SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ig8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		3 / 3 LYS A 222
GLU A 322
TRP A 215
 None
 1.26A 3v4tH-4ig8A:
undetectable		 3v4tH-4ig8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		4 / 6 SER A  64
GLU A 233
ASP A 300
ASP A  77
 None
DTP  A 403 ( 4.2A)
None
MG  A 402 (-2.6A)
 1.22A 4blvA-4ig8A:
undetectable		 4blvA-4ig8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		4 / 9 PHE A  40
CYH A  45
PHE A 119
ILE A  99
 None
 1.19A 4jvlA-4ig8A:
undetectable		 4jvlA-4ig8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		3 / 3 TYR A 216
GLN A 318
TRP A 326
 None
 1.11A 4kn2C-4ig8A:
undetectable		 4kn2C-4ig8A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		5 / 11 VAL A  55
VAL A  80
VAL A  58
ILE A  37
PHE A  40
 G  B  17 ( 4.2A)
None
A  C   3 ( 4.3A)
None
None
 1.08A 5e4dB-4ig8A:
undetectable		 5e4dB-4ig8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		4 / 7 CYH A  38
ILE A  36
LEU A  78
ALA A  76
 U  C   4 ( 3.3A)
None
None
None
 0.95A 5hrqE-4ig8A:
undetectable
5hrqF-4ig8A:
undetectable
5hrqJ-4ig8A:
undetectable		 5hrqE-4ig8A:
7.85
5hrqF-4ig8A:
8.28
5hrqJ-4ig8A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A  69
SER A  64
ASP A 148
 None
None
MG  A 401 (-3.2A)
 0.52A 5kvaA-4ig8A:
undetectable		 5kvaA-4ig8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4ig8 2'-5'-OLIGOADENYLATE
SYNTHASE 1
(Homo
sapiens) 		3 / 3 THR A  69
SER A  64
ASP A 148
 None
None
MG  A 401 (-3.2A)
 0.50A 5kvaB-4ig8A:
undetectable		 5kvaB-4ig8A:
19.66