SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ilr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 ILE A 266
GLY A 275
GLY A 273
THR A 145
VAL A 142
 None
 0.94A 1nv8A-4ilrA:
undetectable		 1nv8A-4ilrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 ILE A 266
GLY A 275
GLY A 273
THR A 145
VAL A 142
 None
 0.92A 1nv8B-4ilrA:
undetectable		 1nv8B-4ilrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 264
ILE A 119
ALA A  86
TYR A 263
LEU A 125
 None
 1.15A 2japB-4ilrA:
undetectable		 2japB-4ilrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		3 / 3 LEU A  19
PRO A  20
ARG A  64
 None
 0.60A 2qd4B-4ilrA:
undetectable		 2qd4B-4ilrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		3 / 3 LEU A  19
PRO A  20
ARG A  64
 None
 0.55A 2qd5A-4ilrA:
undetectable		 2qd5A-4ilrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 11 LEU A  81
ARG A  80
ILE A  12
PRO A  13
GLY A  78
 None
 1.09A 3bpxA-4ilrA:
undetectable
3bpxB-4ilrA:
undetectable		 3bpxA-4ilrA:
19.31
3bpxB-4ilrA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 ILE A  53
ILE A  37
SER A  39
LYS A  41
ILE A  55
 None
 1.10A 3cd2A-4ilrA:
undetectable		 3cd2A-4ilrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		4 / 5 PHE A 274
ILE A 223
GLY A 271
HIS A  57
 None
 1.28A 3r0lD-4ilrA:
undetectable		 3r0lD-4ilrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 ILE A 245
VAL A 178
LEU A 147
SER A 169
LEU A 216
 None
 1.13A 3w67C-4ilrA:
undetectable		 3w67C-4ilrA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 LEU A 125
LEU A 259
ASN A 256
LEU A 255
VAL A 139
 None
 1.40A 3zqtA-4ilrA:
undetectable		 3zqtA-4ilrA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 GLY A 271
ILE A  53
PHE A  54
ILE A  55
HIS A  57
 None
 0.99A 4ax8A-4ilrA:
undetectable		 4ax8A-4ilrA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 SER A 149
ILE A 203
ASN A 206
SER A 205
PHE A 199
 None
 1.31A 4c49C-4ilrA:
undetectable		 4c49C-4ilrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		4 / 6 GLU A 276
ILE A 277
GLU A 128
VAL A 120
 None
 0.97A 4ejwB-4ilrA:
undetectable		 4ejwB-4ilrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		4 / 8 TYR A   9
LEU A  40
VAL A  93
VAL A  97
 None
 0.98A 4em2A-4ilrA:
undetectable		 4em2A-4ilrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 12 ILE A  31
ILE A  12
LEU A  14
GLY A 101
ILE A 112
 None
 1.20A 4o1eA-4ilrA:
undetectable		 4o1eA-4ilrA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		4 / 6 PRO A  20
ILE A  75
VAL A  11
THR A 105
 None
 1.18A 4xe5A-4ilrA:
undetectable		 4xe5A-4ilrA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2
(Sulfolobus
solfataricus) 		5 / 10 SER A 116
GLY A   8
ILE A   4
ALA A  86
PHE A 243
 None
 1.40A 5zjiA-4ilrA:
undetectable
5zjiJ-4ilrA:
undetectable		 5zjiA-4ilrA:
14.80
5zjiJ-4ilrA:
11.74