SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ijm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ILE A  31
LEU A 207
PHE A  28
LEU A  36
ILE A 222
 None
 0.95A 1cd2A-4ijmA:
undetectable		 1cd2A-4ijmA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 9 LEU A 440
ILE A 453
PHE A 278
LEU A 411
VAL A 267
 None
 1.14A 1e7aB-4ijmA:
undetectable		 1e7aB-4ijmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 ASP A 122
PHE A  76
ARG A 166
ALA A 108
 None
 0.85A 1rqpC-4ijmA:
undetectable		 1rqpC-4ijmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 ASP A 122
PHE A  76
ARG A 166
ALA A 108
 None
 0.81A 1rqpA-4ijmA:
undetectable		 1rqpA-4ijmA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ALA A 176
GLY A  71
ILE A 134
LEU A  94
ILE A 105
 None
 1.12A 1x1aA-4ijmA:
3.1		 1x1aA-4ijmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 ASP A 122
PHE A  76
ARG A 166
ALA A 108
 None
 0.78A 2v7uA-4ijmA:
undetectable		 2v7uA-4ijmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ILE A  38
GLU A  69
PHE A  59
ARG A 140
ALA A 139
 None
 1.29A 2vppA-4ijmA:
undetectable		 2vppA-4ijmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ILE A  38
GLU A  69
PHE A  59
ARG A 140
ALA A 139
 None
 1.26A 2vppB-4ijmA:
undetectable		 2vppB-4ijmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 7 LEU A 325
GLU A 336
ILE A 346
ILE A 408
 None
 0.79A 2xkwA-4ijmA:
undetectable		 2xkwA-4ijmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 6 VAL A 205
ILE A  31
HIS A 230
LEU A 223
 None
None
ATP  A 804 (-3.3A)
None
 0.74A 3hegA-4ijmA:
undetectable		 3hegA-4ijmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 THR A  42
LEU A  36
SER A  32
HIS A 230
 None
None
None
ATP  A 804 (-3.3A)
 1.03A 3kp2A-4ijmA:
undetectable
3kp2B-4ijmA:
undetectable		 3kp2A-4ijmA:
16.84
3kp2B-4ijmA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 7 GLU A 357
HIS A 359
VAL A 387
ALA A 391
 None
 0.85A 3kp6B-4ijmA:
undetectable		 3kp6B-4ijmA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 11 ILE A 130
VAL A  72
PHE A  73
VAL A 142
ILE A 105
 None
 1.06A 3rf4A-4ijmA:
undetectable
3rf4C-4ijmA:
undetectable		 3rf4A-4ijmA:
13.48
3rf4C-4ijmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 11 ILE A 105
ILE A 130
VAL A  72
PHE A  73
VAL A 142
 None
 1.09A 3rf4A-4ijmA:
undetectable
3rf4B-4ijmA:
undetectable		 3rf4A-4ijmA:
13.48
3rf4B-4ijmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 11 ILE A 105
ILE A 130
VAL A  72
PHE A  73
VAL A 142
 None
 1.02A 3rf4B-4ijmA:
undetectable
3rf4C-4ijmA:
undetectable		 3rf4B-4ijmA:
13.48
3rf4C-4ijmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 LEU A 171
THR A 181
SER A  41
ILE A 134
ALA A 133
 None
 1.22A 3vw1D-4ijmA:
undetectable		 3vw1D-4ijmA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		3 / 3 ASN A 308
GLU A 310
ARG A 374
 None
 0.89A 3wxoA-4ijmA:
undetectable		 3wxoA-4ijmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 THR A 292
LEU A 440
VAL A 298
LEU A 297
ILE A 284
 None
 1.04A 4g1bA-4ijmA:
undetectable		 4g1bA-4ijmA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 10 THR A 295
SER A 299
ALA A 376
ALA A 316
ILE A 346
 MG  A 801 ( 2.6A)
None
None
None
None
 0.93A 4lbgA-4ijmA:
3.1		 4lbgA-4ijmA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		3 / 3 ARG A 184
GLU A 198
ARG A 208
 None
 0.86A 4mwvA-4ijmA:
undetectable		 4mwvA-4ijmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 7 PHE A 412
ILE A 377
TYR A 317
PHE A 395
 None
 1.39A 4o7gA-4ijmA:
undetectable
4o7gB-4ijmA:
undetectable		 4o7gA-4ijmA:
17.72
4o7gB-4ijmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 9 ILE A 313
PHE A 315
TYR A 402
ILE A 367
GLU A 406
 None
 1.26A 4yp2B-4ijmA:
undetectable		 4yp2B-4ijmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 4 VAL A 387
ALA A 391
ASN A 390
GLN A 394
 None
 1.46A 4zgfA-4ijmA:
undetectable		 4zgfA-4ijmA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 11 ASP A 122
PHE A 151
ILE A 144
ILE A 127
PHE A  76
 None
 0.99A 5hw8E-4ijmA:
undetectable		 5hw8E-4ijmA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 11 ASP A 122
PHE A 151
ILE A 144
ILE A 127
PHE A  76
 None
 0.95A 5hw8G-4ijmA:
undetectable		 5hw8G-4ijmA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 VAL A  74
ALA A 192
PHE A 151
VAL A 168
VAL A 150
 None
 1.24A 5tudD-4ijmA:
undetectable		 5tudD-4ijmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 GLU A 357
LEU A 207
THR A  50
GLY A  49
ILE A  25
 None
None
ATP  A 803 (-4.1A)
ATP  A 803 (-3.2A)
None
 1.31A 5tuiB-4ijmA:
undetectable		 5tuiB-4ijmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 4ijm CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 10 ASP A 435
THR A 409
THR A 400
GLY A 401
GLU A 406
 None
 1.13A 6mb9C-4ijmA:
undetectable		 6mb9C-4ijmA:
10.58