SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4igl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4igl YENB
YENC2
(Yersinia
entomophaga) 		3 / 3 ASP A 990
ARG B  23
ILE B  41
 None
 0.80A 1a4gB-4iglA:
2.8		 1a4gB-4iglA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 GLY A 716
ASN A 713
GLY A1360
VAL A  28
 None
 0.70A 1dbbH-4iglA:
undetectable
1dbbL-4iglA:
undetectable		 1dbbH-4iglA:
9.65
1dbbL-4iglA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 SER A 921
VAL A 919
ARG A  82
ALA A 105
 None
 1.13A 1dmiA-4iglA:
undetectable
1dmiB-4iglA:
undetectable		 1dmiA-4iglA:
15.77
1dmiB-4iglA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ALA A1373
VAL A1371
TRP A1402
 None
 0.84A 1gmkA-4iglA:
undetectable
1gmkB-4iglA:
undetectable		 1gmkA-4iglA:
0.96
1gmkB-4iglA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ALA A1373
VAL A1371
TRP A1402
 None
 0.86A 1gmkC-4iglA:
undetectable
1gmkD-4iglA:
undetectable		 1gmkC-4iglA:
0.96
1gmkD-4iglA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 ASN A 243
LEU A 264
ALA A 324
LEU A 325
 None
 1.04A 1hwiB-4iglA:
undetectable		 1hwiB-4iglA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 ASN A 243
LEU A 264
ALA A 324
LEU A 325
 None
 1.05A 1hwiC-4iglA:
undetectable		 1hwiC-4iglA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 ALA A 460
LEU A 533
LEU A 501
LEU A 525
 None
 0.96A 1mt1D-4iglA:
undetectable
1mt1E-4iglA:
undetectable		 1mt1D-4iglA:
5.24
1mt1E-4iglA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 LEU A 462
VAL A 474
VAL A 516
LEU A 501
HIS A 507
 None
 1.40A 1mx1E-4iglA:
undetectable		 1mx1E-4iglA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 ASN B 446
ARG B 447
ASP B  57
GLY B 670
ARG B 650
 None
 1.31A 1q8jA-4iglB:
undetectable		 1q8jA-4iglB:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4igl YENC2
(Yersinia
entomophaga) 		5 / 10 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.26A 1qftA-4iglB:
0.0		 1qftA-4iglB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB177_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4igl YENC2
(Yersinia
entomophaga) 		5 / 10 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.34A 1qftB-4iglB:
1.8		 1qftB-4iglB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4igl YENC2
(Yersinia
entomophaga) 		5 / 10 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.27A 1qfvA-4iglB:
1.0		 1qfvA-4iglB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFV_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		 4igl YENC2
(Yersinia
entomophaga) 		5 / 10 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.34A 1qfvB-4iglB:
1.8		 1qfvB-4iglB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 TRP A 730
GLU A 412
ARG A 724
VAL A 442
 None
 1.12A 1rs6A-4iglA:
undetectable
1rs6B-4iglA:
undetectable		 1rs6A-4iglA:
14.88
1rs6B-4iglA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 6 VAL B 449
THR B 440
GLU B 455
LEU B 453
 None
 1.11A 1s8fB-4iglB:
undetectable		 1s8fB-4iglB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 GLU A1174
THR A1175
LEU A1197
 None
 0.70A 1v8bC-4iglA:
undetectable		 1v8bC-4iglA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 ASP B 588
TYR B 587
GLU B 292
 None
 0.84A 1vm1A-4iglB:
undetectable		 1vm1A-4iglB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A  71
GLY A  64
GLY A  66
PHE A 376
SER A  60
 None
 1.14A 1wg8A-4iglA:
undetectable		 1wg8A-4iglA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 SER B 442
VAL B  65
LEU B  60
 None
 0.66A 1yajG-4iglB:
undetectable		 1yajG-4iglB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 7 ILE A1088
ASN B  77
ILE B  79
ASP B  73
