SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4imv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4imv RICIN
(Ricinus
communis) 		4 / 6 LEU A 107
ILE A  53
GLU A  99
ASP A 100
 None
 1.20A 1ditH-4imvA:
undetectable
1ditP-4imvA:
undetectable		 1ditH-4imvA:
21.16
1ditP-4imvA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 4imv RICIN
(Ricinus
communis) 		5 / 9 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
 None
 0.64A 1mrgA-4imvA:
18.5		 1mrgA-4imvA:
26.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4imv RICIN
(Ricinus
communis) 		4 / 8 GLY A 121
TYR A 123
ILE A 172
SER A 176
 None
 0.40A 1mrjA-4imvA:
18.9		 1mrjA-4imvA:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4imv RICIN
(Ricinus
communis) 		4 / 5 PHE A  93
LEU A  72
PHE A 117
SER A 155
 None
 1.13A 1wrlC-4imvA:
undetectable		 1wrlC-4imvA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4imv RICIN
(Ricinus
communis) 		5 / 12 ILE A 175
ALA A 178
ALA A 179
ILE A   9
PHE A  24
 None
 0.97A 2aclG-4imvA:
undetectable		 2aclG-4imvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4imv RICIN
(Ricinus
communis) 		5 / 11 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.44A 2gl0B-4imvA:
undetectable
2gl0C-4imvA:
undetectable		 2gl0B-4imvA:
19.10
2gl0C-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4imv RICIN
(Ricinus
communis) 		5 / 12 ILE A  25
THR A  17
ALA A  16
VAL A  60
PHE A  24
 None
 1.42A 2gl0A-4imvA:
undetectable
2gl0C-4imvA:
undetectable		 2gl0A-4imvA:
19.10
2gl0C-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4imv RICIN
(Ricinus
communis) 		5 / 12 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.42A 2gl0D-4imvA:
undetectable
2gl0E-4imvA:
undetectable		 2gl0D-4imvA:
19.10
2gl0E-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4imv RICIN
(Ricinus
communis) 		5 / 11 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.44A 2gl0E-4imvA:
undetectable
2gl0F-4imvA:
undetectable		 2gl0E-4imvA:
19.10
2gl0F-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4imv RICIN
(Ricinus
communis) 		5 / 11 ILE A  25
THR A  17
ALA A  16
VAL A  60
PHE A  24
 None
 1.41A 2gl0D-4imvA:
undetectable
2gl0F-4imvA:
undetectable		 2gl0D-4imvA:
19.10
2gl0F-4imvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4imv RICIN
(Ricinus
communis) 		4 / 8 PRO A 143
ALA A 147
ALA A 150
ILE A 170
 None
 0.55A 3dtuC-4imvA:
undetectable
3dtuD-4imvA:
undetectable		 3dtuC-4imvA:
16.50
3dtuD-4imvA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gB-4imvA:
undetectable		 3j6gB-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gD-4imvA:
undetectable		 3j6gD-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gF-4imvA:
undetectable		 3j6gF-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gH-4imvA:
undetectable		 3j6gH-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gJ-4imvA:
undetectable		 3j6gJ-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gL-4imvA:
undetectable		 3j6gL-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gN-4imvA:
undetectable		 3j6gN-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gP-4imvA:
undetectable		 3j6gP-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 4imv RICIN
(Ricinus
communis) 		5 / 10 VAL A  81
SER A 176
PHE A  24
THR A  12
LEU A 144
 None
 1.37A 3j6gR-4imvA:
undetectable		 3j6gR-4imvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4imv RICIN
(Ricinus
communis) 		4 / 6 ILE A  25
VAL A  28
ARG A  29
LEU A  32
 None
 0.93A 3kp6A-4imvA:
undetectable
3kp6B-4imvA:
undetectable		 3kp6A-4imvA:
20.21
3kp6B-4imvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4imv RICIN
(Ricinus
communis) 		4 / 7 TYR A  21
GLU A 177
GLN A 182
TYR A 123
 None
 1.26A 3ugrA-4imvA:
undetectable		 3ugrA-4imvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4imv RICIN
(Ricinus
communis) 		5 / 11 VAL A  81
LEU A  74
CYH A 171
LEU A 144
LEU A  62
 None
 1.16A 4p65B-4imvA:
undetectable
4p65D-4imvA:
undetectable
4p65G-4imvA:
undetectable
4p65H-4imvA:
undetectable		 4p65B-4imvA:
15.17
4p65D-4imvA:
15.17
4p65G-4imvA:
6.45
4p65H-4imvA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4imv RICIN
(Ricinus
communis) 		5 / 9 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
 None
 0.63A 4yp2B-4imvA:
20.9		 4yp2B-4imvA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4imv RICIN
(Ricinus
communis) 		5 / 9 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
 None
 0.63A 5cf9B-4imvA:
20.9		 5cf9B-4imvA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4imv RICIN
(Ricinus
communis) 		3 / 3 THR A 163
THR A 156
LEU A  68
 None
 0.69A 5m66D-4imvA:
undetectable		 5m66D-4imvA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4imv RICIN
(Ricinus
communis) 		4 / 6 VAL A  81
TYR A 123
ILE A 172
GLU A 177
 None
 0.60A 5z3jA-4imvA:
18.7		 5z3jA-4imvA:
28.83