SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ii2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 7 HIS B  -2
LEU B  56
THR B  55
THR B  22
 None
 1.02A 1am6A-4ii2B:
undetectable		 1am6A-4ii2B:
18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.93A 2fcnA-4ii2B:
13.9		 2fcnA-4ii2B:
77.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 6 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.38A 2fcnA-4ii2B:
13.9
2fcnB-4ii2B:
13.6		 2fcnA-4ii2B:
77.11
2fcnB-4ii2B:
77.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS C  75
PRO C  76
TYR C  45
PRO C  44
 None
 1.50A 2ombA-4ii2C:
undetectable
2ombB-4ii2C:
undetectable		 2ombA-4ii2C:
22.12
2ombB-4ii2C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		4 / 5 PRO C  44
TYR C 127
TYR C  74
PRO C  76
 None
 1.50A 2ombA-4ii2C:
undetectable
2ombB-4ii2C:
undetectable		 2ombA-4ii2C:
22.12
2ombB-4ii2C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		4 / 7 PRO C  44
TYR C  74
HIS C  75
PRO C  76
 None
 1.13A 2ombC-4ii2C:
undetectable
2ombD-4ii2C:
undetectable		 2ombC-4ii2C:
22.12
2ombD-4ii2C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR C  74
HIS C  75
PRO C  76
PRO C  44
 None
 1.01A 2ombC-4ii2C:
undetectable
2ombD-4ii2C:
undetectable		 2ombC-4ii2C:
22.12
2ombD-4ii2C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE C  99
LEU C  86
LEU C 103
ILE C 106
PRO C  65
 None
 1.02A 3a50B-4ii2C:
undetectable		 3a50B-4ii2C:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 12 THR C 142
VAL C 120
LEU C 119
ILE C 123
TYR C 134
 None
 1.36A 3elzC-4ii2C:
1.8		 3elzC-4ii2C:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU C 104
PHE C  56
ILE C  54
GLY C  24
ALA C  23
 None
 1.09A 3n8xB-4ii2C:
undetectable		 3n8xB-4ii2C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE C  99
LEU C  86
LEU C 103
ILE C 106
PRO C  65
 None
 0.96A 3vrmA-4ii2C:
undetectable		 3vrmA-4ii2C:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE C 106
ILE C  99
ILE C  37
ALA C  23
VAL C  67
 None
 1.06A 4h1nA-4ii2C:
undetectable		 4h1nA-4ii2C:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.79A 4w5oA-4ii2B:
undetectable		 4w5oA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.73A 4w5qA-4ii2B:
undetectable		 4w5qA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.83A 4w5tA-4ii2B:
undetectable		 4w5tA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.72A 4z4cA-4ii2B:
undetectable		 4z4cA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.75A 4z4dA-4ii2B:
undetectable		 4z4dA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.75A 4z4eA-4ii2B:
undetectable		 4z4eA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.76A 4z4gA-4ii2B:
undetectable		 4z4gA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA C  35
THR C 111
GLY C  39
THR C 142
SER C  21
 None
 1.33A 5hfjB-4ii2C:
undetectable		 5hfjB-4ii2C:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 12 ALA C  35
THR C 111
GLY C  39
THR C 142
SER C  21
 None
 1.27A 5hfjC-4ii2C:
undetectable		 5hfjC-4ii2C:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.81A 6cbdA-4ii2B:
undetectable		 6cbdA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU C 103
ILE C  54
VAL C  26
HIS C  55
LEU C  86
 None
 1.16A 6djzA-4ii2C:
undetectable		 6djzA-4ii2C:
18.34