SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ine'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.68A 1kiaA-4ineA:
15.7		 1kiaA-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.69A 1kiaD-4ineA:
undetectable		 1kiaD-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 PHE A 199
TYR A 329
PRO A 206
 None
OPE  A 502 (-4.5A)
None
 1.17A 1mcnA-4ineA:
undetectable
1mcnB-4ineA:
undetectable
1mcnP-4ineA:
undetectable		 1mcnA-4ineA:
18.46
1mcnB-4ineA:
18.46
1mcnP-4ineA:
0.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.61A 1nbhA-4ineA:
16.1		 1nbhA-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.61A 1nbhB-4ineA:
18.1		 1nbhB-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.61A 1nbhC-4ineA:
17.9		 1nbhC-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.62A 1nbhD-4ineA:
18.0		 1nbhD-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.85A 1nbiC-4ineA:
15.9		 1nbiC-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.83A 1nbiD-4ineA:
undetectable		 1nbiD-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.18A 1rs6B-4ineA:
1.1		 1rs6B-4ineA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.14A 1rs7B-4ineA:
undetectable		 1rs7B-4ineA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 11 PHE A 287
ILE A 253
GLY A 232
ILE A 304
LEU A 310
 None
None
SAH  A 501 (-3.6A)
SAH  A 501 ( 4.5A)
None
 1.07A 1z11B-4ineA:
undetectable		 1z11B-4ineA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 10 PHE A 287
ILE A 253
GLY A 232
ILE A 304
LEU A 310
 None
None
SAH  A 501 (-3.6A)
SAH  A 501 ( 4.5A)
None
 1.05A 1z11C-4ineA:
undetectable		 1z11C-4ineA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
LEU A 255
ASP A 281
ILE A 304
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-3.5A)
SAH  A 501 ( 4.5A)
 0.92A 1zq9B-4ineA:
8.1		 1zq9B-4ineA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.19A 1zzqA-4ineA:
undetectable		 1zzqA-4ineA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.20A 1zzqB-4ineA:
undetectable		 1zzqB-4ineA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.21A 1zzuA-4ineA:
undetectable		 1zzuA-4ineA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 ILE A 231
GLY A 232
GLY A 234
LEU A 255
HIS A 303
 None
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.0A)
 0.70A 2fk8A-4ineA:
26.3		 2fk8A-4ineA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
ASP A 254
ALA A 282
ARG A 298
HIS A 303
 SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.66A 2gluA-4ineA:
19.1		 2gluA-4ineA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
ASP A 254
ALA A 282
HIS A 303
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.0A)
 0.57A 2gluA-4ineA:
19.1		 2gluA-4ineA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
ALA A 282
ARG A 298
HIS A 303
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.62A 2gluB-4ineA:
18.7		 2gluB-4ineA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 TYR A 195
TYR A 418
PHE A 340
HIS A 424
 OPE  A 502 (-3.9A)
None
None
None
 1.03A 2ha4A-4ineA:
undetectable		 2ha4A-4ineA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 TYR A  13
TYR A 141
HIS A 251
SER A 278
 None
 1.23A 2vmyA-4ineA:
2.8
2vmyB-4ineA:
2.8		 2vmyA-4ineA:
23.71
2vmyB-4ineA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 5 TYR A 187
ARG A 347
TYR A 349
TYR A 329
 SAH  A 501 ( 4.1A)
OPE  A 502 (-3.9A)
OPE  A 502 (-4.7A)
OPE  A 502 (-4.5A)
 1.48A 2wb9A-4ineA:
undetectable		 2wb9A-4ineA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 SER A  10
GLU A 105
ASP A 109
 None
 0.73A 2zulA-4ineA:
13.9		 2zulA-4ineA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 SER A  10
GLU A 105
ASP A 109
 None
 0.69A 3dmhA-4ineA:
13.6		 3dmhA-4ineA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 11 GLY A 232
GLY A 234
ILE A 253
ASP A 281
ALA A 282
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-3.5A)
SAH  A 501 (-3.6A)
 0.66A 3dxyA-4ineA:
12.7		 3dxyA-4ineA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
CYH A 300
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
 0.83A 3e23A-4ineA:
19.1		 3e23A-4ineA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
ASP A 281
ALA A 282
ILE A 304
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.6A)
SAH  A 501 ( 4.5A)
 0.52A 3fuuA-4ineA:
12.5		 3fuuA-4ineA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 11 GLY A 232
GLY A 234
ASP A 281
ALA A 282
ILE A 304
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.6A)
SAH  A 501 ( 4.5A)
 0.73A 3grvA-4ineA:
9.1		 3grvA-4ineA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 7 LEU A 182
TYR A 187
VAL A 250
ILE A 253
