SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 9 ASN A  59
GLU A  67
ARG A 332
ILE A  96
ALA A 104
 None
 1.34A 1aj6A-4iikA:
undetectable		 1aj6A-4iikA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 9 GLY A 194
THR A 252
SER A 172
GLY A 331
ILE A  96
 None
 1.16A 1gtfD-4iikA:
undetectable
1gtfE-4iikA:
undetectable		 1gtfD-4iikA:
17.23
1gtfE-4iikA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 9 PHE A 123
VAL A 128
LEU A 131
PHE A 169
LEU A 159
 None
None
None
None
CL  A 410 ( 4.5A)
 1.31A 1wrkA-4iikA:
undetectable
1wrkB-4iikA:
undetectable		 1wrkA-4iikA:
15.12
1wrkB-4iikA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 5 PHE A 123
LEU A 131
PHE A 169
MET A 171
 None
 1.17A 1wrkB-4iikA:
undetectable		 1wrkB-4iikA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 5 PHE A 123
LEU A 131
PHE A 169
MET A 171
 None
 1.19A 1wrlC-4iikA:
undetectable		 1wrlC-4iikA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 7 PHE A 123
LEU A 131
PHE A 169
MET A 171
 None
 1.14A 1wrlE-4iikA:
undetectable		 1wrlE-4iikA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 7 ASN A 235
GLY A 191
THR A 170
SER A 224
 None
 1.17A 2o5yH-4iikA:
undetectable
2o5yL-4iikA:
undetectable		 2o5yH-4iikA:
21.81
2o5yL-4iikA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 6 ARG A 199
THR A 240
THR A 149
ASP A 138
 None
None
None
GOL  A 417 ( 3.5A)
 1.17A 2okcB-4iikA:
undetectable		 2okcB-4iikA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 7 LEU A 139
ILE A 156
VAL A 128
LEU A 131
 None
 0.70A 3r9vA-4iikA:
undetectable
3r9vB-4iikA:
undetectable		 3r9vA-4iikA:
20.82
3r9vB-4iikA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 11 THR A 240
VAL A 242
SER A 172
LEU A 333
VAL A 249
 None
 1.18A 3tbgA-4iikA:
undetectable		 3tbgA-4iikA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 8 PHE A 265
HIS A 282
GLU A 212
ILE A 279
 None
 1.37A 4cx7A-4iikA:
undetectable
4cx7B-4iikA:
undetectable		 4cx7A-4iikA:
20.27
4cx7B-4iikA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 12 LEU A 300
VAL A 249
THR A 252
SER A  90
GLY A 111
 None
None
None
None
MG  A 401 (-4.4A)
 1.36A 4q15A-4iikA:
undetectable		 4q15A-4iikA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 10 GLY A 331
VAL A 249
GLU A 247
VAL A 330
LEU A 301
 None
 1.19A 4yb6A-4iikA:
undetectable
4yb6E-4iikA:
undetectable		 4yb6A-4iikA:
23.62
4yb6E-4iikA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 10 GLY A 331
VAL A 249
GLU A 247
VAL A 330
LEU A 301
 None
 1.19A 4yb6B-4iikA:
undetectable
4yb6C-4iikA:
undetectable		 4yb6B-4iikA:
23.62
4yb6C-4iikA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 10 LEU A 301
GLY A 331
VAL A 249
GLU A 247
VAL A 330
 None
 1.21A 4yb6B-4iikA:
undetectable
4yb6F-4iikA:
undetectable		 4yb6B-4iikA:
23.62
4yb6F-4iikA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 5 THR A 252
GLY A 194
GLU A 212
ASP A 110
 None
None
None
MG  A 401 ( 2.8A)
 1.25A 5c0oH-4iikA:
undetectable		 5c0oH-4iikA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		5 / 12 PHE A 220
ILE A 153
LEU A 131
VAL A 128
PHE A 188
 None
 1.23A 5im2A-4iikA:
undetectable		 5im2A-4iikA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 7 ASP A  92
GLY A  47
ASP A 110
ASP A 327
 None
None
MG  A 401 ( 2.8A)
None
 0.93A 5nnwD-4iikA:
undetectable		 5nnwD-4iikA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 7 ASP A  92
GLY A  47
ASP A 110
ASP A 327
 None
None
MG  A 401 ( 2.8A)
None
 0.99A 5no9D-4iikA:
undetectable		 5no9D-4iikA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD
(Legionella
pneumophila) 		4 / 7 GLY A 114
ASP A 327
HIS A  50
ASP A  89
 CL  A 412 (-4.1A)
None
None
None
 1.04A 5no9D-4iikA:
undetectable		 5no9D-4iikA:
13.87