SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4in9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 5 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.30A 1os2A-4in9A:
23.6		 1os2A-4in9A:
39.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.17A 1os2D-4in9A:
23.8		 1os2D-4in9A:
39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 6 LEU A  37
THR A  79
TYR A 196
TYR A  35
 None
 1.41A 1qvuA-4in9A:
undetectable		 1qvuA-4in9A:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.25A 1uttA-4in9A:
24.0		 1uttA-4in9A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.17A 1utzA-4in9A:
23.7		 1utzA-4in9A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.18A 1utzB-4in9A:
23.9		 1utzB-4in9A:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 1v54A-4in9A:
undetectable		 1v54A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 1v54N-4in9A:
undetectable		 1v54N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 1v55A-4in9A:
undetectable		 1v55A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 1v55N-4in9A:
undetectable		 1v55N-4in9A:
14.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 6 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.32A 1y93A-4in9A:
23.5		 1y93A-4in9A:
39.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 2dyrA-4in9A:
undetectable		 2dyrA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 2dyrN-4in9A:
undetectable		 2dyrN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 2dysA-4in9A:
undetectable		 2dysA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 2eijA-4in9A:
undetectable		 2eijA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 2eijN-4in9A:
undetectable		 2eijN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.73A 2eikA-4in9A:
undetectable		 2eikA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 2eikN-4in9A:
undetectable		 2eikN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 2eilA-4in9A:
undetectable		 2eilA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 2eilN-4in9A:
undetectable		 2eilN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 2eimA-4in9A:
undetectable		 2eimA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.73A 2eimN-4in9A:
undetectable		 2eimN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.71A 2einA-4in9A:
undetectable		 2einA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.69A 2einN-4in9A:
undetectable		 2einN-4in9A:
14.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.19A 2hu6A-4in9A:
23.8		 2hu6A-4in9A:
39.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 9 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.60A 2jihA-4in9A:
9.9		 2jihA-4in9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 8 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.58A 2jihB-4in9A:
10.1		 2jihB-4in9A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 6 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.53A 2ow9A-4in9A:
23.3		 2ow9A-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.16A 2ow9B-4in9A:
22.9		 2ow9B-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.18A 2ozrC-4in9A:
23.4		 2ozrC-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.26A 2ozrD-4in9A:
23.6		 2ozrD-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.36A 2ozrE-4in9A:
23.4		 2ozrE-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 155
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.31A 2ozrF-4in9A:
22.9		 2ozrF-4in9A:
45.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 2y69A-4in9A:
undetectable		 2y69A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 2y69N-4in9A:
undetectable		 2y69N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 2zxwN-4in9A:
undetectable		 2zxwN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 3ablA-4in9A:
undetectable		 3ablA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.79A 3ablN-4in9A:
undetectable		 3ablN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 3abmA-4in9A:
undetectable		 3abmA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 3asnN-4in9A:
undetectable		 3asnN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 3asoN-4in9A:
undetectable		 3asoN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 117
GLU A 156
HIS A 159
 ZN  A 302 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
 0.48A 3ba0A-4in9A:
21.8		 3ba0A-4in9A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 3bvdA-4in9A:
undetectable		 3bvdA-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 3dtuA-4in9A:
undetectable		 3dtuA-4in9A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 3dtuC-4in9A:
undetectable		 3dtuC-4in9A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 9 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.57A 3hy7A-4in9A:
10.4		 3hy7A-4in9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 9 LEU A 115
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.54A 3hy7B-4in9A:
10.2		 3hy7B-4in9A:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 5 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.20A 3kecA-4in9A:
23.2		 3kecA-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 155
GLU A 156
HIS A 159
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
 0.17A 3kecB-4in9A:
23.0		 3kecB-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 5 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.50A 3likA-4in9A:
23.8		 3likA-4in9A:
39.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.18A 3lilA-4in9A:
24.1		 3lilA-4in9A:
39.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 5 ILE A 114
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.80A 3ljgA-4in9A:
24.0		 3ljgA-4in9A:
39.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 5 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.50A 3lkaA-4in9A:
23.7		 3lkaA-4in9A:
40.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 3s33A-4in9A:
undetectable		 3s33A-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.73A 3s38A-4in9A:
undetectable		 3s38A-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 3s39A-4in9A:
