SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ig9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 PHE A 366
ILE A 347
PHE A 297
PHE A 413
 None
 0.80A 1fslB-4ig9A:
undetectable		 1fslB-4ig9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.10A 1n6cA-4ig9A:
undetectable		 1n6cA-4ig9A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 6 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
 None
 0.24A 1yc2A-4ig9A:
23.8		 1yc2A-4ig9A:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ALA A 262
ASN A 346
ILE A 347
ASP A 348
 None
 0.34A 1yc2D-4ig9A:
24.1		 1yc2D-4ig9A:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.52A 1yc2E-4ig9A:
21.4		 1yc2E-4ig9A:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 7 ALA A 262
SER A 265
ASN A 346
ILE A 347
ASP A 348
 None
 0.27A 1yc5A-4ig9A:
21.8		 1yc5A-4ig9A:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 7 SER A 265
ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.62A 1yc5A-4ig9A:
21.8		 1yc5A-4ig9A:
34.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 PHE A 287
PRO A 288
ASP A 289
TYR A 301
 None
 1.01A 2aouB-4ig9A:
2.3		 2aouB-4ig9A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ALA A 262
ASN A 346
ILE A 347
ASP A 348
 None
 0.32A 2h4jA-4ig9A:
21.5		 2h4jA-4ig9A:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.67A 2h4jA-4ig9A:
21.5		 2h4jA-4ig9A:
34.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 PRO A 308
PHE A 310
PHE A 309
ILE A 406
 None
 1.14A 2hjhA-4ig9A:
26.1		 2hjhA-4ig9A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 LEU A 493
VAL A 258
ILE A 464
PHE A 329
 None
 0.94A 2weyB-4ig9A:
undetectable		 2weyB-4ig9A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 8 GLN A 352
ILE A 356
ASP A 348
SER A 265
 None
 1.08A 2xytE-4ig9A:
undetectable		 2xytE-4ig9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 ILE A 485
SER A 324
GLY A 440
GLY A 263
LEU A 463
 None
 0.92A 2zw9A-4ig9A:
undetectable		 2zw9A-4ig9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.12A 4e47A-4ig9A:
undetectable		 4e47A-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.13A 4e47B-4ig9A:
undetectable		 4e47B-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.10A 4e47C-4ig9A:
undetectable		 4e47C-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.15A 4jdsA-4ig9A:
undetectable		 4jdsA-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.15A 4jdsB-4ig9A:
undetectable		 4jdsB-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.14A 4jdsC-4ig9A:
undetectable		 4jdsC-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.14A 4jlgA-4ig9A:
undetectable		 4jlgA-4ig9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 12 CYH A 253
GLN A 461
VAL A 433
ILE A 257
LEU A 339
 None
 1.50A 4k38B-4ig9A:
undetectable		 4k38B-4ig9A:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.51A 4rmjA-4ig9A:
27.7		 4rmjA-4ig9A:
40.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.98A 4w5oA-4ig9A:
2.2		 4w5oA-4ig9A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.98A 4z4eA-4ig9A:
2.5		 4z4eA-4ig9A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 7 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.99A 4z4gA-4ig9A:
2.5		 4z4gA-4ig9A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		5 / 11 ALA A 262
GLY A 263
ASN A 342
ASN A 346
HIS A 363
 None
 1.10A 5ayfA-4ig9A:
undetectable		 5ayfA-4ig9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens) 		4 / 5 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.98A 5ki6A-4ig9A:
2.1		 5ki6A-4ig9A:
15.75