 None
 1.00A 1yc5A-4iglA:
undetectable		 1yc5A-4iglA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 GLY A 158
PRO A 188
ALA A 183
ILE A 191
 None
 0.94A 2aofA-4iglA:
undetectable		 2aofA-4iglA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 GLY A 204
PHE A1146
ASP A1142
TYR A1143
 None
 1.16A 2aouB-4iglA:
undetectable		 2aouB-4iglA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 ILE A 655
LEU A 657
ILE A 642
ILE A 624
ALA A 622
 None
 1.06A 2gj5A-4iglA:
undetectable		 2gj5A-4iglA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 5 ILE A1088
ASN B  77
ILE B  79
ASP B  73
 None
 0.93A 2h4jA-4iglA:
undetectable		 2h4jA-4iglA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 SER A  80
PRO A  99
SER A 193
LEU A  55
 None
 0.83A 2hdnE-4iglA:
undetectable
2hdnF-4iglA:
undetectable
2hdnH-4iglA:
undetectable		 2hdnE-4iglA:
3.86
2hdnF-4iglA:
12.74
2hdnH-4iglA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 SER A 193
LEU A  55
SER A  80
PRO A  99
 None
 0.86A 2hdnF-4iglA:
undetectable
2hdnG-4iglA:
undetectable
2hdnH-4iglA:
undetectable		 2hdnF-4iglA:
12.74
2hdnG-4iglA:
3.86
2hdnH-4iglA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 4 ASP A 799
ASP A 762
ASP A 797
GLY A1414
 GOL  A1502 (-3.4A)
None
None
None
 1.44A 2igtC-4iglA:
undetectable		 2igtC-4iglA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 4igl YENB
(Yersinia
entomophaga) 		5 / 11 VAL A 330
ASN A 259
THR A 261
PHE A1146
ARG A  49
 None
 1.25A 2ij7A-4iglA:
undetectable		 2ij7A-4iglA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 LEU B 371
LEU B 421
MET B 422
 None
 0.87A 2itzA-4iglB:
undetectable		 2itzA-4iglB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 ILE A 307
ASN A 309
ALA A 185
SER A 231
ASP A 296
 None
 1.38A 2iyfB-4iglA:
undetectable		 2iyfB-4iglA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 ILE A 278
VAL A1297
LEU A1292
ARG A 358
ALA A 356
 None
 1.37A 2jj8C-4iglA:
undetectable		 2jj8C-4iglA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4igl YENB
YENC2
(Yersinia
entomophaga) 		4 / 6 PHE A1097
GLN B  82
ASN B  88
LEU B 671
 None
 1.26A 2nyrA-4iglA:
undetectable		 2nyrA-4iglA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ASP A 978
THR A1469
PRO A1470
 None
 0.63A 2q64B-4iglA:
undetectable		 2q64B-4iglA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ASP A 978
THR A1469
PRO A1470
 None
 0.57A 2qakB-4iglA:
undetectable		 2qakB-4iglA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 555
PRO A 556
LEU A 515
 None
 0.38A 2qd5B-4iglA:
undetectable		 2qd5B-4iglA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 VAL A 252
ASP A 254
GLU A 198
 None
 0.74A 2qeuA-4iglA:
undetectable		 2qeuA-4iglA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 VAL A 252
ASP A 254
GLU A 198
 None
 0.74A 2qeuC-4iglA:
undetectable		 2qeuC-4iglA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 SER A1196
TYR A1206
HIS A1205
 None
 0.41A 2r2vD-4iglA:
undetectable		 2r2vD-4iglA:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 PRO A1449
GLY A 889
TYR A 900
 GOL  A1502 ( 3.6A)
None
None
 0.55A 2vouA-4iglA:
undetectable		 2vouA-4iglA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 PRO A1449
GLY A 889
TYR A 900
 GOL  A1502 ( 3.6A)
None
None
 0.48A 2vouB-4iglA:
undetectable		 2vouB-4iglA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 PRO A1449
GLY A 889
TYR A 900
 GOL  A1502 ( 3.6A)
None
None
 0.49A 2vouC-4iglA:
undetectable		 2vouC-4iglA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 GLN A 945
ARG A 930
ILE A 963
SER A1049
 None
 1.12A 2xytE-4iglA:
undetectable		 2xytE-4iglA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 GLN A 945
