SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4il5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 ARG A  10
ASP A  59
ASN A  88
 None
LLP  A  58 ( 4.7A)
LLP  A  58 (-3.9A)
 0.77A 1nbhA-4il5A:
3.0		 1nbhA-4il5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 ARG A  10
ASP A  59
ASN A  88
 None
LLP  A  58 ( 4.7A)
LLP  A  58 (-3.9A)
 0.78A 1nbhD-4il5A:
2.4		 1nbhD-4il5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 10 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.02A 1t7iA-4il5A:
undetectable		 1t7iA-4il5A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ILE A 106
ALA A 125
ALA A  96
LEU A  93
LEU A  75
 None
 1.10A 2h79A-4il5A:
undetectable		 2h79A-4il5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 0.98A 2nnkA-4il5A:
undetectable		 2nnkA-4il5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 GLY A  87
GLN A 159
PHE A 160
PHE A 241
 ILE  A 401 (-3.5A)
ILE  A 401 (-2.4A)
ILE  A 401 (-4.9A)
None
 1.22A 2qx4A-4il5A:
undetectable
2qx4B-4il5A:
undetectable		 2qx4A-4il5A:
20.06
2qx4B-4il5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 8 MET A 265
ALA A 266
GLY A 282
ILE A 285
 None
 0.66A 2zm9A-4il5A:
undetectable		 2zm9A-4il5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 GLU A 175
HIS A 170
HIS A 169
 None
 0.83A 3co4A-4il5A:
undetectable		 3co4A-4il5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.01A 3d20A-4il5A:
undetectable		 3d20A-4il5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 VAL A 191
SER A 189
ILE A 257
ALA A 287
ILE A 304
 LLP  A  58 ( 3.8A)
None
None
None
None
 1.20A 3ddyA-4il5A:
undetectable		 3ddyA-4il5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.01A 3ektA-4il5A:
undetectable		 3ektA-4il5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 10 GLY A 282
ALA A 283
GLY A 288
LEU A 289
ILE A 257
 None
 0.94A 3em3A-4il5A:
undetectable		 3em3A-4il5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.03A 3gguB-4il5A:
undetectable		 3gguB-4il5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 10 ILE A 285
SER A 280
GLY A 282
SER A 308
LEU A  29
 None
LLP  A  58 ( 2.5A)
None
LLP  A  58 ( 3.3A)
None
 1.38A 3ik6B-4il5A:
undetectable
3ik6E-4il5A:
undetectable		 3ik6B-4il5A:
22.81
3ik6E-4il5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 6 SER A 308
GLY A 233
GLU A 219
GLU A 220
 LLP  A  58 ( 3.3A)
None
None
None
 1.14A 3k9fA-4il5A:
undetectable
3k9fB-4il5A:
undetectable
3k9fD-4il5A:
undetectable		 3k9fA-4il5A:
22.91
3k9fB-4il5A:
22.91
3k9fD-4il5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 ASN A 165
ASN A 158
GLU A  83
 None
 0.84A 3kpdC-4il5A:
undetectable		 3kpdC-4il5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 ASN A 165
ASN A 158
GLU A  83
 None
 0.88A 3kpdB-4il5A:
undetectable		 3kpdB-4il5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		6 / 9 LEU A  75
GLY A  97
ALA A  96
ILE A  65
GLY A  90
ILE A 106
 None
 1.25A 3nu4B-4il5A:
undetectable		 3nu4B-4il5A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 5 GLY A 238
GLU A 217
GLY A 240
PRO A 218
 None
 1.08A 3onnA-4il5A:
2.7		 3onnA-4il5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.02A 3oxcB-4il5A:
undetectable		 3oxcB-4il5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 8 ASP A  59
GLY A  22
TYR A  14
ARG A  10
 LLP  A  58 ( 4.7A)
None
None
None
 0.92A 3s3nA-4il5A:
undetectable		 3s3nA-4il5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
ALA A  96
GLY A  90
ILE A 106
VAL A  66
 None
 0.94A 3u7sA-4il5A:
undetectable		 3u7sA-4il5A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 0.95A 3u7sA-4il5A:
undetectable		 3u7sA-4il5A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASN A  88
ILE A 106
GLY A  62
THR A  85
GLY A  97
 LLP  A  58 (-3.9A)
None
LLP  A  58 ( 3.8A)
ILE  A 401 (-4.2A)
None
 1.03A 3uq6A-4il5A:
3.1		 3uq6A-4il5A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASN A  88
ILE A 106
GLY A  62
THR A  85
GLY A  97
 LLP  A  58 (-3.9A)
None
LLP  A  58 ( 3.8A)
ILE  A 401 (-4.2A)
None
 0.99A 3vaqA-4il5A:
undetectable		 3vaqA-4il5A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASN A  88
ILE A 106
GLY A  62
THR A  85
GLY A  97
 LLP  A  58 (-3.9A)
None
LLP  A  58 ( 3.8A)
ILE  A 401 (-4.2A)
None
 1.00A 3vasA-4il5A:
3.2		 3vasA-4il5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.01A 4dqcB-4il5A:
undetectable		 4dqcB-4il5A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ASP A 273
THR A 301
ILE A 285
VAL A  32
ILE A  38
 None
 1.42A 4eb6B-4il5A:
2.3
4eb6C-4il5A:
undetectable		 4eb6B-4il5A:
22.08
4eb6C-4il5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 10 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.01A 4njtB-4il5A:
undetectable		 4njtB-4il5A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 1.03A 4q1wA-4il5A:
undetectable		 4q1wA-4il5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 9 LEU A  75
GLY A  97
ALA A  96
GLY A  90
ILE A 106
 None
 0.93A 5kr0B-4il5A:
undetectable		 5kr0B-4il5A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A 224
LYS A 205
GLU A 202
GLY A 199
GLY A 195
 None
None
None
None
LLP  A  58 ( 3.8A)
 1.15A 5l6eA-4il5A:
undetectable		 5l6eA-4il5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 8 LEU A 331
ILE A 321
TRP A 263
GLN A 260
 None
 0.99A 5ljbA-4il5A:
undetectable		 5ljbA-4il5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 THR A  24
GLU A 175
HIS A 169
 None
 0.89A 5xioA-4il5A:
undetectable		 5xioA-4il5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 THR A  24
GLU A 175
HIS A 169
 None
 0.89A 5xiqB-4il5A:
undetectable		 5xiqB-4il5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 THR A  24
GLU A 175
HIS A 169
 None
 0.91A 5xiqD-4il5A:
undetectable		 5xiqD-4il5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A  48
ILE A 275
ILE A 330
LEU A 331
ILE A 285
 None
 0.98A 5y2tB-4il5A:
undetectable		 5y2tB-4il5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 ALA A 139
GLY A 135
GLY A 132
ASN A 144
 None
 0.76A 5ybbB-4il5A:
undetectable		 5ybbB-4il5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4il5 CYSTEINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 GLY A  23
SER A 189
VAL A 187
ILE A 176
ASP A 179
 None
 1.24A 6bxmA-4il5A:
2.8		 6bxmA-4il5A:
25.39