SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ihq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		3 / 3 VAL A 286
VAL A 334
TRP A 301
 None
 0.78A 1bdwA-4ihqA:
undetectable
1bdwB-4ihqA:
undetectable		 1bdwA-4ihqA:
7.50
1bdwB-4ihqA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 GLY A 267
THR A 229
THR A 270
THR A 239
 ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
ADP  A 601 (-2.9A)
 0.74A 1c9sT-4ihqA:
undetectable
1c9sU-4ihqA:
undetectable		 1c9sT-4ihqA:
11.31
1c9sU-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 LEU A 390
VAL A 409
TYR A 247
LEU A 252
 None
 0.88A 1cqpA-4ihqA:
2.5
1cqpB-4ihqA:
2.6		 1cqpA-4ihqA:
16.80
1cqpB-4ihqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 12 PHE A  39
PRO A  61
PRO A  64
THR A  65
ILE A  72
 None
 1.47A 1fm4A-4ihqA:
undetectable		 1fm4A-4ihqA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 GLY A 267
THR A 229
THR A 270
THR A 239
 ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
ADP  A 601 (-2.9A)
 0.78A 1gtfL-4ihqA:
undetectable
1gtfM-4ihqA:
undetectable		 1gtfL-4ihqA:
11.31
1gtfM-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 GLY A 267
THR A 229
THR A 270
THR A 239
 ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
ADP  A 601 (-2.9A)
 0.77A 1gtfN-4ihqA:
undetectable
1gtfO-4ihqA:
undetectable		 1gtfN-4ihqA:
11.31
1gtfO-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 6 THR A 239
GLY A 267
THR A 229
THR A 270
 ADP  A 601 (-2.9A)
ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
 0.76A 1gtnD-4ihqA:
undetectable
1gtnE-4ihqA:
undetectable		 1gtnD-4ihqA:
11.31
1gtnE-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 ALA A  77
SER A  79
ILE A  80
ILE A  96
 None
 0.91A 1yc5A-4ihqA:
2.6		 1yc5A-4ihqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 11 ARG A 161
VAL A  40
ILE A 152
ILE A  44
PRO A  21
 None
 1.32A 3ganA-4ihqA:
undetectable		 3ganA-4ihqA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A  24
ILE A  23
HIS A  43
LEU A   8
TYR A   7
 None
 1.40A 3gwxB-4ihqA:
undetectable		 3gwxB-4ihqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 12 LEU A 321
PHE A 346
ILE A 337
LEU A 371
THR A 351
 None
 1.05A 3hj3A-4ihqA:
undetectable		 3hj3A-4ihqA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 ILE A 412
ALA A 389
PHE A 391
ALA A 361
 None
 0.70A 3hrdA-4ihqA:
undetectable
3hrdB-4ihqA:
undetectable		 3hrdA-4ihqA:
21.27
3hrdB-4ihqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A 109
SER A 110
ILE A  72
GLU A  68
ASP A  67
 None
 1.41A 3ko0A-4ihqA:
undetectable
3ko0B-4ihqA:
undetectable
3ko0C-4ihqA:
undetectable
3ko0D-4ihqA:
undetectable		 3ko0A-4ihqA:
11.98
3ko0B-4ihqA:
11.98
3ko0C-4ihqA:
11.98
3ko0D-4ihqA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 11 GLU A  68
ASP A  67
LEU A 109
SER A 110
ILE A  72
 None
 1.46A 3ko0E-4ihqA:
undetectable
3ko0F-4ihqA:
undetectable
3ko0G-4ihqA:
undetectable
3ko0H-4ihqA:
undetectable		 3ko0E-4ihqA:
11.98
3ko0F-4ihqA:
11.98
3ko0G-4ihqA:
11.98
3ko0H-4ihqA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 12 GLU A  68
ASP A  67
LEU A 109
SER A 110
ILE A  72
 None
 1.44A 3ko0G-4ihqA:
undetectable
3ko0H-4ihqA:
undetectable
3ko0I-4ihqA:
undetectable
3ko0J-4ihqA:
undetectable		 3ko0G-4ihqA:
11.98
3ko0H-4ihqA:
11.98
3ko0I-4ihqA:
11.98
3ko0J-4ihqA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 11 GLU A  68
ASP A  67
LEU A 109
SER A 110
ILE A  72
