SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4im4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 9 VAL A 221
LEU A 147
ILE A 214
SER A 164
LEU A 168
 None
 1.18A 1eqgA-4im4A:
undetectable		 1eqgA-4im4A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.84A 1jnoA-4im4A:
undetectable		 1jnoA-4im4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.84A 1jnoB-4im4A:
undetectable		 1jnoB-4im4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.87A 1magA-4im4A:
undetectable		 1magA-4im4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.87A 1magB-4im4A:
undetectable		 1magB-4im4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.85A 1ng8A-4im4A:
undetectable		 1ng8A-4im4A:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.84A 1ng8B-4im4A:
undetectable		 1ng8B-4im4A:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.92A 1nruA-4im4A:
undetectable		 1nruA-4im4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  76
VAL A 107
TRP A 125
 None
 0.91A 1nruB-4im4A:
undetectable		 1nruB-4im4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.31A 1nsiA-4im4A:
undetectable
1nsiB-4im4A:
undetectable		 1nsiA-4im4A:
21.28
1nsiB-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.37A 1nsiA-4im4A:
undetectable
1nsiB-4im4A:
undetectable		 1nsiA-4im4A:
21.28
1nsiB-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.27A 1nsiC-4im4A:
0.0
1nsiD-4im4A:
undetectable		 1nsiC-4im4A:
21.28
1nsiD-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.30A 1nsiC-4im4A:
0.0
1nsiD-4im4A:
undetectable		 1nsiC-4im4A:
21.28
1nsiD-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ILE A 155
ASP A 110
LEU A 147
ARG A 163
 None
 1.40A 2a7qA-4im4A:
undetectable		 2a7qA-4im4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 285
LYS A 322
PRO A 272
 None
 1.45A 2dqyB-4im4A:
0.8		 2dqyB-4im4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LEU A 137
PHE A 179
ILE A 145
ALA A 143
 None
 0.92A 2j5mA-4im4A:
undetectable		 2j5mA-4im4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_A_ETVA302_1
(DEOXYCYTIDINE KINASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  55
TYR A 142
ARG A 226
ARG A 262
PHE A 236
 None
 1.50A 2no6A-4im4A:
undetectable		 2no6A-4im4A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.35A 2nsiA-4im4A:
undetectable
2nsiB-4im4A:
undetectable		 2nsiA-4im4A:
21.28
2nsiB-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.31A 2nsiA-4im4A:
undetectable
2nsiB-4im4A:
undetectable		 2nsiA-4im4A:
21.28
2nsiB-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.30A 2nsiC-4im4A:
undetectable
2nsiD-4im4A:
undetectable		 2nsiC-4im4A:
21.28
2nsiD-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.31A 2nsiC-4im4A:
undetectable
2nsiD-4im4A:
undetectable		 2nsiC-4im4A:
21.28
2nsiD-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 238
ILE A 144
ASN A  69
PHE A 347
 None
 0.90A 2opxA-4im4A:
undetectable		 2opxA-4im4A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 213
ASP A 212
GLU A 161
 None
 0.74A 2qeuA-4im4A:
1.6		 2qeuA-4im4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 297
HIS A 334
HIS A 331
 None
 0.94A 3co4A-4im4A:
14.4		 3co4A-4im4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.34A 3e7gA-4im4A:
undetectable
3e7gB-4im4A:
undetectable		 3e7gA-4im4A:
21.74
3e7gB-4im4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.35A 3e7gA-4im4A:
undetectable
3e7gB-4im4A:
undetectable		 3e7gA-4im4A:
21.74
3e7gB-4im4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.34A 3e7gC-4im4A:
0.0
3e7gD-4im4A:
0.1		 3e7gC-4im4A:
21.74
3e7gD-4im4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.33A 3e7gC-4im4A:
0.1
3e7gD-4im4A:
0.1		 3e7gC-4im4A:
21.74
3e7gD-4im4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 273
TYR A 362
ILE A 320
 None
 0.70A 3eteA-4im4A:
undetectable
3eteB-4im4A:
undetectable		 3eteA-4im4A:
21.17
3eteB-4im4A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 352
LEU A 365
ASN A 366
LEU A  70
PRO A  85
 None
 1.10A 3q87B-4im4A:
undetectable		 3q87B-4im4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 317
TYR A 374
ILE A 377
LEU A 381
VAL A 103
 None
 1.07A 3rukA-4im4A:
undetectable		 3rukA-4im4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 SER A 271
TYR A 335
VAL A 346
THR A 295
 None
 1.03A 3tneA-4im4A:
undetectable		 3tneA-4im4A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ARG A 367
ALA A 102
GLY A 315
PRO A 106
LEU A  70
 None
 1.18A 3u7sB-4im4A:
undetectable		 3u7sB-4im4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.31A 4cx7A-4im4A:
undetectable
4cx7B-4im4A:
undetectable		 4cx7A-4im4A:
21.28
4cx7B-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.28A 4cx7C-4im4A:
undetectable
4cx7D-4im4A:
undetectable		 4cx7C-4im4A:
21.28
4cx7D-4im4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ASN A 101
MET A 141
HIS A 185
LEU A 137
 None
 1.40A 4g5jA-4im4A:
undetectable		 4g5jA-4im4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 175
TRP A 172
PHE A 188
GLU A 173
 None
 1.32A 4nosC-4im4A:
undetectable
4nosD-4im4A:
undetectable		 4nosC-4im4A:
21.40
4nosD-4im4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TRP A 172
PHE A 188
GLU A 173
ILE A 175
 None
 1.29A 4nosC-4im4A:
undetectable
4nosD-4im4A:
undetectable		 4nosC-4im4A:
21.40
4nosD-4im4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 313
ARG A 104
GLY A  67
HIS A 268
 None
 1.05A 4oltB-4im4A:
undetectable		 4oltB-4im4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 7 ILE A 301
LEU A 294
TYR A 335
ALA A 269
ILE A 267
 None
 1.03A 4y03A-4im4A:
undetectable		 4y03A-4im4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU A 294
TYR A 335
ALA A 269
ILE A 267
 None
 1.17A 4y03B-4im4A:
undetectable		 4y03B-4im4A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 9 VAL A 133
VAL A 129
ILE A 175
PHE A 188
LEU A 186
 None
 1.39A 5e4dA-4im4A:
undetectable		 5e4dA-4im4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PRO A 106
LEU A  74
GLY A 352
LEU A 365
ASN A  72
 None
 1.31A 5emlA-4im4A:
8.1		 5emlA-4im4A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLU A 123
GLY A 114
THR A 108
TRP A 109
 None
 0.89A 5flcB-4im4A:
0.7		 5flcB-4im4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLU A 123
GLY A 114
THR A 108
TRP A 109
 None
 0.90A 5flcF-4im4A:
undetectable		 5flcF-4im4A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TRP A 172
MET A 191
ASN A 218
 None
 1.36A 5uc1A-4im4A:
undetectable		 5uc1A-4im4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 188
ARG A 178
GLY A 229
ILE A 225
LEU A 187
 None
 1.19A 5ul4A-4im4A:
2.6		 5ul4A-4im4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4im4 ENDOGLUCANASE E
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 193
TRP A 203
HIS A 149
 None
 0.96A 5xipA-4im4A:
undetectable		 5xipA-4im4A:
21.47