SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		5 / 9 LEU A 159
ALA A 225
PHE A 151
GLY A 231
LEU A 222
 None
 1.06A 1nr6A-4iisA:
undetectable		 1nr6A-4iisA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		4 / 4 SER A 191
ILE A 190
VAL A 204
THR A 271
 None
 1.04A 1u70A-4iisA:
undetectable		 1u70A-4iisA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		4 / 6 TYR A  23
GLY A 242
PHE A 284
SER A 241
 None
 1.25A 2a3cB-4iisA:
7.9		 2a3cB-4iisA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		4 / 8 ALA A 148
GLY A 141
SER A 224
ALA A 225
 None
 0.79A 2vh3B-4iisA:
undetectable		 2vh3B-4iisA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		3 / 3 LEU A 139
GLU A  94
ILE A  95
 None
 0.57A 3czhA-4iisA:
undetectable		 3czhA-4iisA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		5 / 9 ALA A 134
ARG A  32
GLY A  54
VAL A  55
ASN A  93
 None
None
None
None
FLC  A 402 (-4.5A)
 0.99A 4a3uA-4iisA:
5.7		 4a3uA-4iisA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		4 / 7 VAL A  19
ILE A  20
LEU A  53
LEU A  51
 None
 0.64A 4l1wA-4iisA:
10.8		 4l1wA-4iisA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		4 / 6 ILE A 162
ILE A 169
SER A 171
LEU A 234
 None
 0.94A 4m51A-4iisA:
6.6		 4m51A-4iisA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		5 / 12 TYR A 259
GLY A 242
LEU A 137
PHE A 151
LEU A 219
 None
 1.29A 4ze1A-4iisA:
undetectable		 4ze1A-4iisA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'
(Hevea
brasiliensis) 		5 / 12 GLU A 297
VAL A 296
LEU A 196
ALA A 251
GLY A 185
 None
 1.23A 5syeB-4iisA:
3.9		 5syeB-4iisA:
20.79