SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4igi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 7 SER A1141
THR A1105
ASN A1104
TYR A1069
 None
 0.93A 1dssG-4igiA:
4.1		 1dssG-4igiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 8 SER A1141
THR A1105
ASN A1104
TYR A1069
 None
 0.92A 1dssR-4igiA:
4.5		 1dssR-4igiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 4 THR A1105
LEU A1109
VAL A1112
LEU A1117
 None
 0.68A 1fbmD-4igiA:
undetectable		 1fbmD-4igiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 6 GLY A1087
ILE A1089
GLN A1085
VAL A1064
 None
 0.91A 1rs7B-4igiA:
undetectable		 1rs7B-4igiA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		5 / 12 GLY A1163
GLY A1165
ILE A1169
LEU A1191
GLU A1190
 None
 1.08A 3ckkA-4igiA:
2.8		 3ckkA-4igiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 8 SER A1141
THR A1105
ASN A1104
TYR A1069
 None
 0.81A 3dmtC-4igiA:
4.1		 3dmtC-4igiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		3 / 3 ARG A1038
GLU A1139
ASP A1143
 None
 0.92A 3g2oA-4igiA:
undetectable		 3g2oA-4igiA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		3 / 3 ASP A1032
GLU A1171
SER A1039
 None
 0.80A 3p2kA-4igiA:
undetectable		 3p2kA-4igiA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 6 LEU A1055
VAL A1052
PHE A1029
PHE A1077
 None
 1.11A 3soaA-4igiA:
undetectable		 3soaA-4igiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 6 GLY A1087
ILE A1089
GLN A1085
VAL A1064
 None
 0.94A 4d39B-4igiA:
undetectable		 4d39B-4igiA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		5 / 12 ILE A1164
ALA A1167
SER A1176
ILE A1160
PRO A1159
 None
 1.37A 4gh8B-4igiA:
undetectable		 4gh8B-4igiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 4 LEU A1136
LEU A1133
GLN A1049
GLU A1076
 None
 0.82A 4i41A-4igiA:
undetectable		 4i41A-4igiA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 6 GLY A1087
ILE A1089
GLN A1085
VAL A1064
 None
 0.97A 4kcnA-4igiA:
undetectable		 4kcnA-4igiA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 5 PHE A1188
LEU A1097
GLY A1033
ILE A1164
 None
 1.01A 5ik1A-4igiA:
undetectable		 5ik1A-4igiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		5 / 12 ARG A1093
LEU A1095
PHE A1077
ILE A1031
PHE A1029
 None
 1.09A 5veuA-4igiA:
undetectable		 5veuA-4igiA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		5 / 9 VAL A1197
LEU A1136
GLY A1192
LEU A1191
VAL A1051
 None
 1.27A 6czmA-4igiA:
undetectable
6czmB-4igiA:
undetectable		 6czmA-4igiA:
21.17
6czmB-4igiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		5 / 9 VAL A1197
LEU A1136
GLY A1192
LEU A1191
VAL A1051
 None
 1.31A 6czmB-4igiA:
undetectable
6czmC-4igiA:
undetectable		 6czmB-4igiA:
21.17
6czmC-4igiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		5 / 9 VAL A1197
LEU A1136
GLY A1192
LEU A1191
VAL A1051
 None
 1.28A 6czmD-4igiA:
undetectable
6czmE-4igiA:
undetectable		 6czmD-4igiA:
21.17
6czmE-4igiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4igi COLLAGEN ALPHA3(VI)
(Mus
musculus) 		4 / 6 LEU A1210
VAL A1048
PHE A1177
GLY A1156
 None
 0.93A 6hd4B-4igiA:
undetectable		 6hd4B-4igiA:
15.35