SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4imp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		3 / 3 GLU A 220
HIS A 218
ASP A 178
 None
 0.89A 1i9gA-4impA:
7.2		 1i9gA-4impA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 6 LEU A 373
GLY A 423
LEU A 381
ILE A 164
 None
 0.95A 1yajF-4impA:
3.1		 1yajF-4impA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 10 LEU A 489
PHE A 410
ALA A 406
PRO A 280
LEU A 301
 None
 1.04A 1yi4A-4impA:
undetectable		 1yi4A-4impA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 GLY A 288
ARG A 314
ARG A 315
ALA A 365
ALA A 387
 NDP  A1501 (-3.6A)
NDP  A1501 (-3.6A)
NDP  A1501 (-3.7A)
NDP  A1501 (-3.6A)
NDP  A1501 (-3.4A)
 1.17A 2br4B-4impA:
6.9		 2br4B-4impA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 GLY A 288
ARG A 314
ASP A 342
ALA A 365
ALA A 387
 NDP  A1501 (-3.6A)
NDP  A1501 (-3.6A)
NDP  A1501 (-3.2A)
NDP  A1501 (-3.6A)
NDP  A1501 (-3.4A)
 0.89A 2br4C-4impA:
undetectable		 2br4C-4impA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 GLY A 288
ARG A 314
ASP A 342
ALA A 365
ALA A 387
 NDP  A1501 (-3.6A)
NDP  A1501 (-3.6A)
NDP  A1501 (-3.2A)
NDP  A1501 (-3.6A)
NDP  A1501 (-3.4A)
 0.76A 2br4F-4impA:
6.6		 2br4F-4impA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 5 ALA A 360
ALA A 284
GLN A 486
VAL A 297
 None
 0.86A 2nyrB-4impA:
4.5		 2nyrB-4impA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 5 LEU A 237
ARG A 239
ALA A 105
ILE A 255
 None
 0.99A 2qhfA-4impA:
undetectable		 2qhfA-4impA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 4 GLY A 209
GLY A 415
GLY A 418
GLY A 426
 None
 0.67A 3bogD-4impA:
undetectable		 3bogD-4impA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 7 ILE A 186
GLY A 224
VAL A 191
LEU A 167
 None
 0.92A 3elzA-4impA:
undetectable		 3elzA-4impA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 8 GLY A 465
PHE A 519
GLY A 472
PHE A 506
 None
 1.00A 3ko0O-4impA:
undetectable
3ko0Q-4impA:
undetectable		 3ko0O-4impA:
10.55
3ko0Q-4impA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 ALA A 298
LEU A 290
LEU A 325
GLY A 316
ILE A 286
 None
 1.22A 3lbdA-4impA:
undetectable		 3lbdA-4impA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 9 ALA A 441
ALA A 196
ASP A 197
ARG A 198
LEU A 200
 None
 1.41A 3ur0C-4impA:
undetectable		 3ur0C-4impA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 LEU A 149
LEU A 146
LEU A 144
ARG A 188
THR A 113
 None
 1.27A 4f4dA-4impA:
1.7		 4f4dA-4impA:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HXY_B_ACAB502_1
(PLM1)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 7 SER A 412
GLN A 422
TYR A 425
MET A 459
 NDP  A1501 ( 4.5A)
None
NDP  A1501 (-4.8A)
NDP  A1501 (-3.4A)
 0.55A 4hxyB-4impA:
46.7		 4hxyB-4impA:
37.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 7 LEU A 116
VAL A  89
PRO A  91
GLU A 130
 None
 1.01A 4lb2A-4impA:
0.0		 4lb2A-4impA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 ALA A 148
GLY A 189
ALA A 190
THR A 434
ILE A 164
 None
 1.04A 4nkxA-4impA:
undetectable		 4nkxA-4impA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 ALA A 148
GLY A 189
ALA A 190
THR A 434
ILE A 164
 None
 1.02A 4nkxC-4impA:
undetectable		 4nkxC-4impA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 7 ALA A 148
GLY A 189
ALA A 190
THR A 434
 None
 0.88A 4r1zB-4impA:
undetectable		 4r1zB-4impA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 ASP A 227
LEU A 228
LEU A 240
LEU A 253
ILE A 226
 None
 1.10A 4x1fA-4impA:
undetectable		 4x1fA-4impA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 ASP A 227
LEU A 228
LEU A 240
LEU A 253
ILE A 226
 None
 1.12A 4x1gA-4impA:
undetectable		 4x1gA-4impA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		3 / 3 LEU A 468
ARG A 470
ARG A 469
 None
 0.91A 4yiaB-4impA:
undetectable		 4yiaB-4impA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 11 LEU A 371
GLU A 217
LEU A 168
LEU A 373
LEU A 381
 None
 1.14A 4zn7B-4impA:
undetectable		 4zn7B-4impA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 9 ILE A 111
GLY A 241
LEU A 244
LEU A 102
LEU A 228
 None
 1.22A 5fhzB-4impA:
4.8		 5fhzB-4impA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 10 ILE A 111
GLY A 241
LEU A 244
LEU A 102
LEU A 228
 None
 1.25A 5fhzC-4impA:
5.7		 5fhzC-4impA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 5 PHE A 506
LEU A 216
GLY A 420
ILE A 473
 None
 0.91A 5ik1A-4impA:
undetectable		 5ik1A-4impA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		6 / 12 VAL A  73
LEU A 106
TRP A  85
GLY A 241
ALA A 243
LEU A 253
 None
 1.32A 5iktA-4impA:
undetectable		 5iktA-4impA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 12 SER A 145
LEU A 146
PRO A  90
VAL A 118
LEU A 149
 None
 1.35A 5jo9A-4impA:
20.9		 5jo9A-4impA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		4 / 7 PHE A 506
PHE A 510
GLY A 418
GLY A 420
 None
 0.93A 5n9xA-4impA:
4.5		 5n9xA-4impA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4
(Saccharopolyspor
a
spinosa) 		5 / 9 ALA A 428
ALA A 424
THR A 376
LEU A 373
LEU A 167
 None
 1.15A 6ay6A-4impA:
undetectable		 6ay6A-4impA:
21.75