ARG A 930
ILE A 963
SER A1049
 None
 1.10A 2xytH-4iglA:
undetectable		 2xytH-4iglA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 8 TYR B 613
TYR B 413
GLN B 388
ILE B 439
 None
 1.13A 2xz5B-4iglB:
undetectable
2xz5E-4iglB:
undetectable		 2xz5B-4iglB:
16.62
2xz5E-4iglB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 7 GLN B 388
ILE B 439
TYR B 613
TYR B 413
 None
 1.13A 2xz5D-4iglB:
undetectable
2xz5E-4iglB:
undetectable		 2xz5D-4iglB:
16.62
2xz5E-4iglB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)		 4igl YENB
(Yersinia
entomophaga) 		5 / 10 ASP A 699
GLN A 434
ASN A 440
GLY A 437
PRO A 393
 None
 1.45A 2y6rA-4iglA:
0.0		 2y6rA-4iglA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 SER A 779
ARG A 788
PRO A 824
GLY A 822
 None
 1.32A 2y7pA-4iglA:
undetectable		 2y7pA-4iglA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 ILE A1245
PHE A1357
GLN A1366
ARG A1379
GLU A1264
 None
 1.44A 2zi9A-4iglA:
0.0		 2zi9A-4iglA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 679
TRP A 706
TYR A 723
 None
 0.95A 3aicA-4iglA:
undetectable		 3aicA-4iglA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 679
TRP A 706
TYR A 723
 None
 0.94A 3aicB-4iglA:
undetectable		 3aicB-4iglA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 679
TRP A 706
TYR A 723
 None
 0.91A 3aicE-4iglA:
undetectable		 3aicE-4iglA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 679
TRP A 706
TYR A 723
 None
 0.92A 3aicF-4iglA:
undetectable		 3aicF-4iglA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 679
TRP A 706
TYR A 723
 None
 0.94A 3aicG-4iglA:
undetectable		 3aicG-4iglA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LEU A 679
TRP A 706
TYR A 723
 None
 0.89A 3aicH-4iglA:
undetectable		 3aicH-4iglA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 TRP A 730
GLU A 412
ARG A 724
VAL A 442
 None
 1.10A 3b3pA-4iglA:
undetectable
3b3pB-4iglA:
undetectable		 3b3pA-4iglA:
14.94
3b3pB-4iglA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 LEU A 657
ASP A 699
LEU A 702
TRP A 389
 None
 1.10A 3bj8C-4iglA:
undetectable
3bj8D-4iglA:
undetectable		 3bj8C-4iglA:
8.64
3bj8D-4iglA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 VAL A 268
GLN A 210
PHE A 265
ARG A 274
 None
 1.34A 3bjwE-4iglA:
undetectable		 3bjwE-4iglA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 ILE B 514
LEU B 515
LEU B 203
THR B 231
PRO B 535
 None
 1.27A 3dcjA-4iglB:
undetectable
3dcjB-4iglB:
undetectable		 3dcjA-4iglB:
15.20
3dcjB-4iglB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 10 ARG A 234
GLY A 158
PRO A 188
ALA A 183
ILE A 191
 None
 0.95A 3ekwA-4iglA:
undetectable		 3ekwA-4iglA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 ILE B 424
ASN B 364
VAL B 342
LEU B 590
THR B 591
 None
 1.38A 3em0B-4iglB:
2.4		 3em0B-4iglB:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_A_HSMA174_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 10 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.28A 3g7xA-4iglB:
0.0		 3g7xA-4iglB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G7X_B_HSMB176_1
(FEMALE-SPECIFIC
HISTAMINE-BINDING
PROTEIN 2)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 10 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.32A 3g7xB-4iglB:
1.7		 3g7xB-4iglB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 9 GLY A 716
ALA A 717
ASP A 762
GLY A1362
ILE A  21
 None
 1.07A 3gguB-4iglA:
undetectable		 3gguB-4iglA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 PRO A 705
HIS A 753
LEU A 679
ALA A 701
 None
 1.34A 3gv1A-4iglA:
undetectable
3gv1C-4iglA:
undetectable		 3gv1A-4iglA:
6.60
