SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4il3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 4 ASP A 394
HIS A 297
ARG A 440
GLU A 390
 None
ZN  A 501 (-3.2A)
None
ZN  A 501 (-1.7A)
 0.85A 1lqtA-4il3A:
undetectable		 1lqtA-4il3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1426_0
(FPRA)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 4 ASP A 394
HIS A 297
ARG A 440
GLU A 390
 None
ZN  A 501 (-3.2A)
None
ZN  A 501 (-1.7A)
 0.79A 1lquA-4il3A:
0.0		 1lquA-4il3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 5 ILE A 291
LEU A 413
ALA A 409
GLU A 290
 None
 1.32A 1xvaA-4il3A:
undetectable
1xvaB-4il3A:
undetectable		 1xvaA-4il3A:
22.58
1xvaB-4il3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 4 LEU A 426
SER A 429
TYR A 430
LEU A  33
 None
 0.91A 1xz1A-4il3A:
3.0		 1xz1A-4il3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 4 LEU A 426
SER A 429
TYR A 430
LEU A  33
 None
 0.90A 1xz3A-4il3A:
3.0		 1xz3A-4il3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 5 TYR A  32
SER A  31
TYR A  35
ARG A  36
 None
 0.79A 2kqeA-4il3A:
undetectable		 2kqeA-4il3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 5 ASP A 193
TRP A 196
PHE A 190
VAL A 200
 None
 1.17A 2zbuB-4il3A:
2.0		 2zbuB-4il3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4il3 STE24P
(Saccharomyces
mikatae) 		3 / 3 ARG A  67
VAL A 423
THR A 420
 None
 0.85A 3cyxA-4il3A:
undetectable		 3cyxA-4il3A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 6 LEU A 426
SER A 429
TYR A 430
LEU A  33
 None
 0.88A 3rd0A-4il3A:
3.0		 3rd0A-4il3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4il3 STE24P
(Saccharomyces
mikatae) 		3 / 3 GLN A  26
PHE A  29
TYR A 430
 None
 1.00A 3ucjA-4il3A:
undetectable		 3ucjA-4il3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4il3 STE24P
(Saccharomyces
mikatae) 		4 / 7 TYR A 432
PRO A 435
THR A 436
SER A 428
 None
 1.29A 5b6iA-4il3A:
undetectable		 5b6iA-4il3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4il3 STE24P
(Saccharomyces
mikatae) 		3 / 3 VAL A 423
TYR A 427
GLU A 439
 None
 0.84A 5zmqD-4il3A:
undetectable
5zmqE-4il3A:
undetectable		 5zmqD-4il3A:
17.57
5zmqE-4il3A:
7.74