SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4imi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		3 / 3 ALA A  28
VAL A  30
TRP A  33
 None
 0.89A 1nt6A-4imiA:
undetectable		 1nt6A-4imiA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		3 / 3 ALA A  28
VAL A  30
TRP A  33
 None
 0.89A 1nt6B-4imiA:
undetectable		 1nt6B-4imiA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 11 ALA A 151
ALA A 148
LEU A 213
SER A 156
LEU A 155
 None
 1.12A 2bxeB-4imiA:
undetectable		 2bxeB-4imiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		3 / 3 MET A 110
VAL A  93
GLU A  69
 None
 0.91A 2x9gA-4imiA:
undetectable		 2x9gA-4imiA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 11 ILE A 130
GLY A 128
TYR A 131
PHE A 180
ILE A 158
 None
 1.22A 2y7kA-4imiA:
undetectable		 2y7kA-4imiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 10 ILE A 130
GLY A 128
TYR A 131
PHE A 180
ILE A 158
 None
 1.23A 2y7kB-4imiA:
undetectable		 2y7kB-4imiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 12 ILE A 130
GLY A 128
TYR A 131
PHE A 180
ILE A 158
 None
 1.27A 2y7kC-4imiA:
undetectable		 2y7kC-4imiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		4 / 5 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.32A 3ablC-4imiA:
undetectable
3ablJ-4imiA:
undetectable		 3ablC-4imiA:
19.53
3ablJ-4imiA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 12 LEU A 276
LEU A 319
PHE A 269
HIS A 234
LEU A 251
 None
 1.38A 3adsA-4imiA:
undetectable		 3adsA-4imiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		4 / 6 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.15A 5b1bC-4imiA:
undetectable
5b1bJ-4imiA:
undetectable		 5b1bC-4imiA:
19.53
5b1bJ-4imiA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 12 ILE A 105
ALA A 151
GLY A 134
LEU A 138
VAL A  90
 None
 0.96A 5i73A-4imiA:
undetectable		 5i73A-4imiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 12 ILE A 105
ALA A 151
GLY A 134
LEU A 138
VAL A  90
 None
 0.99A 5i75A-4imiA:
undetectable		 5i75A-4imiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		3 / 3 VAL A 104
GLN A  92
CYH A  94
 None
 0.80A 5icxA-4imiA:
undetectable
5icxE-4imiA:
undetectable		 5icxA-4imiA:
22.45
5icxE-4imiA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		3 / 3 VAL A 104
GLN A  92
CYH A  94
 None
 0.83A 5icxC-4imiA:
undetectable
5icxF-4imiA:
undetectable		 5icxC-4imiA:
22.45
5icxF-4imiA:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		4 / 8 GLY A 183
ILE A 254
GLN A 295
ASP A 201
 None
 0.98A 5vlmH-4imiA:
1.7		 5vlmH-4imiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		5 / 12 VAL A 266
ASN A 302
ARG A 341
GLU A 337
PRO A 259
 None
 1.34A 6gnfC-4imiA:
undetectable		 6gnfC-4imiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4imi SYMPLEKIN
(Drosophila
melanogaster) 		4 / 6 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.33A 6nmpC-4imiA:
undetectable
6nmpJ-4imiA:
undetectable		 6nmpC-4imiA:
19.53
6nmpJ-4imiA:
11.07