SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ikn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		5 / 12 THR A 294
LEU A 351
ILE A 295
VAL A 274
ASN A 300
 THR  A 294 ( 0.8A)
LEU  A 351 ( 0.6A)
ILE  A 295 ( 0.6A)
VAL  A 274 ( 0.5A)
ASN  A 300 ( 0.6A)
 1.18A 1wsvA-4iknA:
undetectable		 1wsvA-4iknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		5 / 12 THR A 294
LEU A 351
ILE A 295
VAL A 274
ASN A 300
 THR  A 294 ( 0.8A)
LEU  A 351 ( 0.6A)
ILE  A 295 ( 0.6A)
VAL  A 274 ( 0.5A)
ASN  A 300 ( 0.6A)
 1.23A 1wsvB-4iknA:
undetectable		 1wsvB-4iknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		5 / 12 MET A 314
PHE A 282
ASN A 372
THR A 418
LEU A 373
 MET  A 314 ( 0.0A)
PHE  A 282 ( 1.3A)
ASN  A 372 ( 0.6A)
THR  A 418 ( 0.8A)
LEU  A 373 ( 0.5A)
 1.19A 2bjfA-4iknA:
undetectable		 2bjfA-4iknA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 6 HIS A 313
ASN A 374
ILE A 190
GLN A 415
 HIS  A 313 ( 1.0A)
ASN  A 374 ( 0.6A)
ILE  A 190 ( 0.7A)
GLN  A 415 ( 0.6A)
 1.16A 2hkkA-4iknA:
undetectable		 2hkkA-4iknA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 8 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.90A 4kttB-4iknA:
undetectable		 4kttB-4iknA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 8 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.83A 4kttD-4iknA:
undetectable		 4kttD-4iknA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 8 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.91A 4ndnB-4iknA:
undetectable		 4ndnB-4iknA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 8 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.85A 4ndnD-4iknA:
undetectable		 4ndnD-4iknA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 6 ASN A 372
ILE A 191
ILE A 190
VAL A 198
 ASN  A 372 ( 0.6A)
ILE  A 191 ( 0.7A)
ILE  A 190 ( 0.7A)
VAL  A 198 ( 0.6A)
 0.89A 4olmA-4iknA:
undetectable		 4olmA-4iknA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		5 / 12 PHE A 222
LEU A 387
ILE A 210
ARG A 258
LEU A 392
 PHE  A 222 ( 1.3A)
LEU  A 387 ( 0.6A)
ILE  A 210 ( 0.7A)
ARG  A 258 ( 0.6A)
LEU  A 392 ( 0.5A)
 1.17A 5h8tA-4iknA:
undetectable		 5h8tA-4iknA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 8 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.87A 5t8sA-4iknA:
undetectable		 5t8sA-4iknA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		5 / 12 VAL A 183
LEU A 220
ARG A 246
PHE A 222
LEU A 387
 VAL  A 183 ( 0.6A)
LEU  A 220 ( 0.6A)
ARG  A 246 ( 0.6A)
PHE  A 222 ( 1.3A)
LEU  A 387 ( 0.6A)
 1.45A 6a7pB-4iknA:
undetectable		 6a7pB-4iknA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		4 / 7 GLU A 185
ASP A 188
ILE A 187
ILE A 272
 GLU  A 185 ( 0.6A)
ASP  A 188 ( 0.6A)
ILE  A 187 ( 0.6A)
ILE  A 272 ( 0.7A)
 0.84A 6fbnA-4iknA:
undetectable		 6fbnA-4iknA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4ikn AP-3 COMPLEX SUBUNIT
MU-1
(Rattus
norvegicus) 		3 / 3 ILE A 305
THR A 304
PRO A 297
 ILE  A 305 ( 0.6A)
THR  A 304 ( 0.8A)
PRO  A 297 ( 1.1A)
 0.65A 6ncsA-4iknA:
undetectable		 6ncsA-4iknA:
21.78