 None
 1.48A 3ko0K-4ihqA:
undetectable
3ko0L-4ihqA:
undetectable
3ko0M-4ihqA:
undetectable
3ko0N-4ihqA:
undetectable		 3ko0K-4ihqA:
11.98
3ko0L-4ihqA:
11.98
3ko0M-4ihqA:
11.98
3ko0N-4ihqA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 5 VAL A 378
LEU A 371
ILE A 337
ALA A 345
 None
 0.99A 3n8yB-4ihqA:
undetectable		 3n8yB-4ihqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A 405
VAL A 260
THR A 271
 None
 0.69A 3ndtA-4ihqA:
undetectable		 3ndtA-4ihqA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		3 / 3 TYR A  56
TYR A  34
GLU A  60
 None
 0.94A 3pfgA-4ihqA:
undetectable		 3pfgA-4ihqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 12 PRO A 132
VAL A  36
TYR A  34
TYR A 138
ILE A 139
 None
 1.45A 3q5pA-4ihqA:
undetectable		 3q5pA-4ihqA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 ALA A 336
GLY A 335
ARG A 338
GLU A 293
 PO4  A 603 ( 4.0A)
None
PO4  A 603 ( 3.1A)
MG  A 602 ( 4.1A)
 0.71A 3rglA-4ihqA:
undetectable		 3rglA-4ihqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 ASN A 190
GLU A 308
TYR A 208
TYR A 184
 None
 1.13A 4mj8A-4ihqA:
undetectable
4mj8C-4ihqA:
undetectable		 4mj8A-4ihqA:
16.34
4mj8C-4ihqA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 THR A 269
LEU A 272
LEU A 294
THR A 358
 MG  A 602 ( 3.0A)
None
None
MG  A 602 ( 4.8A)
 0.64A 4z90A-4ihqA:
undetectable
4z90B-4ihqA:
undetectable
4z90C-4ihqA:
undetectable
4z90D-4ihqA:
undetectable
4z90E-4ihqA:
undetectable		 4z90A-4ihqA:
21.41
4z90B-4ihqA:
21.41
4z90C-4ihqA:
21.41
4z90D-4ihqA:
21.41
4z90E-4ihqA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A 279
GLY A 255
THR A 250
ASP A 253
LEU A 477
 None
 1.04A 5e72A-4ihqA:
3.7		 5e72A-4ihqA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 THR A 239
GLY A 267
THR A 229
THR A 270
 ADP  A 601 (-2.9A)
ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
 0.77A 5eezL-4ihqA:
undetectable
5eezV-4ihqA:
undetectable		 5eezL-4ihqA:
11.31
5eezV-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 THR A 239
GLY A 267
THR A 229
THR A 270
 ADP  A 601 (-2.9A)
ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
 0.78A 5ef1L-4ihqA:
undetectable
5ef1V-4ihqA:
undetectable		 5ef1L-4ihqA:
11.31
5ef1V-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 8 THR A 239
GLY A 267
THR A 229
THR A 270
 ADP  A 601 (-2.9A)
ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
 0.77A 5ef2L-4ihqA:
undetectable
5ef2V-4ihqA:
undetectable		 5ef2L-4ihqA:
11.31
5ef2V-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		5 / 9 ILE A 142
LEU A 133
THR A 162
ARG A 161
ILE A 164
 None
 1.37A 5ifuB-4ihqA:
2.1		 5ifuB-4ihqA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 TYR A 494
ILE A 495
THR A 232
ILE A 231
 None
 0.93A 5murB-4ihqA:
undetectable		 5murB-4ihqA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 6 ASN A 273
LEU A 234
SER A 230
PHE A 237
 None
ADP  A 601 (-4.5A)
None
ADP  A 601 (-4.7A)
 1.19A 6ekuA-4ihqA:
undetectable		 6ekuA-4ihqA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 7 ILE A 176
LEU A 175
ARG A 185
LEU A 198
 None
 0.91A 6nmpA-4ihqA:
undetectable
6nmpJ-4ihqA:
undetectable		 6nmpA-4ihqA:
20.33
6nmpJ-4ihqA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ihq FLAI ATPASE
(Sulfolobus
acidocaldarius) 		4 / 5 ILE A 176
LEU A 175
ARG A 185
LEU A 198
 None
 0.92A 6nmpN-4ihqA:
undetectable
6nmpW-4ihqA:
undetectable		 6nmpN-4ihqA:
20.33
6nmpW-4ihqA:
10.33