SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iil'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 VAL A  26
GLN A 121
ILE A 164
GLY A 154
ILE A 213
 RBF  A 401 (-3.9A)
RBF  A 401 (-3.3A)
RBF  A 401 ( 4.7A)
None
RBF  A 401 (-3.7A)
 0.89A 1bx4A-4iilA:
4.9		 1bx4A-4iilA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 ILE A 303
VAL A 135
ALA A 167
GLY A 249
SER A 251
 None
 1.12A 1kiaA-4iilA:
undetectable		 1kiaA-4iilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 ILE A 303
GLY A 129
ALA A 167
GLY A 249
SER A 251
 None
 1.13A 1nbiA-4iilA:
undetectable		 1nbiA-4iilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 ILE A 303
VAL A 135
ALA A 167
GLY A 249
SER A 251
 None
 1.06A 1nbiA-4iilA:
undetectable		 1nbiA-4iilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 ILE A 303
GLY A 129
ALA A 167
GLY A 249
SER A 251
 None
 1.13A 1nbiB-4iilA:
undetectable		 1nbiB-4iilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 ILE A 303
VAL A 135
ALA A 167
GLY A 249
SER A 251
 None
 1.06A 1nbiB-4iilA:
undetectable		 1nbiB-4iilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		4 / 6 PHE A 203
TYR A 231
ARG A 141
GLY A 229
 None
 1.48A 2i30A-4iilA:
undetectable		 2i30A-4iilA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		4 / 6 ARG A  76
ARG A 100
ILE A 115
PHE A 117
 None
 1.20A 2qeiA-4iilA:
undetectable		 2qeiA-4iilA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 ALA A  67
ARG A  63
ILE A  53
ALA A  55
PHE A 101
 None
 1.18A 3axtA-4iilA:
undetectable		 3axtA-4iilA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		4 / 8 ILE A  78
GLN A  73
ALA A  67
LEU A  66
 None
 0.86A 3ozwA-4iilA:
4.0		 3ozwA-4iilA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 GLY A 220
ARG A 200
SER A 132
VAL A 135
VAL A 248
 None
 1.44A 4ffwA-4iilA:
2.5		 4ffwA-4iilA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		4 / 5 PRO A  83
ASP A 105
ILE A 164
VAL A 286
 RBF  A 401 ( 3.7A)
RBF  A 401 (-3.2A)
RBF  A 401 ( 4.7A)
None
 1.43A 4hytA-4iilA:
2.1		 4hytA-4iilA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 VAL A 207
LYS A 148
VAL A 181
LEU A 198
LEU A 202
 None
 1.18A 4i1rA-4iilA:
4.9		 4i1rA-4iilA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 VAL A 221
GLY A 154
GLY A 187
ILE A 152
ILE A 213
 None
None
None
None
RBF  A 401 (-3.7A)
 0.98A 4iv0A-4iilA:
undetectable		 4iv0A-4iilA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		4 / 7 PRO A 212
VAL A 221
ALA A 225
TYR A 240
 None
 1.09A 4lb2A-4iilA:
undetectable		 4lb2A-4iilA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 VAL A 221
GLY A 154
GLY A 187
ILE A 152
ILE A 213
 None
None
None
None
RBF  A 401 (-3.7A)
 0.99A 4mwzB-4iilA:
undetectable		 4mwzB-4iilA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		5 / 12 GLY A 245
TYR A 240
SER A 233
ALA A 225
ALA A 243
 None
 1.45A 4ymgA-4iilA:
undetectable		 4ymgA-4iilA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4iil MEMBRANE LIPOPROTEIN
TPN38(B)
(Treponema
pallidum) 		4 / 7 ARG A 100
LEU A 102
ALA A 259
GLN A  99
 None
 1.10A 6b89A-4iilA:
undetectable		 6b89A-4iilA:
15.64