undetectable		 3s39A-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 3s3aA-4in9A:
undetectable		 3s3aA-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.79A 3s3bA-4in9A:
undetectable		 3s3bA-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.79A 3s3cA-4in9A:
undetectable		 3s3cA-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 3s3dA-4in9A:
undetectable		 3s3dA-4in9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 6 ARG A  68
GLN A  84
TYR A  49
PHE A  71
 None
 1.44A 3tgvB-4in9A:
undetectable		 3tgvB-4in9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 6 ARG A  68
GLN A  84
TYR A  49
PHE A  71
 None
 1.42A 3tgvD-4in9A:
undetectable		 3tgvD-4in9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.73A 3wg7A-4in9A:
undetectable		 3wg7A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 3wg7N-4in9A:
undetectable		 3wg7N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 3x2qA-4in9A:
undetectable		 3x2qA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 3x2qN-4in9A:
undetectable		 3x2qN-4in9A:
14.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		5 / 6 HIS A 117
HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.53A 4a7bA-4in9A:
23.5		 4a7bA-4in9A:
45.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 5 HIS A 117
HIS A 155
GLU A 156
HIS A 159
 ZN  A 302 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
 0.28A 4a7bB-4in9A:
23.1		 4a7bB-4in9A:
45.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 7 ARG A  63
VAL A 152
PHE A 134
GLU A 138
 None
None
None
GOL  A 307 (-3.7A)
 1.38A 4jseA-4in9A:
undetectable
4jseB-4in9A:
undetectable		 4jseA-4in9A:
16.12
4jseB-4in9A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 8 TYR A  49
ILE A  51
ILE A  95
ALA A 153
 None
 0.96A 4ou1A-4in9A:
undetectable		 4ou1A-4in9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 6 SER A 141
LEU A 149
ASP A 148
LEU A  58
 None
 0.95A 4wozA-4in9A:
undetectable
4wozB-4in9A:
undetectable		 4wozA-4in9A:
18.75
4wozB-4in9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 5b1aA-4in9A:
undetectable		 5b1aA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 5b1aN-4in9A:
undetectable		 5b1aN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 5b1bA-4in9A:
undetectable		 5b1bA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 5b1bN-4in9A:
undetectable		 5b1bN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 5b3sA-4in9A:
undetectable		 5b3sA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 5iy5A-4in9A:
undetectable		 5iy5A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 5iy5N-4in9A:
undetectable		 5iy5N-4in9A:
14.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 4 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.19A 5n5jA-4in9A:
23.9		 5n5jA-4in9A:
40.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		4 / 5 HIS A 155
GLU A 156
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 ( 4.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.16A 5n5kA-4in9A:
23.4		 5n5kA-4in9A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 5w97a-4in9A:
undetectable		 5w97a-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.71A 5x19N-4in9A:
undetectable		 5x19N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.70A 5x1bA-4in9A:
undetectable		 5x1bA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.68A 5x1bN-4in9A:
undetectable		 5x1bN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.73A 5x1fA-4in9A:
undetectable		 5x1fA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.65A 5x1fN-4in9A:
undetectable		 5x1fN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 5xdqA-4in9A:
undetectable		 5xdqA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 5xdqN-4in9A:
undetectable		 5xdqN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 5xdxA-4in9A:
undetectable		 5xdxA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.73A 5xdxN-4in9A:
undetectable		 5xdxN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 5z84A-4in9A:
undetectable		 5z84A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 5z84N-4in9A:
undetectable		 5z84N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.78A 5z85A-4in9A:
undetectable		 5z85A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 5z85N-4in9A:
undetectable		 5z85N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 5z86A-4in9A:
undetectable		 5z86A-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 5z86N-4in9A:
undetectable		 5z86N-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 5zcoA-4in9A:
undetectable		 5zcoA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 5zcoN-4in9A:
undetectable		 5zcoN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 5zcpA-4in9A:
undetectable		 5zcpA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.77A 5zcpN-4in9A:
undetectable		 5zcpN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 5zcqA-4in9A:
undetectable		 5zcqA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 5zcqN-4in9A:
undetectable		 5zcqN-4in9A:
14.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 TYR A 106
HIS A 117
PHE A 119
 GOL  A 306 ( 3.6A)
ZN  A 302 (-3.2A)
GOL  A 309 ( 4.8A)
 0.61A 6esmA-4in9A:
23.3		 6esmA-4in9A:
41.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.74A 6hu9a-4in9A:
undetectable		 6hu9a-4in9A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 6hu9m-4in9A:
undetectable		 6hu9m-4in9A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 6nknN-4in9A:
undetectable		 6nknN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.71A 6nmfA-4in9A:
undetectable		 6nmfA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.72A 6nmfN-4in9A:
undetectable		 6nmfN-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.76A 6nmpA-4in9A:
undetectable		 6nmpA-4in9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4in9 KARILYSIN PROTEASE
(Tannerella
forsythia) 		3 / 3 HIS A 165
HIS A 159
HIS A 155
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.75A 6nmpN-4in9A:
undetectable		 6nmpN-4in9A:
14.17