SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4imr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 159
ILE A  23
GLY A 145
ALA A 164
GLY A 190
 NAP  A 300 (-4.4A)
NAP  A 300 (-4.0A)
None
None
NAP  A 300 (-4.9A)
 0.99A 1kiaA-4imrA:
7.3		 1kiaA-4imrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 159
ILE A  23
GLY A 145
ALA A 164
GLY A 190
 NAP  A 300 (-4.4A)
NAP  A 300 (-4.0A)
None
None
NAP  A 300 (-4.9A)
 1.00A 1kiaB-4imrA:
7.2		 1kiaB-4imrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 159
ILE A  23
GLY A 145
ALA A 164
GLY A 190
 NAP  A 300 (-4.4A)
NAP  A 300 (-4.0A)
None
None
NAP  A 300 (-4.9A)
 1.00A 1kiaC-4imrA:
7.0		 1kiaC-4imrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 159
ILE A  23
GLY A 145
ALA A 164
GLY A 190
 NAP  A 300 (-4.4A)
NAP  A 300 (-4.0A)
None
None
NAP  A 300 (-4.9A)
 1.01A 1nbhB-4imrA:
6.9		 1nbhB-4imrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 159
ILE A  23
GLY A 145
ALA A 164
GLY A 190
 NAP  A 300 (-4.4A)
NAP  A 300 (-4.0A)
None
None
NAP  A 300 (-4.9A)
 1.07A 1nbiA-4imrA:
6.9		 1nbiA-4imrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 TYR A 159
ILE A  23
GLY A 145
ALA A 164
GLY A 190
 NAP  A 300 (-4.4A)
NAP  A 300 (-4.0A)
None
None
NAP  A 300 (-4.9A)
 1.06A 1nbiB-4imrA:
6.9		 1nbiB-4imrA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		4 / 8 GLY A  60
THR A  61
ALA A  62
VAL A  16
 None
 0.87A 2a1hA-4imrA:
undetectable
2a1hB-4imrA:
undetectable		 2a1hA-4imrA:
21.12
2a1hB-4imrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 ALA A 235
LEU A 232
LEU A  31
ALA A  34
VAL A  38
 None
 0.98A 2bxgB-4imrA:
undetectable		 2bxgB-4imrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 145
ASN A  94
VAL A  92
ILE A  27
ILE A 247
 None
NAP  A 300 (-3.2A)
None
None
None
 0.94A 2q64A-4imrA:
undetectable		 2q64A-4imrA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 ALA A 235
VAL A  92
ILE A  27
GLY A  30
ILE A  90
 None
 0.99A 3em3B-4imrA:
undetectable		 3em3B-4imrA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 ALA A 235
VAL A  92
ILE A  27
GLY A  30
ILE A  90
 None
 1.04A 3oxvB-4imrA:
undetectable		 3oxvB-4imrA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 11 ALA A 235
VAL A  92
ILE A  27
GLY A  30
ILE A  90
 None
 0.96A 3oxvD-4imrA:
undetectable		 3oxvD-4imrA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 ALA A 235
VAL A  92
ILE A  27
GLY A  30
ILE A  90
 None
 0.94A 3oxwB-4imrA:
undetectable		 3oxwB-4imrA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		4 / 5 SER A 146
ILE A  23
TYR A 159
GLY A 190
 NAP  A 300 ( 3.8A)
NAP  A 300 (-4.0A)
NAP  A 300 (-4.4A)
NAP  A 300 (-4.9A)
 0.99A 3uboB-4imrA:
6.7		 3uboB-4imrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 11 ALA A 235
VAL A  92
ILE A  27
GLY A  30
ILE A  90
 None
 0.88A 4njtC-4imrA:
undetectable		 4njtC-4imrA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 9 ILE A  27
LEU A 126
VAL A  88
LEU A  15
ILE A  79
 None
 1.26A 4r38C-4imrA:
undetectable		 4r38C-4imrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 12 ILE A  27
GLY A  24
GLN A 166
ALA A 231
MET A 227
 None
 1.21A 5n0xB-4imrA:
undetectable		 5n0xB-4imrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		3 / 3 GLY A  18
ASN A  94
ARG A 196
 NAP  A 300 (-3.2A)
NAP  A 300 (-3.2A)
NAP  A 300 (-3.6A)
 0.79A 5w7bD-4imrA:
6.6		 5w7bD-4imrA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE
(Agrobacterium
fabrum) 		5 / 10 ALA A 235
VAL A  92
ILE A  27
GLY A  30
ILE A  90
 None
 0.97A 6dj2A-4imrA:
undetectable		 6dj2A-4imrA:
14.18