SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ily'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 12 ALA A 198
ILE A 214
PHE A 211
LEU A 187
LEU A 239
 None
 1.16A 1dtlA-4ilyA:
undetectable		 1dtlA-4ilyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 6 LYS A  62
LYS A  63
ALA A  66
VAL A 179
 None
 0.68A 1hk1A-4ilyA:
undetectable		 1hk1A-4ilyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 6 PHE A 193
LYS A  62
LYS A  63
ALA A  66
 None
 0.65A 1hk2A-4ilyA:
undetectable		 1hk2A-4ilyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		3 / 3 ASN A 124
PHE A 149
VAL A 114
 None
 0.86A 1kijA-4ilyA:
undetectable		 1kijA-4ilyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 12 LEU A 133
ASP A 146
GLY A  95
HIS A 142
PHE A 149
 None
 1.39A 1v8bA-4ilyA:
undetectable		 1v8bA-4ilyA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 12 LEU A 133
ASP A 146
GLY A  95
HIS A 142
PHE A 149
 None
 1.42A 1v8bD-4ilyA:
undetectable		 1v8bD-4ilyA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 9 PHE A 162
ALA A 156
ALA A  98
GLY A  99
GLY A  85
 None
 1.35A 2v7bA-4ilyA:
undetectable		 2v7bA-4ilyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 9 PHE A 162
ALA A 156
ALA A  98
GLY A  99
GLY A  85
 None
 1.33A 2v7bB-4ilyA:
undetectable		 2v7bB-4ilyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 6 VAL A  70
ASN A  75
TYR A 196
ILE A 100
 None
 1.01A 3q5sA-4ilyA:
undetectable		 3q5sA-4ilyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 11 ARG A 120
ALA A 157
ILE A  87
GLY A  99
ILE A 100
 None
 1.14A 3spkA-4ilyA:
undetectable		 3spkA-4ilyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 9 ARG A 120
ALA A 156
ILE A  87
GLY A  99
ILE A 100
 None
 1.19A 3u7sB-4ilyA:
undetectable		 3u7sB-4ilyA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 8 PHE A 193
ASP A 197
ALA A  73
SER A  72
 None
 1.08A 4lv9A-4ilyA:
undetectable
4lv9B-4ilyA:
undetectable		 4lv9A-4ilyA:
20.27
4lv9B-4ilyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 7 PHE A 193
ASP A 197
ALA A  73
SER A  72
 None
 1.09A 4lv9A-4ilyA:
undetectable
4lv9B-4ilyA:
undetectable		 4lv9A-4ilyA:
20.27
4lv9B-4ilyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		5 / 10 ARG A 120
ALA A 156
ASP A 152
GLY A  99
ILE A 100
 None
 1.07A 4q1wB-4ilyA:
undetectable		 4q1wB-4ilyA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 4 GLY A 186
ASP A 185
ARG A 180
MET A  67
 None
 1.27A 5gwkB-4ilyA:
undetectable		 5gwkB-4ilyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 7 ILE A  65
ASP A  58
LEU A  57
GLY A  56
 None
 0.82A 5h3aB-4ilyA:
undetectable		 5h3aB-4ilyA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 6 ILE A  65
ASP A  58
LEU A  57
GLY A  56
 None
 0.96A 5x5qE-4ilyA:
undetectable		 5x5qE-4ilyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4ily CHITOSANASE
(Streptomyces
sp.
SirexAA-E) 		4 / 7 GLY A 203
PHE A 211
HIS A 202
SER A 213
 None
 0.99A 6hu9S-4ilyA:
undetectable
6hu9q-4ilyA:
undetectable		 6hu9S-4ilyA:
11.98
6hu9q-4ilyA:
21.12