SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ikc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		4 / 4 ILE A2726
LEU A2725
VAL A2723
ALA A2753
 None
 0.99A 1mz9A-4ikcA:
undetectable		 1mz9A-4ikcA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		4 / 8 SER A2879
VAL A2850
GLY A2849
TRP A2845
 SO4  A3001 ( 2.6A)
None
None
None
 0.70A 2qd3A-4ikcA:
undetectable		 2qd3A-4ikcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		3 / 3 ASN A2710
ASN A2738
ARG A2918
 None
 0.68A 2rlcA-4ikcA:
undetectable		 2rlcA-4ikcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		3 / 3 ARG A2722
ASP A2764
ASN A2706
 None
 0.88A 2zzmA-4ikcA:
undetectable		 2zzmA-4ikcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		4 / 7 GLU A2829
VAL A2809
THR A2811
VAL A2802
 None
 0.43A 3em0B-4ikcA:
undetectable		 3em0B-4ikcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		5 / 12 VAL A2877
ALA A2753
PHE A2860
PHE A2889
GLY A2887
 None
 1.28A 4mm6A-4ikcA:
undetectable		 4mm6A-4ikcA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens) 		3 / 3 ARG A2824
ASP A2825
ARG A2838
 None
 0.49A 4wq4B-4ikcA:
undetectable		 4wq4B-4ikcA:
20.78