SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ij3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		4 / 4 THR C 121
PRO C 123
THR C 122
PRO C 152
 None
 1.33A 1dsdC-4ij3C:
undetectable		 1dsdC-4ij3C:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		4 / 4 THR C 122
PRO C 152
THR C 121
PRO C 123
 None
 1.28A 1dsdC-4ij3C:
undetectable		 1dsdC-4ij3C:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		4 / 4 THR C 121
PRO C 123
THR C 122
PRO C 152
 None
 1.33A 1dsdC-4ij3C:
undetectable		 1dsdC-4ij3C:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		4 / 4 THR C 122
PRO C 152
THR C 121
PRO C 123
 None
 1.28A 1dsdC-4ij3C:
undetectable		 1dsdC-4ij3C:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		4 / 6 GLY C 101
ASP C  98
GLY C  33
TYR C  32
 None
 0.87A 1eswA-4ij3C:
undetectable		 1eswA-4ij3C:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		3 / 3 GLU C 196
THR C 192
LEU C 164
 None
 0.71A 1v8bC-4ij3C:
undetectable		 1v8bC-4ij3C:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens) 		5 / 9 LEU A 150
GLU A 193
SER A 208
GLU A 155
ALA A 153
 None
 1.34A 1wrlA-4ij3A:
0.0
1wrlB-4ij3A:
0.0		 1wrlA-4ij3A:
16.52
1wrlB-4ij3A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		3 / 3 THR C 115
GLU C 153
HIS C 204
 None
 0.74A 3g1uB-4ij3C:
undetectable		 3g1uB-4ij3C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens) 		3 / 3 GLU A 186
TYR A 187
SER A 267
 None
 0.82A 4at0A-4ij3A:
undetectable		 4at0A-4ij3A:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
(Mus
musculus) 		4 / 4 SER C  19
THR C  21
PHE C  79
LYS C  81
 None
 0.38A 4m93B-4ij3C:
26.3		 4m93B-4ij3C:
86.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens) 		4 / 6 GLU A  64
TYR A  36
LEU A  44
PHE A  66
 None
 1.35A 4twdF-4ij3A:
undetectable
4twdG-4ij3A:
undetectable		 4twdF-4ij3A:
19.94
4twdG-4ij3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens) 		4 / 5 VAL A 225
VAL A 231
GLY A 230
PHE A 192
 None
 1.07A 5d4nA-4ij3A:
undetectable
5d4nC-4ij3A:
undetectable		 5d4nA-4ij3A:
21.96
5d4nC-4ij3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens) 		5 / 10 PHE A 192
ARG A 217
PRO A 170
ALA A 171
VAL A 226
 None
 1.00A 5m0oA-4ij3A:
undetectable		 5m0oA-4ij3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4ij3 SULFHYDRYL OXIDASE 1
(Homo
sapiens) 		4 / 8 PHE A 192
ARG A 217
PRO A 170
ALA A 171
 None
 0.89A 5m0oC-4ij3A:
undetectable		 5m0oC-4ij3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4ij3 HEAVY CHAIN OF FAB
FRAGMENT
SULFHYDRYL OXIDASE 1
(Homo
sapiens;
Mus
musculus) 		5 / 12 LEU C   4
GLY C 101
PHE C  27
THR C  57
GLY A 117
 None
 0.93A 5veuH-4ij3C:
undetectable		 5veuH-4ij3C:
21.86