SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4igg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 5 PHE A 301
TYR A 351
LEU A 364
ASP A 292
 None
 1.43A 1dz6A-4iggA:
undetectable		 1dz6A-4iggA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 ALA A 468
LEU A 243
ALA A 239
PHE A 487
ILE A 465
 None
 1.23A 1g5yB-4iggA:
undetectable		 1g5yB-4iggA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 6 ILE A 632
VAL A 629
VAL A 390
ILE A 505
ASP A 510
 None
 1.32A 1uwhA-4iggA:
undetectable		 1uwhA-4iggA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 6 THR A 727
GLU A 725
MET A 826
ILE A 749
 None
 1.33A 2w98B-4iggA:
undetectable		 2w98B-4iggA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 6 THR A 727
MET A 826
LYS A 717
ILE A 749
 None
 1.35A 2w98B-4iggA:
undetectable		 2w98B-4iggA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		3 / 3 ARG A 626
GLU A 516
SER A 846
 None
 0.86A 2xctD-4iggA:
3.2		 2xctD-4iggA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 GLY A 805
ASN A 284
GLY A 804
GLY A 272
ASP A 200
 None
 1.03A 3huoB-4iggA:
undetectable		 3huoB-4iggA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 ALA A 320
ARG A 380
LEU A 382
ILE A 312
LEU A 282
 None
 1.11A 3k2hB-4iggA:
undetectable		 3k2hB-4iggA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 1.04A 3ko0A-4iggA:
undetectable
3ko0B-4iggA:
undetectable
3ko0C-4iggA:
undetectable
3ko0D-4iggA:
undetectable		 3ko0A-4iggA:
9.16
3ko0B-4iggA:
9.16
3ko0C-4iggA:
9.16
3ko0D-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 1.04A 3ko0G-4iggA:
1.4
3ko0H-4iggA:
1.4
3ko0I-4iggA:
1.4
3ko0J-4iggA:
1.4		 3ko0G-4iggA:
9.16
3ko0H-4iggA:
9.16
3ko0I-4iggA:
9.16
3ko0J-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 0.99A 3ko0K-4iggA:
undetectable
3ko0L-4iggA:
undetectable
3ko0S-4iggA:
undetectable
3ko0T-4iggA:
undetectable		 3ko0K-4iggA:
9.16
3ko0L-4iggA:
9.16
3ko0S-4iggA:
9.16
3ko0T-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 GLU A 350
LEU A 347
ASP A 346
LEU A 364
ILE A 368
 None
 1.04A 3ko0K-4iggA:
undetectable
3ko0L-4iggA:
undetectable
3ko0M-4iggA:
undetectable
3ko0N-4iggA:
undetectable		 3ko0K-4iggA:
9.16
3ko0L-4iggA:
9.16
3ko0M-4iggA:
9.16
3ko0N-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 364
ILE A 368
GLU A 350
LEU A 347
ASP A 346
 None
 1.01A 3ko0M-4iggA:
undetectable
3ko0N-4iggA:
undetectable
3ko0O-4iggA:
undetectable
3ko0P-4iggA:
undetectable		 3ko0M-4iggA:
9.16
3ko0N-4iggA:
9.16
3ko0O-4iggA:
9.16
3ko0P-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 GLU A 350
LEU A 347
ASP A 346
LEU A 364
ILE A 368
 None
 1.01A 3ko0M-4iggA:
undetectable
3ko0N-4iggA:
undetectable
3ko0O-4iggA:
undetectable
3ko0P-4iggA:
undetectable		 3ko0M-4iggA:
9.16
3ko0N-4iggA:
9.16
3ko0O-4iggA:
9.16
3ko0P-4iggA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 318
GLY A 315
SER A 314
LEU A 382
ALA A 335
 None
 1.28A 3ou6C-4iggA:
undetectable		 3ou6C-4iggA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 318
GLY A 315
SER A 314
LEU A 382
ALA A 335
 None
 1.29A 3ou7C-4iggA:
undetectable		 3ou7C-4iggA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		3 / 3 GLN A 206
ASP A 200
GLN A 271
 None
 0.69A 4aztA-4iggA:
undetectable		 4aztA-4iggA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 8 ASP A 265
SER A 264
SER A 268
GLY A 272
 None
 0.67A 4fo4A-4iggA:
undetectable		 4fo4A-4iggA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 8 ARG A 383
ASP A 757
ASP A 509
ASP A 510
 None
 1.16A 4xqgA-4iggA:
undetectable		 4xqgA-4iggA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 8 ARG A 383
ASP A 757
ASP A 509
ASP A 510
 None
 1.16A 4xqgB-4iggA:
undetectable		 4xqgB-4iggA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 4 ASN A 791
MET A 723
MET A 726
TYR A 786
 None
 0.94A 5uc3B-4iggA:
0.5		 5uc3B-4iggA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		4 / 4 LEU A 278
GLY A 315
SER A 314
SER A 311
 None
 1.37A 5uunA-4iggA:
0.7		 5uunA-4iggA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		3 / 3 ARG A 548
ILE A 519
SER A 515
 None
 0.54A 5zw2A-4iggA:
2.2		 5zw2A-4iggA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 364
ASN A 365
PHE A 301
ASP A 292
ILE A 792
 None
 1.45A 6dwnB-4iggA:
undetectable		 6dwnB-4iggA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 GLY A 621
ILE A 625
THR A 576
ILE A 545
ILE A 519
 None
 0.98A 6emuB-4iggA:
undetectable		 6emuB-4iggA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4igg CATENIN ALPHA-1
(Homo
sapiens) 		5 / 12 GLY A 621
ILE A 625
THR A 576
ILE A 545
ILE A 519
 None
 0.93A 6emuC-4iggA:
undetectable		 6emuC-4iggA:
13.09