SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 11 VAL A 252
LEU A 263
MET A 232
ILE A 235
ALA A 328
 None
 1.07A 2zbzA-4iiwA:
undetectable		 2zbzA-4iiwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  50
GLY A  53
SER A  54
ILE A 133
LEU A 118
 None
 0.95A 3mb5A-4iiwA:
undetectable		 3mb5A-4iiwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A 183
ILE A 133
ALA A 130
THR A 148
 None
 1.03A 3mdrA-4iiwA:
undetectable		 3mdrA-4iiwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 249
ALA A 314
PHE A 253
SER A 305
ILE A 304
 None
 1.27A 3qg2A-4iiwA:
undetectable		 3qg2A-4iiwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ILE A 249
ALA A 314
PHE A 253
SER A 305
ILE A 304
 None
 1.29A 3qg2B-4iiwA:
undetectable		 3qg2B-4iiwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 249
ALA A 314
PHE A 253
SER A 305
ILE A 304
 None
 1.31A 3qgtA-4iiwA:
undetectable		 3qgtA-4iiwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 249
ALA A 314
PHE A 253
SER A 305
ILE A 304
 None
 1.28A 3qgtB-4iiwA:
undetectable		 3qgtB-4iiwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		4 / 4 LEU A 230
ILE A 129
TYR A 271
TYR A 184
 None
 1.45A 3vt7A-4iiwA:
undetectable		 3vt7A-4iiwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		4 / 7 PHE A 326
PHE A 337
PHE A 253
ALA A 250
 None
 0.93A 4ejgA-4iiwA:
undetectable		 4ejgA-4iiwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 249
ALA A 314
SER A 305
ILE A 304
PRO A 303
 None
 1.38A 4gh8B-4iiwA:
undetectable		 4gh8B-4iiwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 12 THR A 208
TYR A 184
ALA A 315
ILE A 212
PHE A 229
 None
 1.47A 4rp9A-4iiwA:
undetectable		 4rp9A-4iiwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 10 ILE A 103
ILE A  56
PHE A  77
LEU A  63
LEU A  87
 None
SO4  A 404 (-4.1A)
PGE  A 408 ( 4.7A)
None
None
 0.93A 4rz7A-4iiwA:
undetectable		 4rz7A-4iiwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		4 / 7 VAL A 226
ARG A 216
VAL A 205
THR A 208
 None
 1.03A 5e4dA-4iiwA:
undetectable
5e4dB-4iiwA:
undetectable		 5e4dA-4iiwA:
22.13
5e4dB-4iiwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		6 / 12 LEU A 179
LYS A 206
ILE A 212
ALA A 213
PHE A 229
GLY A 181
 None
 0.96A 5j2tC-4iiwA:
undetectable		 5j2tC-4iiwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  56
GLY A  53
SER A  60
THR A  85
LEU A  87
 SO4  A 404 (-4.1A)
None
None
None
None
 0.79A 5twjA-4iiwA:
undetectable		 5twjA-4iiwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4iiw LMO1499 PROTEIN
(Listeria
monocytogenes) 		5 / 9 LEU A  94
VAL A  68
VAL A  48
ILE A  59
MET A 107
 None
 1.26A 5yf9X-4iiwA:
undetectable		 5yf9X-4iiwA:
12.50