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
None
None
 1.32A 3ik3B-4ineA:
2.3		 3ik3B-4ineA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 10 ALA A  96
LEU A  68
LEU A  59
ILE A 103
LEU A  74
 None
 1.21A 3jw5B-4ineA:
2.2		 3jw5B-4ineA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.10A 3n62A-4ineA:
undetectable		 3n62A-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.19A 3n62B-4ineA:
undetectable		 3n62B-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.10A 3n66B-4ineA:
undetectable		 3n66B-4ineA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 GLY A 234
ASP A 254
ASP A 281
 SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 0.32A 3ou7C-4ineA:
16.7		 3ou7C-4ineA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 TYR A 187
GLY A 234
LEU A 255
SER A 256
MET A 259
ASP A 281
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.67A 3pfgA-4ineA:
13.0		 3pfgA-4ineA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
SER A 256
MET A 259
PHE A 199
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
None
 1.33A 3pfgA-4ineA:
13.0		 3pfgA-4ineA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 5 LEU A 157
ARG A 114
ILE A 262
ARG A 266
 None
 1.25A 3ticA-4ineA:
undetectable		 3ticA-4ineA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 7 SER A  10
TYR A  39
ILE A  69
THR A  47
 None
 0.96A 3tneB-4ineA:
undetectable		 3tneB-4ineA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 11 THR A 280
VAL A 162
SER A 278
ASP A 144
ILE A 160
 None
 1.19A 3uawA-4ineA:
undetectable		 3uawA-4ineA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ARG A 298
ASP A 299
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
None
SAH  A 501 (-4.0A)
 0.87A 3uj6A-4ineA:
38.6		 3uj6A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ILE A 253
ARG A 298
ASP A 299
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
None
None
 1.20A 3uj6A-4ineA:
38.6		 3uj6A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 182
TYR A 187
GLY A 232
ARG A 298
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.64A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 182
TYR A 187
GLY A 232
ILE A 253
ARG A 298
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
None
 1.16A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 182
TYR A 187
GLY A 232
ILE A 253
ASP A 299
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
None
None
 1.20A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		6 / 12 LEU A 182
TYR A 187
ILE A 204
GLY A 232
ASP A 299
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.74A 3uj7A-4ineA:
38.4		 3uj7A-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 182
GLY A 232
GLY A 234
ARG A 298
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.57A 3uj7B-4ineA:
38.6		 3uj7B-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		6 / 12 LEU A 182
ILE A 204
GLY A 232
GLY A 234
ASP A 299
HIS A 303
 SAH  A 501 (-4.0A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.79A 3uj7B-4ineA:
38.6		 3uj7B-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 5 TYR A 187
SER A 205
ASP A 254
ASP A 281
 SAH  A 501 ( 4.1A)
SAH  A 501 (-2.7A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 0.38A 3uj7B-4ineA:
38.6		 3uj7B-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 236
GLY A 238
ASP A 254
ASP A 281
 SAH  A 501 (-3.6A)
None
None
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 1.09A 4b17A-4ineA:
11.5		 4b17A-4ineA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 182
ASP A 230
GLY A 234
GLY A 237
LEU A 255
 SAH  A 501 (-4.0A)
SAH  A 501 ( 4.8A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.3A)
 0.82A 4blvA-4ineA:
10.3		 4blvA-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 7 TYR A 343
ARG A 347
GLY A 411
LYS A 415
 OPE  A 502 (-4.6A)
OPE  A 502 (-3.9A)
None
OPE  A 502 (-2.7A)
 0.52A 4fgzA-4ineA:
38.6		 4fgzA-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 TYR A 343
ARG A 347
GLY A 411
LYS A 415
 OPE  A 502 (-4.6A)
OPE  A 502 (-3.9A)
None
OPE  A 502 (-2.7A)
 0.56A 4fgzA-4ineA:
38.6
4fgzB-4ineA:
38.6		 4fgzA-4ineA:
23.63
4fgzB-4ineA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 230
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 ( 4.8A)
 1.07A 4fp9C-4ineA:
9.8		 4fp9C-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.58A 4fp9D-4ineA:
10.9		 4fp9D-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 236
GLY A 238
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 1.00A 4fp9D-4ineA:
10.9		 4fp9D-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 230
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 ( 4.8A)