3gv1C-4iglA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 4igl YENB
YENC2
(Yersinia
entomophaga) 		5 / 12 LEU B  90
ALA A1096
PHE A1097
LEU A1089
ASP B  73
 None
 1.16A 3gwuA-4iglB:
undetectable		 3gwuA-4iglB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 LEU A 525
ALA A 673
ILE A 526
LEU A 621
SER A 530
 None
 1.17A 3gyqA-4iglA:
undetectable
3gyqB-4iglA:
undetectable		 3gyqA-4iglA:
11.44
3gyqB-4iglA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 11 LEU A 525
ALA A 673
ILE A 526
LEU A 621
SER A 530
 None
 1.18A 3gyqB-4iglA:
undetectable		 3gyqB-4iglA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 THR A1198
ASP A1199
ASP A1228
GLY A1230
TYR A1343
 None
 1.15A 3hiiA-4iglA:
undetectable		 3hiiA-4iglA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 THR A1198
ASP A1199
ASP A1228
GLY A1230
TYR A1343
 None
 1.20A 3hiiB-4iglA:
0.4		 3hiiB-4iglA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 LYS A 734
ILE A 407
PHE A 495
 None
 0.92A 3j7zS-4iglA:
undetectable
3j7za-4iglA:
undetectable		 3j7zS-4iglA:
5.54
3j7za-4iglA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 ASP A1426
HIS A1334
LEU A1385
LEU A1425
 None
 0.91A 3lm8B-4iglA:
undetectable
3lm8D-4iglA:
undetectable		 3lm8B-4iglA:
9.42
3lm8D-4iglA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.86A 3p97C-4iglA:
undetectable		 3p97C-4iglA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 PHE A  68
LEU A  43
PHE A 269
LEU A 343
 None
 0.95A 3t3zA-4iglA:
undetectable		 3t3zA-4iglA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 PHE A  68
LEU A  43
PHE A 269
LEU A 343
 None
 1.00A 3t3zB-4iglA:
undetectable		 3t3zB-4iglA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 5 PHE B 256
ALA B 238
THR B 189
LEU B 242
 None
 1.19A 3t3zC-4iglB:
undetectable		 3t3zC-4iglB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 PHE A  68
LEU A  43
PHE A 269
LEU A 343
 None
 0.97A 3t3zD-4iglA:
undetectable		 3t3zD-4iglA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 ASN B 420
ALA B 418
ARG B  59
 None
 0.87A 3tj7C-4iglB:
undetectable
3tj7D-4iglB:
undetectable		 3tj7C-4iglB:
14.74
3tj7D-4iglB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 ASN B 446
ALA B 418
ARG B  59
 None
 0.91A 3tj7C-4iglB:
undetectable
3tj7D-4iglB:
undetectable		 3tj7C-4iglB:
14.74
3tj7D-4iglB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 ILE A1255
PRO A1253
SER A1345
GLY A1254
 None
 1.14A 3tkdB-4iglA:
undetectable		 3tkdB-4iglA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 ILE A1255
PRO A1253
SER A1345
GLY A1254
 None
 1.16A 3tkdA-4iglA:
undetectable		 3tkdA-4iglA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 8 TYR B 507
THR B 489
TYR B 651
LEU B 492
 None
 1.21A 3wipG-4iglB:
undetectable
3wipH-4iglB:
undetectable		 3wipG-4iglB:
15.16
3wipH-4iglB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 8 LEU B 492
TYR B 507
THR B 489
TYR B 651
 None
 1.13A 3wipF-4iglB:
undetectable
3wipJ-4iglB:
undetectable		 3wipF-4iglB:
15.16
3wipJ-4iglB:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 10 ASP A 732
ASN A 440
ARG A 724
GLY A 436
GLN A 434
 None
 1.37A 4af0B-4iglA:
undetectable		 4af0B-4iglA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 HIS A 753
TYR A  59
GLY A  71
LEU A 754
HIS A 755
 None
 1.18A 4blvB-4iglA:
undetectable		 4blvB-4iglA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.88A 4ctjC-4iglA:
undetectable		 4ctjC-4iglA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ARG A 788
TRP A 780
GLY A 782
 None
 1.01A 4e7cA-4iglA:
undetectable		 4e7cA-4iglA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4igl YENB
YENC2
(Yersinia
entomophaga) 		4 / 7 PHE A1097
