SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4il2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 12 GLY A  43
ALA A  99
GLY A 304
ILE A 305
ILE A  77
 None
 0.84A 1hshA-4il2A:
undetectable		 1hshA-4il2A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		4 / 6 THR A  46
ASP A  44
PRO A 332
VAL A 363
 None
 1.11A 2hdnI-4il2A:
undetectable
2hdnJ-4il2A:
undetectable
2hdnL-4il2A:
undetectable		 2hdnI-4il2A:
7.27
2hdnJ-4il2A:
21.92
2hdnL-4il2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		4 / 6 VAL A 363
THR A  46
ASP A  44
PRO A 332
 None
 1.18A 2hdnJ-4il2A:
undetectable
2hdnK-4il2A:
undetectable
2hdnL-4il2A:
undetectable		 2hdnJ-4il2A:
21.92
2hdnK-4il2A:
7.27
2hdnL-4il2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 12 GLY A 326
ALA A 156
ASP A 223
THR A 298
GLU A 275
 None
None
MG  A 501 (-2.4A)
None
MG  A 501 (-2.6A)
 1.21A 2vdvE-4il2A:
undetectable		 2vdvE-4il2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 11 GLY A 326
ALA A 156
ASP A 223
THR A 298
GLU A 275
 None
None
MG  A 501 (-2.4A)
None
MG  A 501 (-2.6A)
 1.21A 2vdvF-4il2A:
undetectable		 2vdvF-4il2A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 VAL A 404
TRP A 194
TRP A 413
 None
 1.21A 2xdcA-4il2A:
undetectable
2xdcB-4il2A:
undetectable		 2xdcA-4il2A:
2.75
2xdcB-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 TRP A 413
VAL A 404
TRP A 194
 None
 1.20A 2xdcA-4il2A:
undetectable
2xdcB-4il2A:
undetectable		 2xdcA-4il2A:
2.75
2xdcB-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 VAL A 404
TRP A 194
TRP A 413
 None
 1.29A 2xdcC-4il2A:
undetectable
2xdcD-4il2A:
undetectable		 2xdcC-4il2A:
2.75
2xdcD-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 VAL A 404
TRP A 194
TRP A 413
 None
 1.21A 2y5mA-4il2A:
undetectable
2y5mB-4il2A:
undetectable		 2y5mA-4il2A:
2.75
2y5mB-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 VAL A 404
TRP A 194
TRP A 413
 None
 1.20A 2y6nA-4il2A:
undetectable
2y6nB-4il2A:
undetectable		 2y6nA-4il2A:
2.75
2y6nB-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 TRP A 413
VAL A 404
TRP A 194
 None
 1.19A 2y6nA-4il2A:
undetectable
2y6nB-4il2A:
undetectable		 2y6nA-4il2A:
2.75
2y6nB-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		4 / 5 GLN A 150
PHE A 154
LEU A 221
PHE A 246
 None
 1.29A 3ablC-4il2A:
undetectable
3ablJ-4il2A:
undetectable		 3ablC-4il2A:
19.59
3ablJ-4il2A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 PRO A 346
PHE A 341
ALA A 312
 None
 0.61A 3itaD-4il2A:
undetectable		 3itaD-4il2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 12 ALA A  45
GLY A  43
MET A 102
PHE A  28
HIS A 301
 None
 1.40A 3pfgA-4il2A:
undetectable		 3pfgA-4il2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 11 GLY A  43
ALA A  99
GLY A 303
GLY A 304
ILE A 305
 None
 0.89A 3ufnA-4il2A:
undetectable		 3ufnA-4il2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 12 GLY A 382
GLY A 384
GLU A 379
ALA A 112
LEU A 119
 None
 1.07A 3vywA-4il2A:
undetectable		 3vywA-4il2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 VAL A 404
TRP A 194
TRP A 413
 None
 1.22A 3zq8A-4il2A:
undetectable
3zq8B-4il2A:
undetectable		 3zq8A-4il2A:
2.75
3zq8B-4il2A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		3 / 3 TYR A 199
ARG A 227
HIS A 225
 None
None
MG  A 501 ( 4.8A)
 1.26A 4fubA-4il2A:
undetectable		 4fubA-4il2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		4 / 7 HIS A 225
ASP A 223
VAL A 276
GLU A 275
 MG  A 501 ( 4.8A)
MG  A 501 (-2.4A)
None
MG  A 501 (-2.6A)
 0.99A 4hvrA-4il2A:
undetectable		 4hvrA-4il2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 9 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.22A 5lg3B-4il2A:
undetectable		 5lg3B-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 9 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.24A 5lg3C-4il2A:
0.5		 5lg3C-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 9 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.19A 5lg3D-4il2A:
undetectable		 5lg3D-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 10 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.23A 5lg3F-4il2A:
undetectable		 5lg3F-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 10 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.21A 5lg3G-4il2A:
undetectable		 5lg3G-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		5 / 10 ILE A 287
PHE A 314
THR A 297
ASP A 282
ILE A 311
 None
 1.22A 5lg3H-4il2A:
undetectable		 5lg3H-4il2A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		4 / 7 HIS A 225
ASP A 145
THR A 135
LEU A 143
 MG  A 501 ( 4.8A)
None
None
None
 1.15A 5x1bA-4il2A:
undetectable
5x1bC-4il2A:
undetectable
5x1bP-4il2A:
undetectable		 5x1bA-4il2A:
20.83
5x1bC-4il2A:
19.59
5x1bP-4il2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4il2 STARVATION SENSING
PROTEIN RSPA
(Escherichia
coli) 		4 / 7 HIS A 225
ASP A 145
THR A 135
LEU A 143
 MG  A 501 ( 4.8A)
None
None
None
 1.13A 6nmfA-4il2A:
undetectable
6nmfC-4il2A:
undetectable
6nmfP-4il2A:
undetectable		 6nmfA-4il2A:
20.83
6nmfC-4il2A:
19.59
6nmfP-4il2A:
19.59