 1.07A 4fp9F-4ineA:
10.9		 4fp9F-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 236
GLY A 237
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.46A 4fzvA-4ineA:
10.4		 4fzvA-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 236
GLY A 238
LEU A 255
SER A 256
ASP A 281
 None
None
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.92A 4fzvA-4ineA:
10.4		 4fzvA-4ineA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
LEU A 255
SER A 256
ALA A 282
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
 0.84A 4htfA-4ineA:
17.3		 4htfA-4ineA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
LEU A 255
SER A 256
ALA A 282
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
 0.76A 4htfB-4ineA:
16.7		 4htfB-4ineA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		6 / 12 TYR A 187
ILE A 204
GLY A 232
GLY A 234
ARG A 298
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.70A 4iv0A-4ineA:
38.0		 4iv0A-4ineA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 4 SER A 205
ASP A 254
MET A 259
ASP A 281
 SAH  A 501 (-2.7A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.5A)
 0.82A 4iv0A-4ineA:
38.0		 4iv0A-4ineA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 234
MET A 259
ILE A 231
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-4.0A)
 1.12A 4iv0B-4ineA:
36.7		 4iv0B-4ineA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 TYR A 187
ILE A 204
GLY A 232
GLY A 234
ASP A 281
ARG A 298
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.5A)
None
SAH  A 501 (-4.0A)
 0.64A 4iv0B-4ineA:
36.7		 4iv0B-4ineA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 TYR A 187
ILE A 204
GLY A 232
GLY A 234
MET A 259
ARG A 298
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-4.0A)
 0.87A 4iv0B-4ineA:
36.7		 4iv0B-4ineA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 GLY A 232
GLY A 234
ASP A 254
MET A 259
ASP A 281
ARG A 298
HIS A 303
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.5A)
None
SAH  A 501 (-4.0A)
 0.70A 4iv8A-4ineA:
33.3		 4iv8A-4ineA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		7 / 12 GLY A 232
GLY A 234
ASP A 254
MET A 259
ASP A 281
ARG A 298
HIS A 303
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.5A)
None
SAH  A 501 (-4.0A)
 0.73A 4iv8B-4ineA:
33.1		 4iv8B-4ineA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN0_A_MTXA301_1
(FOLATE RECEPTOR BETA)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
TYR A 195
GLN A 346
ARG A 347
SER A 407
 SAH  A 501 ( 4.1A)
OPE  A 502 (-3.9A)
None
OPE  A 502 (-3.9A)
None
 1.36A 4kn0A-4ineA:
0.0		 4kn0A-4ineA:
17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		12 / 12 PHE A 178
TYR A 187
GLY A 232
GLY A 234
LEU A 255
SER A 256
ASP A 281
ALA A 282
ARG A 298
CYH A 300
HIS A 303
ILE A 304
 None
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.5A)
 0.40A 4krhA-4ineA:
57.0		 4krhA-4ineA:
53.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		12 / 12 PHE A 178
TYR A 187
PHE A 203
GLY A 232
GLY A 234
LEU A 255
SER A 256
ALA A 282
ARG A 298
CYH A 300
HIS A 303
ILE A 304
 None
SAH  A 501 ( 4.1A)
None
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.5A)
 0.46A 4krhB-4ineA:
57.1		 4krhB-4ineA:
53.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 4 ILE A 204
SER A 205
ASP A 254
ASP A 281
 SAH  A 501 (-4.5A)
SAH  A 501 (-2.7A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 0.12A 4krhB-4ineA:
57.1		 4krhB-4ineA:
53.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		6 / 12 ILE A 204
GLY A 232
GLY A 234
MET A 259
ARG A 298
HIS A 303
 SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-4.0A)
 0.89A 4mwzA-4ineA:
36.3		 4mwzA-4ineA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		6 / 12 TYR A 187
ILE A 204
GLY A 232
GLY A 234
ARG A 298
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.69A 4mwzA-4ineA:
36.3		 4mwzA-4ineA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 SER A   3
ASP A 158
ASP A 109
 None
 0.85A 4mwzA-4ineA:
36.3		 4mwzA-4ineA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 SER A 205
ASP A 254
ASP A 281
 SAH  A 501 (-2.7A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 0.48A 4mwzA-4ineA:
36.3		 4mwzA-4ineA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		6 / 12 TYR A 187
ILE A 204
GLY A 232
GLY A 234
ARG A 298
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.0A)
 0.68A 4mwzB-4ineA:
38.1		 4mwzB-4ineA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 4 SER A 205
ASP A 254
MET A 259
ASP A 281
 SAH  A 501 (-2.7A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.5A)
 0.81A 4mwzB-4ineA:
38.1		 4mwzB-4ineA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 THR A  85
ASN A 135
PHE A 168
 None
 0.83A 4pd9A-4ineA:
undetectable		 4pd9A-4ineA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.76A 4qdjA-4ineA:
18.2		 4qdjA-4ineA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 TYR A 187
GLY A 232
GLY A 234
SER A 256
MET A 259
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
 0.62A 4qtuB-4ineA:
18.8		 4qtuB-4ineA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 6 TYR A  12
ASN A  15
GLU A 288
TYR A 141
 None
 1.20A 4twdG-4ineA:
undetectable
4twdH-4ineA:
undetectable		 4twdG-4ineA:
21.03
4twdH-4ineA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
GLY A 236
LEU A 255
ALA A 282
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.3A)
SAH  A 501 (-3.6A)
 0.81A 4uciA-4ineA:
6.8		 4uciA-4ineA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
GLY A 236
LEU A 255
ALA A 282
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.3A)
SAH  A 501 (-3.6A)
 0.80A 4uciB-4ineA:
6.9		 4uciB-4ineA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 234
GLY A 236
LEU A 255
ALA A 282
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
None
SAH  A 501 (-4.3A)
SAH  A 501 (-3.6A)
 0.84A 4uckA-4ineA:
6.8		 4uckA-4ineA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 4 ASP A 230
GLY A 234
ASP A 254
ASP A 281
 SAH  A 501 ( 4.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 0.57A 5e72A-4ineA:
14.3		 5e72A-4ineA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 255
SER A 256
MET A 259
ALA A 282
PHE A 296
 SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.6A)
None
 1.34A 5jglA-4ineA:
17.0		 5jglA-4ineA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 TYR A 349
TYR A 195
GLN A 186
 OPE  A 502 (-4.7A)
OPE  A 502 (-3.9A)
OPE  A 502 (-4.0A)
 0.88A 5jsdA-4ineA:
undetectable
5jsdB-4ineA:
undetectable		 5jsdA-4ineA:
22.22
5jsdB-4ineA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		3 / 3 TYR A 349
TYR A 195
GLN A 186
 OPE  A 502 (-4.7A)
OPE  A 502 (-3.9A)
OPE  A 502 (-4.0A)
 0.88A 5jsdB-4ineA:
undetectable
5jsdC-4ineA:
undetectable		 5jsdB-4ineA:
22.22
5jsdC-4ineA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 SER A 205
GLY A 232
GLY A 234
SER A 256
ASP A 281
 SAH  A 501 (-2.7A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.5A)
 0.95A 5kpcB-4ineA:
22.5		 5kpcB-4ineA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 GLY A 200
GLN A 391
TRP A 197
ASP A 210
 None
 1.01A 5vlmH-4ineA:
undetectable		 5vlmH-4ineA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.12A 5vunA-4ineA:
undetectable		 5vunA-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.19A 5vunB-4ineA:
undetectable		 5vunB-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.20A 5vuoB-4ineA:
undetectable		 5vuoB-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 HIS A 251
ASP A 281
THR A 280
LEU A 182
 None
SAH  A 501 (-3.5A)
None
SAH  A 501 (-4.0A)
 1.20A 5w97A-4ineA:
undetectable
5w97C-4ineA:
undetectable
5w97c-4ineA:
undetectable		 5w97A-4ineA:
21.00
5w97C-4ineA:
18.60
5w97c-4ineA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 6 HIS A  53
ASN A  49
VAL A  26
LEU A  68
 None
 1.44A 5xdhA-4ineA:
undetectable
5xdhC-4ineA:
undetectable		 5xdhA-4ineA:
10.67
5xdhC-4ineA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 5 HIS A  53
ASN A  49
VAL A  26
LEU A  68
 None
 1.50A 5xdhB-4ineA:
undetectable		 5xdhB-4ineA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 ASN A 258
LEU A 107
LEU A 264
ALA A 261
 None
 0.76A 5y7pE-4ineA:
undetectable		 5y7pE-4ineA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 ALA A 194
GLY A 191
THR A 188
LEU A 389
PHE A 396
 None
 1.12A 5ybbA-4ineA:
10.3		 5ybbA-4ineA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 238
ASP A 254
LEU A 255
ASP A 281
 SAH  A 501 (-3.6A)
None
SAH  A 501 (-2.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-3.5A)
 0.75A 5yniA-4ineA:
8.4		 5yniA-4ineA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 GLY A 232
GLY A 238
ASP A 254
LEU A 255
ASP A 281
 SAH  A 501 (-3.6A)
None
SAH  A 501 (-2.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-3.5A)
 0.79A 5ynmA-4ineA:
8.5		 5ynmA-4ineA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		4 / 8 SER A 257
ARG A 179
GLN A 115
ASN A 258
 None
 1.16A 6auuB-4ineA:
undetectable		 6auuB-4ineA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4ine PROTEIN PMT-2
(Caenorhabditis
elegans) 		5 / 12 ASP A 230
GLY A 232
GLY A 234
ASP A 281
PHE A 296
 SAH  A 501 ( 4.8A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.6A)
SAH  A 501 (-3.5A)
None
 0.68A 6nj9K-4ineA:
11.0		 6nj9K-4ineA:
20.40