SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4igb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 5 ASP D 261
SER D 260
ASN D 238
SER D 264
 None
 1.40A 1kiaB-4igbD:
undetectable		 1kiaB-4igbD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 6 ASP D 261
SER D 260
ASN D 238
SER D 264
 None
 1.40A 1kiaC-4igbD:
undetectable		 1kiaC-4igbD:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		3 / 3 ASP D 198
PHE D 234
ASN D 238
 None
 0.84A 1sg9B-4igbD:
undetectable		 1sg9B-4igbD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 11 THR D 418
VAL D 450
VAL D 321
ASN D 434
ILE D 432
 None
 1.42A 1t6zB-4igbD:
undetectable		 1t6zB-4igbD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 ALA D 201
GLY D 307
LEU D 215
SER D 287
LEU D 350
 None
 0.98A 1ya4A-4igbD:
undetectable		 1ya4A-4igbD:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 LEU D 283
GLY D 282
ILE D 222
ASP D 221
ASN D 249
 None
None
None
SO4  D 502 ( 2.8A)
None
 1.05A 3cjtK-4igbD:
undetectable		 3cjtK-4igbD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 LEU D 283
GLY D 282
ILE D 222
ASP D 223
ASN D 249
 None
None
None
SO4  D 502 (-3.2A)
None
 1.19A 3cjtK-4igbD:
undetectable		 3cjtK-4igbD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 GLU D 232
ILE D 222
SER D 281
GLY D 282
THR D 271
 NA  D 504 (-2.7A)
None
None
None
None
 1.32A 3r75A-4igbD:
undetectable		 3r75A-4igbD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 GLU D 232
ILE D 222
SER D 281
GLY D 282
THR D 271
 NA  D 504 (-2.7A)
None
None
None
None
 1.30A 3r75B-4igbD:
undetectable		 3r75B-4igbD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 11 GLU D 232
ILE D 222
SER D 281
GLY D 282
THR D 271
 NA  D 504 (-2.7A)
None
None
None
None
 1.35A 3r76A-4igbD:
undetectable		 3r76A-4igbD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 11 GLU D 232
ILE D 222
SER D 281
GLY D 282
THR D 271
 NA  D 504 (-2.7A)
None
None
None
None
 1.36A 3r76B-4igbD:
undetectable		 3r76B-4igbD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		3 / 3 ASN D 293
ASP D 198
ASN D 135
 None
 0.52A 4agaA-4igbD:
undetectable		 4agaA-4igbD:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 8 MET D 399
ILE D 414
PRO D 353
VAL D 342
 None
 1.29A 4f4dB-4igbD:
undetectable		 4f4dB-4igbD:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 MET D 399
LEU D 438
ILE D 413
ILE D 414
LEU D 380
 None
 1.29A 4j24C-4igbD:
undetectable		 4j24C-4igbD:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 5 TYR D 416
THR D 394
PHE D 362
ILE D 388
 None
 1.09A 4jx1E-4igbD:
undetectable		 4jx1E-4igbD:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 6 PHE D 109
PHE D 173
SER D  69
VAL D  70
 None
 1.20A 5hesA-4igbD:
undetectable		 5hesA-4igbD:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 LEU D 283
LEU D 285
PHE D 306
GLU D 169
ALA D 304
 None
None
None
SO4  D 501 ( 4.2A)
NA  D 504 ( 4.5A)
 1.21A 5ieoA-4igbD:
1.5		 5ieoA-4igbD:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 5 PHE D 162
LEU D  56
GLY D 307
ILE D 175
 None
 1.00A 5ik1A-4igbD:
undetectable		 5ik1A-4igbD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 8 LEU D 115
ALA D 197
VAL D  61
GLN D  72
 None
 0.96A 5nu7A-4igbD:
undetectable		 5nu7A-4igbD:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		4 / 5 LEU D 308
PHE D 306
PHE D 173
LEU D 132
 None
 1.12A 5x1bP-4igbD:
undetectable		 5x1bP-4igbD:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 GLY D 282
ASN D 276
ASP D 221
ILE D 222
LEU D 254
 None
None
SO4  D 502 ( 2.8A)
None
None
 1.18A 6b3aA-4igbD:
undetectable		 6b3aA-4igbD:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		5 / 12 GLY D 282
ASN D 276
ASP D 221
ILE D 222
LEU D 254
 None
None
SO4  D 502 ( 2.8A)
None
None
 1.16A 6b3bA-4igbD:
undetectable		 6b3bA-4igbD:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4igb LPXTG CELL WALL
SURFACE PROTEIN
(Streptococcus
gordonii) 		3 / 3 TRP D 194
ILE D 195
ASP D 196
 None
 0.76A 6i0y7-4igbD:
undetectable		 6i0y7-4igbD:
7.08