SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4igd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 LEU A 540
TYR A 544
HIS A 493
THR A 665
 None
 1.26A 1afsA-4igdA:
undetectable		 1afsA-4igdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 LEU A 540
TYR A 544
HIS A 493
THR A 665
 None
 1.25A 1afsB-4igdA:
undetectable		 1afsB-4igdA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		3 / 3 ALA A 416
VAL A 419
TRP A 420
 None
 0.97A 1c4dA-4igdA:
undetectable
1c4dB-4igdA:
undetectable		 1c4dA-4igdA:
5.77
1c4dB-4igdA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		3 / 3 LEU A 524
LEU A 601
MET A 602
 None
 0.83A 2itzA-4igdA:
undetectable		 2itzA-4igdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 SER A 646
VAL A 666
TRP A 668
GLY A 679
TYR A 681
 None
None
GOL  A 702 (-3.9A)
None
None
 0.52A 2p16A-4igdA:
28.9		 2p16A-4igdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 LEU A 304
TYR A 319
ILE A 347
ILE A 312
 None
 0.86A 2q8hA-4igdA:
undetectable		 2q8hA-4igdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		6 / 12 SER A 646
VAL A 666
TRP A 668
GLY A 673
GLY A 679
TYR A 681
 None
None
GOL  A 702 (-3.9A)
None
None
None
 0.75A 2w26A-4igdA:
28.9		 2w26A-4igdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 9 VAL A 486
GLY A 476
GLY A 648
ILE A 571
LEU A 479
 None
 0.93A 2z0yA-4igdA:
undetectable		 2z0yA-4igdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 MET A 650
LEU A 662
GLY A 647
GLY A 648
TRP A 668
 None
None
None
None
GOL  A 702 (-3.9A)
 1.21A 3i5uA-4igdA:
undetectable		 3i5uA-4igdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 SER A 646
VAL A 666
TRP A 668
GLY A 679
 None
None
GOL  A 702 (-3.9A)
None
 0.32A 3rxfA-4igdA:
9.2		 3rxfA-4igdA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 THR A 460
PRO A 461
PRO A 649
ILE A 684
VAL A 486
 None
 1.05A 4eb6B-4igdA:
undetectable
4eb6C-4igdA:
undetectable		 4eb6B-4igdA:
20.83
4eb6C-4igdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 ILE A 463
GLY A 644
GLY A 588
ILE A 604
ASP A 640
 None
 0.94A 4iv0B-4igdA:
undetectable		 4iv0B-4igdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 ILE A 463
GLY A 648
ILE A 606
VAL A 651
 None
 0.77A 4r21A-4igdA:
undetectable		 4r21A-4igdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 9 ALA A 643
ILE A 463
GLY A 648
ILE A 606
VAL A 651
 None
 0.84A 4r21B-4igdA:
undetectable		 4r21B-4igdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		5 / 12 LEU A 373
GLY A 410
SER A 391
PHE A 380
THR A 382
 None
 1.25A 5d0yA-4igdA:
undetectable		 5d0yA-4igdA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 7 LEU A 479
GLU A 557
ILE A 684
VAL A 486
 None
 1.20A 5jh7C-4igdA:
undetectable		 5jh7C-4igdA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 HIS A 375
LEU A 564
PRO A 562
SER A 483
 None
 1.30A 5syjA-4igdA:
undetectable		 5syjA-4igdA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 6 HIS A 375
LEU A 564
PRO A 562
SER A 483
 None
 1.29A 5syjB-4igdA:
undetectable		 5syjB-4igdA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 GLU A 557
THR A 695
THR A 487
LEU A 540
 None
 1.33A 5v96A-4igdA:
undetectable		 5v96A-4igdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 GLU A 557
THR A 695
THR A 487
LEU A 540
 None
 1.36A 5v96B-4igdA:
undetectable		 5v96B-4igdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 GLU A 557
THR A 695
THR A 487
LEU A 540
 None
 1.34A 5v96C-4igdA:
undetectable		 5v96C-4igdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 4 GLU A 557
THR A 695
THR A 487
LEU A 540
 None
 1.34A 5v96D-4igdA:
undetectable		 5v96D-4igdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens) 		4 / 5 SER A 328
VAL A 327
LYS A 311
PRO A 314
 None
 0.86A 6fi4A-4igdA:
undetectable
6fi4B-4igdA:
undetectable		 6fi4A-4igdA:
19.90
6fi4B-4igdA:
4.10