SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4iml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4iml CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens) 		4 / 8 VAL L 107
ARG L  60
ALA L  18
GLU L  82
 None
 0.88A 1dmiA-4imlL:
undetectable
1dmiB-4imlL:
undetectable		 1dmiA-4imlL:
17.00
1dmiB-4imlL:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens;
Homo
sapiens) 		3 / 4 VAL L  47
TRP H 119
TRP L  34
 None
 1.42A 1gmkC-4imlL:
undetectable
1gmkD-4imlL:
undetectable		 1gmkC-4imlL:
4.41
1gmkD-4imlL:
4.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens) 		6 / 12 TYR L  35
GLN L  88
PHE L  99
VAL H  37
ALA H  97
TRP H 119
 None
 0.69A 1h8sA-4imlL:
16.6		 1h8sA-4imlL:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
(Homo
sapiens) 		4 / 7 LEU H 157
THR H 194
SER H 184
THR H 186
 None
 0.82A 1ictD-4imlH:
undetectable		 1ictD-4imlH:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4iml CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens) 		4 / 6 GLY L  23
GLN L   6
VAL L  32
ALA L  70
 None
 0.90A 1p6kA-4imlL:
undetectable		 1p6kA-4imlL:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
(Homo
sapiens) 		4 / 5 LEU H 201
GLY H 150
PRO H 142
VAL H 154
 None
 0.82A 2aojA-4imlH:
undetectable		 2aojA-4imlH:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H  95
TYR L  35
PRO L  43
TYR L  86
 None
 0.75A 2oldA-4imlH:
15.7
2oldB-4imlH:
19.0		 2oldA-4imlH:
34.29
2oldB-4imlH:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  35
PRO L  43
TYR L  86
TYR H  95
 None
 0.70A 2oldA-4imlL:
20.1
2oldB-4imlL:
19.7		 2oldA-4imlL:
43.38
2oldB-4imlL:
43.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
(Homo
sapiens) 		4 / 6 TRP H  36
MET H  81
MET H  70
LEU H  83
 None
 1.46A 2oz7A-4imlH:
undetectable		 2oz7A-4imlH:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
(Homo
sapiens) 		5 / 7 GLY H  56
PRO H  53
TYR H  33
GLY H  31
THR H  28
 None
 1.40A 3tajA-4imlH:
undetectable		 3tajA-4imlH:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4iml CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens) 		4 / 8 THR L  71
SER L  64
THR L  69
SER L  66
 None
 0.97A 5l4eA-4imlL:
undetectable
5l4eB-4imlL:
undetectable
5l4eC-4imlL:
undetectable
5l4eD-4imlL:
undetectable
5l4eE-4imlL:
undetectable		 5l4eA-4imlL:
18.87
5l4eB-4imlL:
18.87
5l4eC-4imlL:
18.87
5l4eD-4imlL:
18.87
5l4eE-4imlL:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
(Homo
sapiens) 		4 / 8 VAL H 154
GLY H 150
GLN H 146
LEU H 147
 None
 1.10A 5sxqB-4imlH:
undetectable		 5sxqB-4imlH:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens;
Homo
sapiens) 		4 / 8 HIS H  35
TYR L  97
PRO H 102
TYR L  48
 None
 1.16A 5v4vA-4imlH:
undetectable		 5v4vA-4imlH:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens;
Homo
sapiens) 		4 / 8 HIS H  35
TYR L  97
PRO H 102
TYR L  48
 None
 1.16A 5v4vB-4imlH:
undetectable		 5v4vB-4imlH:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4iml CROSSED LIGHT CHAIN
(VL-CH1)
(Homo
sapiens) 		5 / 12 VAL L 204
THR L 202
VAL L 208
GLY L 115
VAL L 149
 None
 1.10A 6drzA-4imlL:
undetectable		 6drzA-4imlL:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
(Homo
sapiens) 		4 / 6 LEU H 147
ALA H 152
SER H 143
ASN H 232
 None
 0.94A 6f88A-4imlH:
undetectable		 6f88A-4imlH:
16.75