SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ijr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 174
LEU A 105
SER A 112
TRP A  69
 None
 1.10A 1i7zA-4ijrA:
undetectable		 1i7zA-4ijrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 175
LYS A 209
VAL A 208
 None
 0.86A 1l2iA-4ijrA:
undetectable		 1l2iA-4ijrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  27
LEU A 127
ASN A  29
LEU A 174
LEU A 179
 None
 1.03A 1og5A-4ijrA:
undetectable		 1og5A-4ijrA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 102
HIS A 131
GLU A 216
TYR A 240
SER A 241
 None
NDP  A 401 (-3.9A)
None
NDP  A 401 (-3.3A)
NDP  A 401 (-2.8A)
 0.50A 1s2aA-4ijrA:
39.7		 1s2aA-4ijrA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 325
PRO A 324
TYR A 161
THR A 151
 None
 1.19A 2aouB-4ijrA:
undetectable		 2aouB-4ijrA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 281
ARG A 285
SER A 286
LEU A 243
ILE A 283
 None
NDP  A 401 (-2.8A)
NDP  A 401 (-2.7A)
NDP  A 401 (-3.8A)
NDP  A 401 (-4.4A)
 1.22A 2xkwB-4ijrA:
undetectable		 2xkwB-4ijrA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 PRO A  34
ILE A  65
LEU A  38
ALA A  53
LEU A  84
 None
 1.22A 3a50A-4ijrA:
undetectable		 3a50A-4ijrA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  36
GLY A  39
GLY A  37
VAL A  54
LEU A 287
 None
NDP  A 401 (-3.4A)
None
None
NDP  A 401 (-4.3A)
 1.35A 3dh0A-4ijrA:
undetectable		 3dh0A-4ijrA:
20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  71
HIS A 131
ASN A 193
TYR A 240
PHE A 325
 NDP  A 401 (-4.7A)
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
None
 1.00A 3r43A-4ijrA:
39.2		 3r43A-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  71
TRP A 102
HIS A 131
ASN A 193
TYR A 240
 NDP  A 401 (-4.7A)
None
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
 0.40A 3r43A-4ijrA:
39.2		 3r43A-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 10 TYR A  71
HIS A 131
ASN A 193
TYR A 240
PHE A 325
 NDP  A 401 (-4.7A)
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
None
 0.96A 3r58A-4ijrA:
38.1		 3r58A-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  71
HIS A 131
ASN A 193
TYR A 240
PHE A 325
 NDP  A 401 (-4.7A)
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
None
 0.99A 3r6iA-4ijrA:
38.1		 3r6iA-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  71
TRP A 102
HIS A 131
ASN A 193
TYR A 240
 NDP  A 401 (-4.7A)
None
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
 0.46A 3r6iA-4ijrA:
38.1		 3r6iA-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 9 TYR A  71
HIS A 131
ASN A 193
TYR A 240
PHE A 325
 NDP  A 401 (-4.7A)
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
None
 0.89A 3r8gA-4ijrA:
38.1		 3r8gA-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  71
HIS A 131
ASN A 193
TYR A 240
PHE A 325
 NDP  A 401 (-4.7A)
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
None
 0.99A 3r94A-4ijrA:
38.1		 3r94A-4ijrA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 240
ASN A 193
ILE A 321
PHE A 325
 NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
NDP  A 401 ( 4.8A)
None
 1.11A 3tvxB-4ijrA:
undetectable		 3tvxB-4ijrA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		6 / 12 TYR A  71
TRP A 102
HIS A 131
ASN A 193
TYR A 240
SER A 241
 NDP  A 401 (-4.7A)
None
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
NDP  A 401 (-2.8A)
 0.46A 3ug8A-4ijrA:
38.1		 3ug8A-4ijrA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 102
HIS A 131
TRP A 132
PHE A 136
 None
NDP  A 401 (-3.9A)
NDP  A 401 ( 4.1A)
None
 1.46A 3v35A-4ijrA:
40.3		 3v35A-4ijrA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 132
TRP A 102
THR A 151
 NDP  A 401 ( 4.1A)
None
None
 1.42A 4bboB-4ijrA:
undetectable		 4bboB-4ijrA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 292
LEU A  36
GLY A  37
TYR A  24
 None
 0.77A 4iqqB-4ijrA:
undetectable		 4iqqB-4ijrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 292
LEU A  36
GLY A  37
TYR A  24
 None
 0.74A 4iqqC-4ijrA:
undetectable		 4iqqC-4ijrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 5 THR A  50
THR A  73
THR A  98
HIS A  64
 None
 1.40A 4pgfB-4ijrA:
undetectable		 4pgfB-4ijrA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  68
ILE A 321
THR A 238
VAL A 212
 None
NDP  A 401 ( 4.8A)
None
None
 0.82A 4r20A-4ijrA:
undetectable		 4r20A-4ijrA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 MET A 224
ASP A 311
PHE A 312
 None
 1.04A 4xeyB-4ijrA:
undetectable		 4xeyB-4ijrA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 9 TYR A  71
TRP A 102
HIS A 131
ASN A 193
TYR A 240
 NDP  A 401 (-4.7A)
None
NDP  A 401 (-3.9A)
NDP  A 401 (-3.3A)
NDP  A 401 (-3.3A)
 0.44A 4yvvA-4ijrA:
39.8		 4yvvA-4ijrA:
34.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  72
HIS A  44
ASP A 141
 None
 0.87A 5c0oG-4ijrA:
undetectable		 5c0oG-4ijrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  65
LEU A  95
ALA A  60
LEU A  36
SER A 286
 None
None
None
None
NDP  A 401 (-2.7A)
 0.92A 5km9B-4ijrA:
undetectable		 5km9B-4ijrA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 4 THR A 151
VAL A 153
PRO A 324
THR A 159
 None
 1.00A 5mthA-4ijrA:
undetectable
5mthH-4ijrA:
undetectable		 5mthA-4ijrA:
21.60
5mthH-4ijrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 292
LEU A  36
GLY A  37
TYR A  24
 None
 0.77A 5nooB-4ijrA:
undetectable		 5nooB-4ijrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 270
LYS A 262
LEU A 301
GLU A 305
 None
 1.30A 5weaA-4ijrA:
undetectable		 5weaA-4ijrA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 292
LEU A  36
GLY A  37
TYR A  24
 None
 0.79A 5x5qE-4ijrA:
undetectable		 5x5qE-4ijrA:
23.23