ALA A1113
THR B  95
LEU A1089
 None
 0.92A 4ejgA-4iglA:
undetectable		 4ejgA-4iglA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 8 GLU B 292
GLN B 288
GLY B 287
SER B 284
 None
 0.90A 4f93B-4iglB:
undetectable		 4f93B-4iglB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ASP A 115
ARG A 135
ASP A 110
 None
 0.86A 4fp9D-4iglA:
undetectable		 4fp9D-4iglA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 8 PHE A1220
TYR A1231
THR A1340
THR B 189
 None
 1.14A 4l4dA-4iglA:
undetectable		 4l4dA-4iglA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 8 PHE A1220
TYR A1231
THR A1340
THR B 189
 None
 1.13A 4l4eA-4iglA:
undetectable		 4l4eA-4iglA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 8 PHE A1220
TYR A1231
THR A1340
THR B 189
 None
 1.14A 4l4fA-4iglA:
undetectable		 4l4fA-4iglA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 TRP B 212
GLN B 141
THR B 150
 None
 1.00A 4m2xA-4iglB:
undetectable		 4m2xA-4iglB:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 4 ILE B  25
VAL A1473
VAL B  14
ARG B  23
 None
 1.20A 4m6tA-4iglB:
undetectable		 4m6tA-4iglB:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4igl YENB
(Yersinia
entomophaga) 		5 / 11 PRO A 528
LEU A 671
LEU A 640
ILE A 642
LEU A 657
 None
 1.08A 4odrA-4iglA:
undetectable
4odrB-4iglA:
undetectable		 4odrA-4iglA:
5.88
4odrB-4iglA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 ASN A 645
ILE A 633
ILE A 632
VAL A 619
 None
 0.99A 4olmA-4iglA:
undetectable		 4olmA-4iglA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 ASP B 114
ARG B 447
ARG B 444
 None
 0.59A 4x5iA-4iglB:
undetectable		 4x5iA-4iglB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		3 / 3 ASP A1480
ARG B 310
ARG B 683
 K  A1505 (-2.7A)
None
None
 0.94A 4x5iA-4iglA:
undetectable		 4x5iA-4iglA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4igl YENB
YENC2
(Yersinia
entomophaga) 		4 / 7 LEU B  90
THR B 121
THR A1105
LEU A1109
 None
 0.88A 4z91F-4iglB:
undetectable
4z91G-4iglB:
undetectable
4z91H-4iglB:
undetectable
4z91I-4iglB:
undetectable
4z91J-4iglB:
undetectable		 4z91F-4iglB:
18.98
4z91G-4iglB:
18.98
4z91H-4iglB:
18.98
4z91I-4iglB:
18.98
4z91J-4iglB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 4 TYR A1343
GLY B 190
SER B 187
LEU B 188
 None
 1.25A 5bphC-4iglA:
undetectable		 5bphC-4iglA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 6 TYR A1343
GLY B 190
SER B 187
LEU B 188
 None
 1.22A 5bphD-4iglA:
undetectable		 5bphD-4iglA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ASN A 712
ALA A1305
ARG A1309
 None
 0.75A 5cvtB-4iglA:
undetectable		 5cvtB-4iglA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 TYR A 378
LEU A 708
GLY A 626
ILE A 681
GLY A  71
 None
 0.99A 5d4uC-4iglA:
undetectable		 5d4uC-4iglA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 TYR A 378
LEU A 708
GLY A 626
ILE A 681
GLY A  71
 None
 0.99A 5d4uD-4iglA:
undetectable		 5d4uD-4iglA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 ASP A1426
TRP A1377
VAL A1386
ALA A1394
 None
 1.30A 5dl9A-4iglA:
undetectable		 5dl9A-4iglA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.88A 5e9qC-4iglA:
undetectable		 5e9qC-4iglA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 ASP B 114
ARG B 447
ARG B 444
 None
 0.91A 5eajB-4iglB:
undetectable		 5eajB-4iglB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		3 / 3 ASP B 257
ARG B 253
ARG A1342
 None
 0.92A 5eajB-4iglB:
undetectable		 5eajB-4iglB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.88A 5eifC-4iglA:
undetectable		 5eifC-4iglA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.90A 5ekxB-4iglA:
