SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4imd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		3 / 3 GLU A  73
ILE A  74
ARG A 217
 None
 0.79A 1cd2A-4imdA:
undetectable		 1cd2A-4imdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 7 LEU A 287
ILE A 219
THR A 238
MET A 193
 None
 1.14A 1kglA-4imdA:
undetectable		 1kglA-4imdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 GLU A  58
LEU A  54
ARG A 269
GLU A  23
GLU A  61
 None
 1.26A 1l7fA-4imdA:
undetectable		 1l7fA-4imdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 GLU A  58
LEU A  54
ARG A 269
GLU A  23
GLU A  61
 None
 1.25A 1l7hA-4imdA:
undetectable		 1l7hA-4imdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 6 LEU A  76
ILE A  34
VAL A  30
ALA A  70
 None
 1.06A 2j5mA-4imdA:
undetectable		 2j5mA-4imdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 4 VAL A 106
THR A 107
VAL A 144
GLY A 143
 None
 1.17A 2p2fB-4imdA:
undetectable		 2p2fB-4imdA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 PHE A 109
GLY A 143
ILE A 138
VAL A 106
PHE A  52
 None
 1.23A 2zzmA-4imdA:
undetectable		 2zzmA-4imdA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 9 LEU A 241
ILE A 245
GLY A 244
LEU A 292
SER A 293
 None
 1.13A 3ai9X-4imdA:
undetectable		 3ai9X-4imdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 6 TYR A  94
ALA A  95
LEU A  98
ALA A  66
 None
 0.76A 3b6hA-4imdA:
undetectable		 3b6hA-4imdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 6 TYR A  94
ALA A  95
LEU A  98
ALA A  66
 None
 0.66A 3b6hB-4imdA:
undetectable		 3b6hB-4imdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		3 / 3 ILE A 126
SER A 102
SER A 104
 None
 0.63A 3iltH-4imdA:
undetectable		 3iltH-4imdA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 8 ILE A  21
LEU A  26
VAL A  44
GLY A  45
 None
 0.70A 3w1wA-4imdA:
2.1		 3w1wA-4imdA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		8 / 10 ILE A 138
LEU A 141
THR A 166
GLY A 188
ASP A 190
GLU A 191
GLY A 206
SER A 207
 None
None
None
KPI  A 164 ( 4.4A)
EDO  A 303 (-3.4A)
EDO  A 303 (-3.4A)
KPI  A 164 ( 4.2A)
EDO  A 303 ( 4.0A)
 0.50A 4bwlC-4imdA:
42.2		 4bwlC-4imdA:
36.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 GLU A  58
LEU A  54
ARG A 269
GLU A  23
GLU A  61
 None
 1.25A 4mwvA-4imdA:
undetectable		 4mwvA-4imdA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 GLU A  58
LEU A  54
ARG A 269
GLU A  23
GLU A  61
 None
 1.27A 4mx0A-4imdA:
undetectable		 4mx0A-4imdA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 8 THR A 107
PRO A 108
LEU A 154
SER A 114
 None
 1.18A 4qknA-4imdA:
undetectable		 4qknA-4imdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 7 ASN A 157
LYS A 156
TYR A 180
LEU A 184
 None
None
PO4  A 301 (-4.8A)
EDO  A 302 ( 4.8A)
 1.19A 4yv5B-4imdA:
undetectable		 4yv5B-4imdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 5 LEU A 184
PHE A   8
ILE A 134
ILE A  77
 EDO  A 302 ( 4.8A)
None
None
None
 1.05A 5dzk4-4imdA:
undetectable
5dzkg-4imdA:
3.1
5dzkm-4imdA:
2.5
5dzkn-4imdA:
2.4		 5dzk4-4imdA:
16.67
5dzkg-4imdA:
23.29
5dzkm-4imdA:
23.69
5dzkn-4imdA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 8 SER A 198
ALA A 197
LEU A 228
LEU A 232
 None
None
EDO  A 304 (-4.7A)
None
 1.14A 5dzkF-4imdA:
undetectable
5dzkT-4imdA:
undetectable		 5dzkF-4imdA:
23.29
5dzkT-4imdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 ILE A 146
ASN A 145
PHE A 165
ALA A 167
SER A 104
 None
 1.18A 5igyA-4imdA:
undetectable		 5igyA-4imdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 ILE A 146
ASN A 145
PHE A 165
ALA A 167
SER A 104
 None
 1.14A 5ih0A-4imdA:
undetectable		 5ih0A-4imdA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 6 LEU A 287
ILE A 219
THR A 238
MET A 193
 None
 1.12A 5ljeA-4imdA:
undetectable		 5ljeA-4imdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 10 VAL A  44
GLY A  45
GLY A  49
ILE A  29
ALA A  66
 None
 1.08A 5vm8B-4imdA:
2.6		 5vm8B-4imdA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		5 / 12 LEU A  26
GLY A 266
ALA A 265
ILE A 254
ILE A  29
 None
 1.05A 6dh6B-4imdA:
undetectable		 6dh6B-4imdA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4imd N-ACETYLNEURAMINATE
LYASE
(Pasteurella
multocida) 		4 / 5 TYR A 121
VAL A 148
PHE A 109
GLY A  81
 None
 1.37A 6hd4A-4imdA:
undetectable		 6hd4A-4imdA:
16.61