SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ifs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		5 / 9 LEU A 242
LEU A 275
ILE A 216
VAL A 317
MET A 318
 None
 1.38A 1gx8A-4ifsA:
undetectable		 1gx8A-4ifsA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		4 / 6 HIS A 363
GLN A 252
LEU A 208
LEU A 276
 None
 0.83A 3bgdA-4ifsA:
undetectable		 3bgdA-4ifsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		4 / 7 HIS A 363
GLN A 252
LEU A 208
LEU A 276
 None
 0.77A 3bgdB-4ifsA:
undetectable		 3bgdB-4ifsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		3 / 3 GLU A 394
GLY A 398
SER A 375
 None
 0.64A 4b53B-4ifsA:
undetectable		 4b53B-4ifsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		4 / 5 PHE A 391
PHE A 415
PHE A 379
VAL A 418
 None
 1.10A 5a1rA-4ifsA:
undetectable		 5a1rA-4ifsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		4 / 5 PRO A 366
LEU A 205
TYR A 232
PHE A 230
 None
 1.50A 5igjA-4ifsA:
undetectable		 5igjA-4ifsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		5 / 10 TYR A 214
TYR A 232
ILE A 263
ILE A 234
ILE A 257
 None
 1.42A 5mvnD-4ifsA:
undetectable		 5mvnD-4ifsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		5 / 10 TYR A 214
TYR A 232
ILE A 263
ILE A 234
ILE A 257
 None
 1.36A 5mzrA-4ifsA:
undetectable		 5mzrA-4ifsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		5 / 10 TYR A 214
TYR A 232
ILE A 263
ILE A 234
ILE A 257
 None
 1.36A 5mzrC-4ifsA:
undetectable		 5mzrC-4ifsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4ifs FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens) 		5 / 12 LEU A 352
ILE A 341
VAL A 418
ASP A 390
PHE A 379
 None
 1.22A 5vlmG-4ifsA:
undetectable		 5vlmG-4ifsA:
20.90