undetectable		 5ekxB-4iglA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 ASP B 391
LEU B 487
LEU B 660
LEU B 479
THR B 489
 None
 1.18A 5hnwB-4iglB:
undetectable		 5hnwB-4iglB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 ASP B 391
LEU B 487
LEU B 660
LEU B 479
THR B 489
 None
 1.19A 5hnyB-4iglB:
undetectable		 5hnyB-4iglB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.90A 5ikmA-4iglA:
undetectable		 5ikmA-4iglA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 VAL A 685
TYR A 404
GLN A 394
HIS A 695
 None
 1.22A 5kkzA-4iglA:
undetectable
5kkzG-4iglA:
undetectable		 5kkzA-4iglA:
15.65
5kkzG-4iglA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 6 TYR B 611
ARG B 411
GLN B 387
HIS B 426
 None
 1.27A 5kkzA-4iglB:
undetectable
5kkzG-4iglB:
undetectable		 5kkzA-4iglB:
19.74
5kkzG-4iglB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 HIS A 695
VAL A 685
TYR A 404
GLN A 394
 None
 1.25A 5kkzC-4iglA:
undetectable
5kkzE-4iglA:
undetectable		 5kkzC-4iglA:
8.58
5kkzE-4iglA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 VAL A 685
TYR A 404
GLN A 394
HIS A 695
 None
 1.23A 5kkzK-4iglA:
undetectable
5kkzQ-4iglA:
undetectable		 5kkzK-4iglA:
15.65
5kkzQ-4iglA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 HIS A 695
VAL A 685
TYR A 404
GLN A 394
 None
 1.27A 5kkzM-4iglA:
undetectable
5kkzO-4iglA:
undetectable		 5kkzM-4iglA:
8.58
5kkzO-4iglA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.90A 5kqsA-4iglA:
undetectable		 5kqsA-4iglA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 5 TYR B 435
SER B 427
ALA B 428
THR B 407
 None
 1.24A 5n0tA-4iglB:
undetectable		 5n0tA-4iglB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 TYR A1206
SER A1218
TRP A1221
 None
 0.88A 5n8jB-4iglA:
0.3		 5n8jB-4iglA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 TYR A1206
SER A1218
TRP A1221
 None
 0.86A 5n8jA-4iglA:
0.4		 5n8jA-4iglA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 TYR A1206
SER A1218
TRP A1221
 None
 0.90A 5n8jD-4iglA:
undetectable		 5n8jD-4iglA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 GLY A 626
GLY A 628
VAL A 587
ASP A 631
ILE A 632
 None
None
None
K  A1503 (-2.5A)
None
 0.92A 5njvC-4iglA:
undetectable		 5njvC-4iglA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 8 ASP A1480
THR A1481
THR B   9
TYR B 372
 K  A1505 (-2.7A)
None
K  A1505 (-3.7A)
None
 1.24A 5ov9B-4iglA:
undetectable		 5ov9B-4iglA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 ASP A 377
ARG A1310
ARG A 380
LEU A  57
 None
 1.42A 5tuiB-4iglA:
undetectable		 5tuiB-4iglA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 7 VAL B 618
ARG B 411
TYR B 409
LEU B 682
 None
 1.18A 5umwB-4iglB:
undetectable
5umwE-4iglB:
undetectable		 5umwB-4iglB:
6.67
5umwE-4iglB:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 ASP A 916
SER A  80
ILE A  79
THR A 914
GLU A  95
 None
 1.14A 5vcgA-4iglA:
undetectable		 5vcgA-4iglA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 5 ARG B 411
PRO B 612
GLY B 614
TYR B 611
 None
 1.03A 5x80A-4iglB:
undetectable
5x80B-4iglB:
undetectable		 5x80A-4iglB:
14.24
5x80B-4iglB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 5 PRO B 612
GLY B 614
TYR B 611
ARG B 411
 None
 1.06A 5x80C-4iglB:
undetectable
5x80D-4iglB:
undetectable		 5x80C-4iglB:
14.24
5x80D-4iglB:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 ILE A  41
PHE A 376
LEU A 312
PRO A  67
LEU A  57
 None
 1.28A 5xxiA-4iglA:
undetectable		 5xxiA-4iglA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 PRO B 664
GLY B 666
ASN B  88
ASN B 105
ASP B  85
 None
 1.38A 5yn6A-4iglB:
undetectable		 5yn6A-4iglB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 6 GLY B 448
