
 None
 1.05A 4ejgA-4ifqA:
undetectable		 4ejgA-4ifqA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 609
LEU A 612
LEU A 639
ILE A 569
ILE A 645
 None
 1.14A 4j24A-4ifqA:
undetectable		 4j24A-4ifqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 609
LEU A 612
LEU A 639
ILE A 569
ILE A 645
 None
 1.16A 4j24B-4ifqA:
undetectable		 4j24B-4ifqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 837
ILE A 840
ASN A 919
ILE A 872
 None
 0.97A 4jtpA-4ifqA:
undetectable		 4jtpA-4ifqA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 782
LEU A 781
GLU A 863
LEU A 864
 IOD  A1008 ( 4.1A)
None
None
None
 1.24A 4k4yA-4ifqA:
2.3		 4k4yA-4ifqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 782
LEU A 781
GLU A 863
LEU A 864
 IOD  A1008 ( 4.1A)
None
None
None
 1.25A 4k4yI-4ifqA:
2.4		 4k4yI-4ifqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 947
SER A 941
ARG A 943
VAL A 869
 None
 1.18A 4l64A-4ifqA:
2.1		 4l64A-4ifqA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 901
ASN A 829
HIS A 907
 None
 0.97A 4ma3H-4ifqA:
undetectable
4ma3L-4ifqA:
undetectable		 4ma3H-4ifqA:
13.05
4ma3L-4ifqA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 145
LEU A 193
LEU A 216
ASN A  36
 None
 0.96A 4n09B-4ifqA:
undetectable		 4n09B-4ifqA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 186
ASN A  36
GLN A 111
LEU A 114
 None
 1.17A 4nc3A-4ifqA:
2.1		 4nc3A-4ifqA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 770
ASP A 769
ARG A 771
GLY A 857
 None
 1.04A 4oltA-4ifqA:
undetectable		 4oltA-4ifqA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 831
LEU A 761
ALA A 762
PHE A 757
ILE A 783
ILE A 827
 None
 1.46A 4pssA-4ifqA:
undetectable		 4pssA-4ifqA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  36
LEU A  37
LEU A 145
LEU A 216
ALA A 236
 None
 1.31A 4rtbA-4ifqA:
undetectable		 4rtbA-4ifqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 450
ASP A 455
GLU A 457
ILE A 511
 None
 0.78A 4xi3C-4ifqA:
undetectable		 4xi3C-4ifqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 557
LYS A 556
LEU A 613
PHE A 341
 None
 1.24A 4yv5A-4ifqA:
undetectable		 4yv5A-4ifqA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 535
ALA A 490
PRO A 493
LEU A 533
 None
 1.03A 5dzkD-4ifqA:
undetectable
5dzkR-4ifqA:
undetectable		 5dzkD-4ifqA:
12.20
5dzkR-4ifqA:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 836
LEU A 909
GLY A 908
PHE A 832
 None
 0.92A 5kmdC-4ifqA:
3.7
5kmdD-4ifqA:
3.8		 5kmdC-4ifqA:
15.26
5kmdD-4ifqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  37
LEU A  35
ASN A  36
LEU A 200
LEU A 145
 None
 1.15A 5mwyA-4ifqA:
undetectable		 5mwyA-4ifqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  58
VAL A  66
PHE A  70
ILE A  92
THR A  97
 None
 1.41A 5w8aA-4ifqA:
undetectable		 5w8aA-4ifqA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 675
ARG A 693
THR A 697
LEU A 700
 None
 1.05A 5x1fA-4ifqA:
undetectable
5x1fJ-4ifqA:
undetectable		 5x1fA-4ifqA:
17.79
5x1fJ-4ifqA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 263
VAL A 275
THR A 311
PHE A 448
THR A 451
 None
None
SO4  A1003 ( 4.4A)
None
None
 1.47A 5xipD-4ifqA:
undetectable		 5xipD-4ifqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
PHE A 229
LEU A 114
ILE A 144
LEU A 360
 None
 1.22A 5y2tA-4ifqA:
undetectable		 5y2tA-4ifqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 887
VAL A 875
PRO A 826
VAL A 890
 None
 1.30A 6ekzA-4ifqA:
undetectable		 6ekzA-4ifqA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 676
ILE A 679
ARG A 745
ASN A 694
 None
 1.23A 6hisA-4ifqA:
3.3
6hisB-4ifqA:
3.5		 6hisA-4ifqA:
6.20
6hisB-4ifqA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 676
ILE A 679
ARG A 745
ASN A 694
 None
 1.23A 6hisB-4ifqA:
3.5
6hisC-4ifqA:
3.5		 6hisB-4ifqA:
6.20
6hisC-4ifqA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 676
ILE A 679
ARG A 745
ASN A 694
 None
 1.22A 6hisC-4ifqA:
3.5
6hisD-4ifqA:
3.4		 6hisC-4ifqA:
6.20
6hisD-4ifqA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 676
ILE A 679
ARG A 745
ASN A 694
 None
 1.23A 6hisD-4ifqA:
3.4
6hisE-4ifqA:
3.4		 6hisD-4ifqA:
6.20
6hisE-4ifqA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4ifq NUCLEOPORIN NUP192
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 694
ASP A 676
ILE A 679
ARG A 745
 None
 1.23A 6hisA-4ifqA:
3.4
6hisE-4ifqA:
3.5		 6hisA-4ifqA:
6.20
6hisE-4ifqA:
6.20