SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ikv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 PHE A 275
PRO A 271
GLN A 448
ALA A 303
SER A 302
 None
 1.12A 1fm4A-4ikvA:
undetectable		 1fm4A-4ikvA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 11 ILE A 470
GLY A 379
PHE A 382
MET A 304
ALA A 301
 None
 1.09A 1ju6A-4ikvA:
undetectable		 1ju6A-4ikvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 10 ILE A 470
GLY A 379
PHE A 382
MET A 304
ALA A 301
 None
 1.09A 1ju6C-4ikvA:
undetectable		 1ju6C-4ikvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		4 / 4 GLY A 195
SER A  38
ILE A 105
HIS A 109
 None
 1.24A 1yajJ-4ikvA:
undetectable		 1yajJ-4ikvA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 422
THR A 436
PHE A 275
 None
 0.69A 2x91A-4ikvA:
undetectable		 2x91A-4ikvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 LEU A 135
GLU A  35
GLY A 108
HIS A 109
MET A 196
 None
 1.36A 2zj0A-4ikvA:
undetectable		 2zj0A-4ikvA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 LEU A 135
GLU A  35
GLY A 108
HIS A 109
MET A 196
 None
 1.35A 3ce6A-4ikvA:
undetectable		 3ce6A-4ikvA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 LEU A 135
GLU A  35
GLY A 108
HIS A 109
MET A 196
 None
 1.34A 3ce6C-4ikvA:
undetectable		 3ce6C-4ikvA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 PHE A 377
CYH A 415
PHE A 353
 OLA  A 610 ( 4.2A)
OLA  A 609 ( 4.4A)
None
 0.96A 3cr5X-4ikvA:
undetectable		 3cr5X-4ikvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 PHE A 185
MET A 181
GLY A 188
LEU A 112
ALA A 336
 None
 1.05A 3i5uA-4ikvA:
undetectable		 3i5uA-4ikvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 9 ALA A 317
GLY A 312
LEU A 402
ASN A 342
ILE A 385
 None
 1.43A 3wdmA-4ikvA:
undetectable		 3wdmA-4ikvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 GLY A 101
ALA A  97
ASN A 138
ILE A 105
ILE A 128
 None
 1.08A 4aztA-4ikvA:
undetectable		 4aztA-4ikvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 ALA A 449
LEU A  76
PHE A 259
MET A 125
PHE A 122
 None
 1.12A 4eckA-4ikvA:
undetectable		 4eckA-4ikvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.95A 4k8cA-4ikvA:
undetectable		 4k8cA-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.96A 4kahA-4ikvA:
undetectable		 4kahA-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.96A 4kahB-4ikvA:
undetectable		 4kahB-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.95A 4kanA-4ikvA:
undetectable		 4kanA-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.96A 4kanB-4ikvA:
undetectable		 4kanB-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.96A 4kbeA-4ikvA:
undetectable		 4kbeA-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.97A 4lbgA-4ikvA:
undetectable		 4lbgA-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 SER A 405
TYR A 406
PRO A 388
 None
 0.96A 4lbgB-4ikvA:
undetectable		 4lbgB-4ikvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 VAL A 263
ALA A  75
MET A  79
LEU A 442
PHE A 299
 None
 1.28A 4qdcA-4ikvA:
undetectable		 4qdcA-4ikvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 11 TYR A  73
GLY A 190
VAL A 176
SER A  38
GLY A  41
 None
OLA  A 607 ( 4.1A)
None
None
None
 1.14A 4xnxA-4ikvA:
2.3		 4xnxA-4ikvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 9 LEU A 375
GLY A 478
LEU A 481
LEU A 298
ALA A 301
 None
 1.12A 5dqfA-4ikvA:
undetectable		 5dqfA-4ikvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 ASN A 138
SER A 141
SER A 140
 None
 0.73A 5gsnA-4ikvA:
undetectable		 5gsnA-4ikvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 PHE A 382
GLY A 379
PHE A 305
GLY A 412
LEU A 414
 None
 0.97A 5i73A-4ikvA:
1.4		 5i73A-4ikvA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 TYR A 406
TYR A  48
GLN A 339
 None
 0.91A 5jsdA-4ikvA:
undetectable
5jsdB-4ikvA:
undetectable		 5jsdA-4ikvA:
23.75
5jsdB-4ikvA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		3 / 3 TYR A 406
TYR A  48
GLN A 339
 None
 0.91A 5jsdB-4ikvA:
undetectable
5jsdC-4ikvA:
undetectable		 5jsdB-4ikvA:
23.75
5jsdC-4ikvA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		4 / 4 LEU A 326
ASP A 327
GLN A 325
VAL A 410
 None
 1.50A 6bzoF-4ikvA:
2.4		 6bzoF-4ikvA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GS4_A_F9EA601_0
(DIPEPTIDE AND
TRIPEPTIDE PERMEASE
A)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 10 TYR A  40
LYS A 136
ASN A 166
ASN A 342
PRO A 343
 None
 0.93A 6gs4A-4ikvA:
39.6		 6gs4A-4ikvA:
31.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		6 / 10 TYR A  40
ASN A 166
ALA A 169
GLN A 309
ASN A 342
PRO A 343
 None
 0.49A 6gz9A-4ikvA:
52.2		 6gz9A-4ikvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		6 / 10 TYR A  40
TYR A 162
ALA A 169
GLN A 309
ASN A 342
PRO A 343
 None
 0.69A 6gz9A-4ikvA:
52.2		 6gz9A-4ikvA:
14.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		4 / 6 ASN A 166
PRO A 343
ILE A 346
GLU A 413
 None
 0.37A 6h7uA-4ikvA:
49.0		 6h7uA-4ikvA:
49.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		4 / 6 ASN A 342
PRO A 343
ILE A 346
GLU A 413
 None
 0.73A 6h7uA-4ikvA:
49.0		 6h7uA-4ikvA:
49.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		7 / 8 TYR A  40
ASN A 166
GLN A 309
ASN A 342
PRO A 343
ILE A 346
GLU A 413
 None
 0.37A 6hzpA-4ikvA:
52.8		 6hzpA-4ikvA:
49.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		4 / 7 GLY A  84
LEU A  87
GLY A 102
ASN A 138
 None
 0.79A 6nm4A-4ikvA:
undetectable		 6nm4A-4ikvA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)
(Geobacillus
kaustophilus) 		5 / 12 ILE A 470
GLY A 379
PHE A 382
MET A 304
ALA A 301
 None
 1.04A 6r2eE-4ikvA:
undetectable		 6r2eE-4ikvA:
20.23