SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ihc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 7 LEU A 391
ALA A 392
TYR A 395
GLU A 362
 None
 0.66A 1dmaA-4ihcA:
undetectable		 1dmaA-4ihcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 6 TYR A 150
ILE A 122
TYR A 374
GLY A 373
 None
 1.13A 1maaB-4ihcA:
undetectable
1maaD-4ihcA:
undetectable		 1maaB-4ihcA:
21.49
1maaD-4ihcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 7 GLY A  62
ILE A  61
ALA A  75
ILE A  71
 None
 0.75A 1n49A-4ihcA:
undetectable		 1n49A-4ihcA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 LEU A 236
VAL A 228
TYR A 199
THR A 232
 None
IOD  A 506 ( 4.1A)
None
IOD  A 506 (-3.5A)
 1.49A 1nw3A-4ihcA:
undetectable		 1nw3A-4ihcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 PHE A 348
ILE A 350
TYR A 294
ARG A 321
 None
 1.30A 1qltA-4ihcA:
undetectable		 1qltA-4ihcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 7 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.09A 1tv8A-4ihcA:
undetectable		 1tv8A-4ihcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 7 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.08A 1tv8B-4ihcA:
3.1		 1tv8B-4ihcA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 PHE A 348
ILE A 350
TYR A 294
ARG A 321
 None
 1.37A 1vaoA-4ihcA:
undetectable		 1vaoA-4ihcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 PHE A 348
ILE A 350
TYR A 294
ARG A 321
 None
 1.37A 1vaoB-4ihcA:
undetectable		 1vaoB-4ihcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 THR A 128
GLY A 130
GLY A 131
GLY A 156
ASP A 138
 None
 1.14A 1wg8A-4ihcA:
undetectable		 1wg8A-4ihcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 THR A 128
GLY A 130
GLY A 131
GLY A 156
ASP A 138
 None
 1.19A 1wg8B-4ihcA:
undetectable		 1wg8B-4ihcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 ASP A 342
PRO A 368
VAL A 377
ILE A 122
 None
 0.92A 2aoiA-4ihcA:
undetectable		 2aoiA-4ihcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 8 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.09A 2fb2A-4ihcA:
2.8		 2fb2A-4ihcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 7 THR A 322
SER A 344
VAL A 110
MET A  96
 None
 1.13A 2fb2B-4ihcA:
3.6		 2fb2B-4ihcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 PRO A 285
ILE A 257
ARG A 261
ASP A 258
 None
 0.96A 2rhmB-4ihcA:
undetectable		 2rhmB-4ihcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 9 ALA A 323
TYR A 125
TYR A 247
GLY A 349
TYR A 150
 None
 1.41A 2zm9A-4ihcA:
undetectable		 2zm9A-4ihcA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		3 / 3 SER A 272
GLU A 352
ASP A 250
 None
FMT  A 503 (-3.2A)
MG  A 501 ( 4.8A)
 0.84A 2zthA-4ihcA:
2.3		 2zthA-4ihcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		3 / 3 SER A 272
GLU A 352
ASP A 250
 None
FMT  A 503 (-3.2A)
MG  A 501 ( 4.8A)
 0.72A 3bwmA-4ihcA:
undetectable		 3bwmA-4ihcA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		3 / 3 SER A 272
GLU A 352
ASP A 250
 None
FMT  A 503 (-3.2A)
MG  A 501 ( 4.8A)
 0.75A 3bwyA-4ihcA:
undetectable		 3bwyA-4ihcA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 ALA A  76
GLN A  73
ILE A  68
VAL A  24
LEU A  60
 None
 1.08A 3dzuA-4ihcA:
undetectable		 3dzuA-4ihcA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 ILE A 305
VAL A  24
VAL A   9
LEU A  60
ILE A  71
 None
 1.14A 3gwxB-4ihcA:
undetectable		 3gwxB-4ihcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 GLY A 334
SER A 331
ASP A  95
ILE A 305
LEU A 383
 None
 1.25A 3iv6D-4ihcA:
undetectable		 3iv6D-4ihcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 8 TYR A 199
ALA A 233
ALA A 237
THR A 269
LEU A 245
 None
 1.47A 3khmA-4ihcA:
undetectable		 3khmA-4ihcA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 LEU A 311
ALA A 308
LEU A 341
ILE A 330
GLY A 334
 None
 1.05A 3q95B-4ihcA:
undetectable		 3q95B-4ihcA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 7 ILE A 385
GLY A  37
VAL A  23
SER A 331
 None
 0.88A 4a3uB-4ihcA:
5.7		 4a3uB-4ihcA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
 None
 0.94A 4ax8A-4ihcA:
2.3		 4ax8A-4ihcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
 None
 0.94A 4azvA-4ihcA:
undetectable		 4azvA-4ihcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 11 LEU A 311
ALA A 308
LEU A 341
ILE A 330
GLY A 334
 None
 1.03A 4pxmB-4ihcA:
undetectable		 4pxmB-4ihcA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 5 ILE A 330
PRO A 327
HIS A 225
TYR A 247
 None
GOL  A 502 (-4.5A)
GOL  A 502 (-4.4A)
None
 1.09A 4s0vA-4ihcA:
undetectable		 4s0vA-4ihcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		3 / 3 SER A 272
GLU A 352
ASP A 250
 None
FMT  A 503 (-3.2A)
MG  A 501 ( 4.8A)
 0.76A 4xudA-4ihcA:
undetectable		 4xudA-4ihcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		5 / 12 LEU A 311
ALA A 308
LEU A 341
ILE A 330
GLY A 334
 None
 1.02A 5gtrA-4ihcA:
undetectable		 5gtrA-4ihcA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Dickeya
paradisiaca) 		4 / 8 ASN A 338
HIS A 298
GLU A 352
ARG A 296
 None
None
FMT  A 503 (-3.2A)
FMT  A 503 (-4.1A)
 1.15A 6b94A-4ihcA:
undetectable		 6b94A-4ihcA:
11.90