SER B 452
THR B 454
VAL B 460
 None
 1.17A 5ysiA-4iglB:
undetectable		 5ysiA-4iglB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4igl YENB
(Yersinia
entomophaga) 		3 / 3 ASP A 240
PHE A 284
ARG A 321
 None
 0.99A 5yw0A-4iglA:
undetectable		 5yw0A-4iglA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 6 GLU B 638
ARG B 513
ALA B 531
LYS B 516
 None
 1.10A 6an0A-4iglB:
undetectable		 6an0A-4iglB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 8 LEU B 534
TYR B 229
GLU B 227
TRP B 539
 None
 1.23A 6c71B-4iglB:
undetectable		 6c71B-4iglB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4igl YENB
(Yersinia
entomophaga) 		4 / 8 LEU A1306
GLU A 763
MET A1269
LEU A 374
 None
 1.25A 6cbzA-4iglA:
undetectable		 6cbzA-4iglA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 4igl YENC2
(Yersinia
entomophaga) 		4 / 6 HIS B 426
TYR B 435
TYR B 611
GLN B 388
 None
 1.37A 6d8pA-4iglB:
0.0		 6d8pA-4iglB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		5 / 10 SER A  75
LEU A 343
LEU A  43
PRO A  67
SER A  58
 None
 1.35A 6dlzB-4iglA:
undetectable
6dlzC-4iglA:
undetectable		 6dlzB-4iglA:
4.21
6dlzC-4iglA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		5 / 11 PRO A  67
SER A  58
SER A  75
LEU A 343
LEU A  43
 None
 1.35A 6dlzA-4iglA:
undetectable
6dlzD-4iglA:
undetectable		 6dlzA-4iglA:
4.21
6dlzD-4iglA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		5 / 10 SER A  75
LEU A 343
LEU A  43
PRO A  67
SER A  58
 None
 1.37A 6dm1B-4iglA:
undetectable
6dm1C-4iglA:
undetectable		 6dm1B-4iglA:
4.21
6dm1C-4iglA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4igl YENB
(Yersinia
entomophaga) 		5 / 11 PRO A  67
SER A  58
SER A  75
LEU A 343
LEU A  43
 None
 1.35A 6dm1A-4iglA:
undetectable
6dm1D-4iglA:
undetectable		 6dm1A-4iglA:
4.21
6dm1D-4iglA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 ASP A 625
GLY A 573
SER A 627
GLY A 628
 K  A1503 (-3.1A)
None
K  A1503 (-2.8A)
None
 0.78A 6ekzA-4iglA:
undetectable		 6ekzA-4iglA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4igl YENB
(Yersinia
entomophaga) 		4 / 5 ILE A 278
GLN A 371
THR A 370
LEU A 337
 None
 1.13A 6f3mD-4iglA:
undetectable		 6f3mD-4iglA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4igl YENB
(Yersinia
entomophaga) 		4 / 6 MET A1281
GLY A1285
ALA A1290
LEU A1291
 None
 1.02A 6fosA-4iglA:
undetectable		 6fosA-4iglA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4igl YENB
(Yersinia
entomophaga) 		5 / 12 HIS A 320
ASN A 339
PHE A  45
ASN A1210
GLN A 359
 None
 1.47A 6gnfA-4iglA:
undetectable		 6gnfA-4iglA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 VAL B 677
ARG B 411
GLN B 388
PRO B 654
GLY B 657
 None
 1.16A 6gnfA-4iglB:
undetectable		 6gnfA-4iglB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4igl YENC2
(Yersinia
entomophaga) 		5 / 12 VAL B 677
ARG B 411
GLN B 388
PRO B 654
GLY B 657
 None
 1.15A 6gnfC-4iglB:
undetectable		 6gnfC-4iglB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4igl YENB
YENC2
(Yersinia
entomophaga;
Yersinia
entomophaga) 		4 / 7 GLY A1114
ASN B 128
GLU B 127
GLY B 133
 None
 0.83A 6n7fA-4iglA:
undetectable		 6n7fA-4iglA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4igl YENB
(Yersinia
entomophaga) 		4 / 7 ASP A1188
THR A1193
TYR A1187
LEU A 325
 None
 1.22A 6nmfA-4iglA:
undetectable
6nmfC-4iglA:
undetectable
6nmfP-4iglA:
undetectable		 6nmfA-4iglA:
15.55
6nmfC-4iglA:
11.42
6nmfP-4iglA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4igl YENC2
(Yersinia
entomophaga) 		3 / 3 ASP B 246
LEU B 537
ARG B 566
 None
 0.79A 7dfrA-4iglB:
undetectable		 7dfrA-4iglB:
12.37