SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 4 ALA A  40
ARG A  16
GLN A  41
GLU A  42
 None
 1.31A 1lqtB-4iivA:
5.7		 1lqtB-4iivA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 4 ALA A  40
ARG A  16
GLN A  41
GLU A  42
 None
 1.30A 1lquB-4iivA:
5.0		 1lquB-4iivA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 8 ILE A 238
SER A 237
ARG A 209
GLU A 215
 None
 0.75A 2cdqA-4iivA:
undetectable		 2cdqA-4iivA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		3 / 3 ASP A 113
ASN A 117
THR A   8
 None
 0.70A 2pymB-4iivA:
undetectable		 2pymB-4iivA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 8 TYR A 153
VAL A 144
ILE A  14
GLY A 184
 NAP  A1901 (-4.6A)
None
NAP  A1901 (-4.0A)
NAP  A1901 (-4.9A)
 0.84A 3hjoA-4iivA:
undetectable		 3hjoA-4iivA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		5 / 11 LEU A 138
ILE A 181
ALA A 213
ALA A  19
ALA A 220
 NAP  A1901 ( 4.4A)
None
None
None
None
 1.09A 3mdtB-4iivA:
undetectable		 3mdtB-4iivA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 5 SER A 140
ILE A  14
TYR A 153
GLY A 184
 NAP  A1901 ( 3.7A)
NAP  A1901 (-4.0A)
NAP  A1901 (-4.6A)
NAP  A1901 (-4.9A)
 1.01A 3uboB-4iivA:
6.8		 3uboB-4iivA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		5 / 12 SER A   2
GLY A  51
ASN A  53
ILE A  47
ALA A  46
 None
 1.18A 4dx5B-4iivA:
2.1		 4dx5B-4iivA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 7 SER A 140
GLN A 150
TYR A 153
MET A 190
 NAP  A1901 ( 3.7A)
None
NAP  A1901 (-4.6A)
NAP  A1901 (-3.7A)
 0.52A 4hxyB-4iivA:
20.2		 4hxyB-4iivA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		4 / 7 ILE A 160
THR A 164
VAL A 107
SER A  86
 None
 1.31A 4iarA-4iivA:
undetectable		 4iarA-4iivA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		3 / 3 GLN A  77
HIS A  78
ARG A  55
 None
 1.07A 4qyqA-4iivA:
undetectable		 4qyqA-4iivA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		3 / 3 GLN A  77
HIS A  78
ARG A  55
 None
 1.06A 4qyqB-4iivA:
undetectable		 4qyqB-4iivA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		5 / 12 ARG A   3
ARG A 134
GLY A 229
GLY A 132
TYR A  82
 None
 1.30A 4r29A-4iivA:
undetectable		 4r29A-4iivA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		5 / 12 ARG A   3
ARG A 134
GLY A 229
GLY A 132
TYR A  82
 None
 1.29A 4r29B-4iivA:
undetectable		 4r29B-4iivA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4iiv 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE
(Escherichia
coli) 		5 / 12 SER A   2
GLY A  51
ASN A  53
ILE A  47
ALA A  46
 None
 0.97A 4u95B-4iivA:
2.1		 4u95B-4iivA:
14.45